Lymphoma nang nho tu ruot và lymphome nốt khác nhau về môi trường vi mô miễn dịch thay vì hồ sơ đột biến của chúng

Blood - Tập 132 - Trang 1695-1702 - 2018
Johannes C. Hellmuth1,2, Abner Louissaint3, Monika Szczepanowski4,5, Sarah Haebe1,6, Alessandro Pastore7, Stefan Alig1,6, Annette M. Staiger8,9, Sylvia Hartmann10, Robert Kridel11, Matthew D. Ducar12, Peter Koch13, Martin Dreyling1, Martin-Leo Hansmann10, German Ott8, Andreas Rosenwald14, Randy D. Gascoyne15, David M. Weinstock16, Wolfgang Hiddemann1,6,17, Wolfram Klapper4, Oliver Weigert1,6,17
1Department of Medicine III, University Hospital, Ludwig-Maximilians-University, Munich, Germany
2Division of Hematology & Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY
3Department of Pathology, Massachusetts General Hospital, Boston, MA
4Department of Pathology, Hematopathology Section and Lymph Node Registry, and, Kiel, Germany
5Department of Internal Medicine II–Hematology, Oncology, Hematology Laboratory, University of Kiel, Kiel, Germany
6Experimental Leukemia and Lymphoma Research, University Hospital, Ludwig-Maximilians-University, Munich, Germany
7Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, NY
8Department of Clinical Pathology, Robert-Bosch-Krankenhaus, Stuttgart, Germany
9Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart and University of Tuebingen, Stuttgart, Germany
10Dr. Senckenberg Institute of Pathology, University Hospital of Frankfurt, Frankfurt am Main, Germany
11Princess Margaret Cancer Centre, Toronto, ON, Canada
12Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, MA
13University Hospital Muenster, Department of Medicine A, Muenster, Germany
14Institute of Pathology, University of Wuerzburg and Comprehensive Cancer Center Mainfranken, Wuerzburg, Germany
15Centre for Lymphoid Cancer, British Columbia Cancer Agency, Vancouver, BC, Canada
16Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
17German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany

Tóm tắt

Điểm chính Cảnh quan đột biến của DTFL có liên quan mật thiết đến FL nốt nhưng lại có ít đột biến đa bội / hai alen ở KMT2D hơn. Môi trường vi mô miễn dịch của DTFL khác biệt so với FL nốt và được đặc trưng bởi một chữ ký gen viêm mãn tính.

Từ khóa


Tài liệu tham khảo

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