EFFICACY OF PLATELET-RICH PLASMA INTRA-ARTICULAR INJECTION IN ADJUNCTION TO CONVENTIONAL THERAPY FOR ASEPTIC NECROSIS OF FEMORAL HEAD

Le Thuy Duong1, Nguyen Minh Nui2, Luu Thi Binh3
1Hai Phong Medical College
3Thai Nguyen Province Health Department

Tóm tắt

Objectives: To evaluate the results of autologous platelet-rich plasma (PRP) intra-articular injection combined with medical therapy in treating aseptic necrosis of the femoral head (ANFH) after 5 months. Subjects and methods: Non-control interventional study, comparing before and after treatment for 30 patients (47 sterile necrotic femoral heads) who received 2 injections of PRP one month apart. Evaluation of clinical symptoms and images of necrosis on magnetic resonance imaging of the hip joint after 5 months. Results: The mean Visual Analogue Scale (VAS) decreased from 7.03 ± 1.90 to 3.77 ± 2.64, and the rate of severe pain decreased from 63.3% to 23.3%. The average range of motion of the hip joint increased (flexion from 87.17 ± 13.69 to 101.50 ± 14.69; abduction from 21.50 ± 5.89 to 28.50 ± 7.09; external rotation from 28.33 ± 4.01 to 34.00 ± 5.15; internal rotation from 30.33 ± 4.90 to 34.17 ± 4.93 degrees) with p < 0.001. According to Merle D'Aubigné, the ability to walk score increased from 4.05 ± 0.83 to 4.95 ± 0.76 (p < 0.001). Magnetic resonance imaging showed the rate of bone marrow edema decreased from 66.7% to 40.0% (p < 0.05), four sterile necrotic femoral heads from stage III to stage IV. Conclusion: The results of autologous PRP intra-articular injection combined with medical therapy in treating ANFH have markedly improved analgesia and motor function.

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