ELABELA and an ELABELA Fragment Protect against AKI

Arai, 2016, Apoptosis inhibitor of macrophage protein enhances intraluminal debris clearance and ameliorates acute kidney injury in mice., Nat Med, 22, 183, 10.1038/nm.4012

Molitoris, 2014, Therapeutic translation in acute kidney injury: The epithelial/endothelial axis., J Clin Invest, 124, 2355, 10.1172/JCI72269

Susantitaphong, 2013, World incidence of AKI: A meta-analysis., Clin J Am Soc Nephrol, 8, 1482, 10.2215/CJN.00710113

Kaushal, 2014, Challenges and advances in the treatment of AKI., J Am Soc Nephrol, 25, 877, 10.1681/ASN.2013070780

Chen, 2015, Apelin protects against acute renal injury by inhibiting TGF-β1., Biochim Biophys Acta, 1852, 1278, 10.1016/j.bbadis.2015.02.013

Lameire, 2013, Acute kidney injury: An increasing global concern., Lancet, 382, 170, 10.1016/S0140-6736(13)60647-9

Rabb, 2016, Inflammation in AKI: Current understanding, key questions, and knowledge gaps., J Am Soc Nephrol, 27, 371, 10.1681/ASN.2015030261

Xu, 2014, IL-22 ameliorates renal ischemia-reperfusion injury by targeting proximal tubule epithelium., J Am Soc Nephrol, 25, 967, 10.1681/ASN.2013060611

Jackson, 2016, Renal 2′,3′-cyclic nucleotide 3′-phosphodiesterase is an important determinant of AKI severity after ischemia-reperfusion., J Am Soc Nephrol, 27, 2069, 10.1681/ASN.2015040397

Yoshida, 2012, Caspase-3-independent internucleosomal DNA fragmentation in ischemic acute kidney injury., Nephron Exp Nephrol, 120, e103, 10.1159/000337358

Schumer, 1992, Morphologic, biochemical, and molecular evidence of apoptosis during the reperfusion phase after brief periods of renal ischemia., Am J Pathol, 140, 831

Ciccia, 2010, The DNA damage response: Making it safe to play with knives., Mol Cell, 40, 179, 10.1016/j.molcel.2010.09.019

Harper, 2007, The DNA damage response: Ten years after., Mol Cell, 28, 739, 10.1016/j.molcel.2007.11.015

Jackson, 2009, The DNA-damage response in human biology and disease., Nature, 461, 1071, 10.1038/nature08467

Hurley, 2007, ATM and ATR: Components of an integrated circuit., Cell Cycle, 6, 414, 10.4161/cc.6.4.3886

Sharma, 2012, Histone H2AX phosphorylation: A marker for DNA damage., Methods Mol Biol, 920, 613, 10.1007/978-1-61779-998-3_40

Tanaka, 2009, Cytometric analysis of DNA damage: Phosphorylation of histone H2AX as a marker of DNA double-strand breaks (DSBs)., Methods Mol Biol, 523, 161, 10.1007/978-1-59745-190-1_11

Chng, 2013, ELABELA: A hormone essential for heart development signals via the apelin receptor., Dev Cell, 27, 672, 10.1016/j.devcel.2013.11.002

Pauli, 2014, Toddler: An embryonic signal that promotes cell movement via Apelin receptors., Science, 343, 1248636, 10.1126/science.1248636

Deng, 2015, Apela regulates fluid homeostasis by binding to the APJ receptor to activate Gi signaling., J Biol Chem, 290, 18261, 10.1074/jbc.M115.648238

Pastorino, 1998, The overexpression of Bax produces cell death upon induction of the mitochondrial permeability transition., J Biol Chem, 273, 7770, 10.1074/jbc.273.13.7770

Mello, 2017, Protective effects of the exopolysaccharide Lasiodiplodan against DNA damage and inflammation induced by doxorubicin in rats: Cytogenetic and gene expression assays., Toxicology, 376, 66, 10.1016/j.tox.2016.05.010

Wondergem, 1991, Effect of adriamycin combined with whole body hyperthermia on tumor and normal tissues., Cancer Res, 51, 3559

Cao, 2016, CD103+ dendritic cells elicit CD8+ T cell responses to accelerate kidney injury in adriamycin nephropathy., J Am Soc Nephrol, 27, 1344, 10.1681/ASN.2015030229

Murza, 2015, C-Terminal modifications of apelin-13 significantly change ligand binding, receptor signaling, and hypotensive action., J Med Chem, 58, 2431, 10.1021/jm501916k

Margathe, 2014, Structure-activity relationship studies toward the discovery of selective apelin receptor agonists., J Med Chem, 57, 2908, 10.1021/jm401789v

Wang, 2015, Elabela-apelin receptor signaling pathway is functional in mammalian systems., Sci Rep, 5, 8170, 10.1038/srep08170

Liu, 2012, Autophagy plays a critical role in kidney tubule maintenance, aging and ischemia-reperfusion injury., Autophagy, 8, 826, 10.4161/auto.19419

Kimura, 2011, Autophagy protects the proximal tubule from degeneration and acute ischemic injury., J Am Soc Nephrol, 22, 902, 10.1681/ASN.2010070705

Wang, 2017, Histone HIST1H1C/H1.2 regulates autophagy in the development of diabetic retinopathy., Autophagy, 2017, 1

Ho, 2015, ELABELA is an endogenous growth factor that sustains hESC self-renewal via the PI3K/AKT pathway., Cell Stem Cell, 17, 435, 10.1016/j.stem.2015.08.010

Li, 2015, An Apela RNA-containing negative feedback loop regulates p53-mediated apoptosis in embryonic stem cells., Cell Stem Cell, 16, 669, 10.1016/j.stem.2015.04.002

Tsuruya, 2003, Accumulation of 8-oxoguanine in the cellular DNA and the alteration of the OGG1 expression during ischemia-reperfusion injury in the rat kidney., DNA Repair (Amst), 2, 211, 10.1016/S1568-7864(02)00214-8

Pabla, 2011, hMSH2 recruits ATR to DNA damage sites for activation during DNA damage-induced apoptosis., J Biol Chem, 286, 10411, 10.1074/jbc.M110.210989

Pabla, 2008, ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis., J Biol Chem, 283, 6572, 10.1074/jbc.M707568200

Jiang, 2006, Regulation of PUMA-alpha by p53 in cisplatin-induced renal cell apoptosis., Oncogene, 25, 4056, 10.1038/sj.onc.1209440

Krüger, 2016, Lovastatin prevents cisplatin-induced activation of pro-apoptotic DNA damage response (DDR) of renal tubular epithelial cells., Toxicol Appl Pharmacol, 292, 103, 10.1016/j.taap.2015.12.023

Camano, 2010, Cilastatin attenuates cisplatin-induced proximal tubular cell damage., J Pharmacol Exp Ther, 334, 419, 10.1124/jpet.110.165779

Bonventre, 2004, Ischemic acute renal failure: An inflammatory disease?, Kidney Int, 66, 480, 10.1111/j.1523-1755.2004.761_2.x

Abuelo, 2007, Normotensive ischemic acute renal failure., N Engl J Med, 357, 797, 10.1056/NEJMra064398

Chen, 2013, Exendin-4 and sitagliptin protect kidney from ischemia-reperfusion injury through suppressing oxidative stress and inflammatory reaction., J Transl Med, 11, 270, 10.1186/1479-5876-11-270

Murza, 2016, Discovery and structure-activity relationship of a bioactive fragment of ELABELA that modulates vascular and cardiac functions., J Med Chem, 59, 2962, 10.1021/acs.jmedchem.5b01549

Zhang, 2011, Porcine islet amyloid polypeptide fragments are refractory to amyloid formation., FEBS Lett, 585, 71, 10.1016/j.febslet.2010.11.050

Chen, 2014, Apelin inhibits the development of diabetic nephropathy by regulating histone acetylation in Akita mouse., J Physiol, 592, 505, 10.1113/jphysiol.2013.266411

Sun, 2016, Restoration of Opa1-long isoform inhibits retinal injury-induced neurodegeneration., J Mol Med (Berl), 94, 335, 10.1007/s00109-015-1359-y

Li, 2012, Accumulation of endoplasmic reticulum stress and lipogenesis in the liver through generational effects of high fat diets., J Hepatol, 56, 900, 10.1016/j.jhep.2011.10.018

Cai, 2015, Overexpression of glyceraldehyde 3-phosphate dehydrogenase prevents neurovascular degeneration after retinal injury., FASEB J, 29, 2749, 10.1096/fj.14-265801

Chen, 2011, Apelin alleviates diabetes-associated endoplasmic reticulum stress in the pancreas of Akita mice., Peptides, 32, 1634, 10.1016/j.peptides.2011.06.025

Huang, 2015, Histone acetyltransferase PCAF regulates inflammatory molecules in the development of renal injury., Epigenetics, 10, 62, 10.4161/15592294.2014.990780

Ding, 2014, DNA hypomethylation of inflammation-associated genes in adipose tissue of female mice after multigenerational high fat diet feeding., Int J Obes, 38, 198, 10.1038/ijo.2013.98

Liu, 2014, MPHOSPH1: A potential therapeutic target for hepatocellular carcinoma., Cancer Res, 74, 6623, 10.1158/0008-5472.CAN-14-1279