EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 update

Annals of the Rheumatic Diseases - Tập 76 Số 6 - Trang 960-977 - 2017
László Czirják1,2, Robert Landewé3,4, Ferdinand C. Breedveld5, Maya H Buch6, Katerina Chatzidionysiou7, Maxime Dougados8, J. Nam9, Sofía Ramiro10, Laure Gossec11, Ronald van Vollenhoven3,4, Martin Aringer12, Maarten Boers13, Christopher D. Buckley14, Frank Buttgereit6, Vivian P. Bykerk15,16, Mario H. Cardiel17, Maurizio Cutolo18, Yvonne van Eijk‐Hustings19, Paul Emery10, Axel Finckh20, Cem Gabay20, Juan J. Gómez‐Reino21, Laure Gossec22, Karel Pavelká23, Piet L. C. M. van Riel24, T. Huizinga11, Meghna Jani25, Д. Е. Каратеев26, Marios Kouloumas27,28, Tore Kvien29, Zhanguo Li30, Xavier Puéchal31, Iain B. McInnes32, Eduardo Mysler33, Peter Nash34, Gyula Poór35, Christophe Richez36, Andrea Becciolini37, Kenneth G. Saag38, Tanja Stamm39, Tsutomu Takeuchi40, René Westhovens41,42, Maarten de Wit43, Désirée van der Heijde10
1Hietzing Hospital
2Medical University of Vienna
3Amsterdam Rheumatology & Immunology Center
4Zuyderland Medical Center
5University Medical Center Utrecht
6Charité—University Medicine Berlin, Free University and Humboldt University Berlin
7Karolinska Institute
8Rhumatologie B, Hopital Cochin
9Leeds Teaching Hospitals NHS Trust and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds
10LEIDEN UNIVERSITY (MEDICAL CENTER)
11University of Twente,
12Medizinische Klinik und Poliklinik III, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden
13VU university medical center;
14Institute of Inflammation and Ageing (IIA), University of Birmingham, Queen Elizabeth Hospital
15Hospital for Special Surgery, Weill Cornell Medical College
16Rebecca McDonald Center for Arthritis & Autoimmune Disease, Mount Sinai Hospital, University of Toronto
17Centro de Investigación Clínica de Morelia SC
18University of Genoa
19University Of Maastricht
20University Hospitals of Geneva
21Fundación Ramón Dominguez, Hospital Clinico Universitario
22Sorbonne Universités, Pitié Salpêtrière Hospital
23Institut de Biologie Moléculaire et Cellulaire, Immunopathologie, et Chimie Thérapeutique, Strasbourg University Hospital and University of Strasbourg, CNRS
24Erasmus MC University Medical Center Rotterdam
25Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, University of Manchester
26V.A. Nasonova Research Institute of Rheumatology
27Cyprus League against Rheumatism
28European League Against Rheumatism
29Diakonhjemmet Hospital
30Beijing University People’s Hospital
31Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Université Paris-Sud, INSERM U1184, Center for Immunology of viral Infections and Autoimmune Diseases (IMVA)
32Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow
33Organización Médica de Investigación
34University of Queensland
35National Institute of Rheumatology and Physiotherapy, Semmelweis University
36FHU ACRONIM, Pellegrin Hospital and UMR CNRS 5164, Bordeaux University
37UNIVERSITY OF COLOGNE
38University of Alabama at Birmingham
39Section for Outcomes Research, Center for Medical Statistics, Informatics, and Intelligent Systems, Medical University of Vienna
40Keio University School of Medicine, Keio University Hospital
41Skeletal Biology and Engineering Research Center, KU Leuven
42University Hospitals Leuven
43VU Medical Centre

Tóm tắt

Recent insights in rheumatoid arthritis (RA) necessitated updating the European League Against Rheumatism (EULAR) RA management recommendations. A large international Task Force based decisions on evidence from 3 systematic literature reviews, developing 4 overarching principles and 12 recommendations (vs 3 and 14, respectively, in 2013). The recommendations address conventional synthetic (cs) disease-modifying antirheumatic drugs (DMARDs) (methotrexate (MTX), leflunomide, sulfasalazine); glucocorticoids (GC); biological (b) DMARDs (tumour necrosis factor (TNF)-inhibitors (adalimumab, certolizumab pegol, etanercept, golimumab, infliximab), abatacept, rituximab, tocilizumab, clazakizumab, sarilumab and sirukumab and biosimilar (bs) DMARDs) and targeted synthetic (ts) DMARDs (Janus kinase (Jak) inhibitors tofacitinib, baricitinib). Monotherapy, combination therapy, treatment strategies (treat-to-target) and the targets of sustained clinical remission (as defined by the American College of Rheumatology-(ACR)-EULAR Boolean or index criteria) or low disease activity are discussed. Cost aspects were taken into consideration. As first strategy, the Task Force recommends MTX (rapid escalation to 25 mg/week) plus short-term GC, aiming at >50% improvement within 3 and target attainment within 6 months. If this fails stratification is recommended. Without unfavourable prognostic markers, switching to—or adding—another csDMARDs (plus short-term GC) is suggested. In the presence of unfavourable prognostic markers (autoantibodies, high disease activity, early erosions, failure of 2 csDMARDs), any bDMARD (current practice) or Jak-inhibitor should be added to the csDMARD. If this fails, any other bDMARD or tsDMARD is recommended. If a patient is in sustained remission, bDMARDs can be tapered. For each recommendation, levels of evidence and Task Force agreement are provided, both mostly very high. These recommendations intend informing rheumatologists, patients, national rheumatology societies, hospital officials, social security agencies and regulators about EULAR's most recent consensus on the management of RA, aimed at attaining best outcomes with current therapies.

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