Drug plasma levels and platelet 5‐HT uptake inhibition during long‐term treatment with fluvoxamine or lithium in patients with affective disorders.

British Journal of Clinical Pharmacology - Tập 15 Số S3 - 1983
K. Wood1, Cynthia Swade1, Mohammed T. Abou‐Saleh1, P. Milln1, Alec Coppen1
1MRC Neuropsychiatry Research Laboratory, West Park Hospital, Epsom, KT19 8PB,

Tóm tắt

1 Plasma levels and platelet 5‐HT uptake characteristics were determined at baseline and at various times during a long‐term study comparing fluvoxamine and lithium prophylaxis. 2 In the fluvoxamine‐ treated patients after 12 and 24 weeks of treatment, Km was significantly increased and y, the mean overall uptake, significantly decreased compared to the patients' own baseline values and to lithium treatment. No significant change was noted for Vmax. 3 For fluvoxamine, significant negative relationships were established between the Vmax of platelet 5‐HT uptake and plasma levels. 4 The trial had to be discontinued prematurely for some patients due to apparent lack of efficacy, unwanted effects or a combination of both in the fluvoxamine‐ treated patients. Low plasma levels of fluvoxamine may have contributed to the apparent lack of prophylactic efficacy of the drug. 5 Reference is made to the activity of receptor systems in patients receiving lithium and the consequent changes occurring after the administration of a potent 5‐HT re‐uptake inhibitor.

Từ khóa


Tài liệu tham khảo

10.1111/j.1476-5381.1977.tb07528.x

10.1192/bjp.133.1.28

10.1192/bjp.133.3.206

10.1192/bjp.128.5.479

10.1016/S0140-6736(71)91331-6

10.1007/BF00429689

FELDMAN M.&DENBER H.C.B.(1980).Long‐term study of fluvoxamine: a rapidly acting antidepressant.Prog. Neuro‐Psychopharmac. suppl. 141–142.

HALLSTROM C.O.S., 1976, Platelet uptake of 5‐hydroxytryptamine and dopamine in depression, Postgrad, med. J., 52, 3

HURST H.E., 1981, Determination of clovoxamine concentration in human plasma by electron‐capture gas chromatography, Clin. Chem., 27, 1210, 10.1093/clinchem/27.7.1210

10.1017/S0033291700046304

10.1055/s-0028-1094487

10.1016/S0140-6736(82)92206-1

10.1001/archpsyc.1973.01750330035006

10.1007/BF01252962

Thông tin
Thông tin xuất bản

British Journal of Clinical Pharmacology

Tập 15 Số S3

Thông tin tác giả