Early-life metal exposure and schizophrenia: A proof-of-concept study using novel tooth-matrix biomarkers

European Psychiatry - Tập 36 - Trang 1-6 - 2016
A. Modabbernia1,2,3, Eva Velthorst4,2, Chris Gennings1, Lieuwe de Haan4, Christine Austin1, Arjen L. Sutterland4, Josephine Mollon5, Sophia Frangou2,6, Robert O. Wright1, Manish Arora1, Abraham Reichenberg1,2,7,3
1Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, United States
2Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, United States
3Seaver Center for Autism Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, United States
4Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
5Department of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, England United Kingdom
6Psychosis Research Program, Icahn School of Medicine at Mount Sinai, New York, United States
7Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, United States

Tóm tắt

AbstractBackgroundDespite evidence for the effects of metals on neurodevelopment, the long-term effects on mental health remain unclear due to methodological limitations. Our objective was to determine the feasibility of studying metal exposure during critical neurodevelopmental periods and to explore the association between early-life metal exposure and adult schizophrenia.MethodsWe analyzed childhood-shed teeth from nine individuals with schizophrenia and five healthy controls. We investigated the association between exposure to lead (Pb2+), manganese (Mn2+), cadmium (Cd2+), copper (Cu2+), magnesium (Mg2+), and zinc (Zn2+), and schizophrenia, psychotic experiences, and intelligence quotient (IQ). We reconstructed the dose and timing of early-life metal exposures using laser ablation inductively coupled plasma mass spectrometry.ResultsWe found higher early-life Pb2+exposure among patients with schizophrenia than controls. The differences in log Mn2+and log Cu2+changed relatively linearly over time to postnatal negative values. There was a positive correlation between early-life Pb2+levels and psychotic experiences in adulthood. Moreover, we found a negative correlation between Pb2+levels and adult IQ.ConclusionsIn our proof-of-concept study, using tooth-matrix biomarker that provides direct measurement of exposure in the fetus and newborn, we provide support for the role of metal exposure during critical neurodevelopmental periods in psychosis.

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European Psychiatry

Tập 36

1-6

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