Draft Genome Sequence of the Sexually Transmitted Pathogen Trichomonas vaginalis

American Association for the Advancement of Science (AAAS) - Tập 315 Số 5809 - Trang 207-212 - 2007
Jane M. Carlton1,2,3,4,5, Robert P. Hirt1,2,3,4,5, Joana C. Silva1,2,3,4,5, Arthur L. Delcher1,2,3,4,5, Michael C. Schatz1,2,3,4,5, Qi Zhao1,2,3,4,5, Jennifer R. Wortman1,2,3,4,5, Shelby Bidwell1,2,3,4,5, U. Cecilia M. Alsmark1,2,3,4,5, Sébastien Besteiro1,2,3,4,5, Thomas Sicheritz‐Pontén1,2,3,4,5, Christophe Noël1,2,3,4,5, Joel B. Dacks1,2,3,4,5, Peter G. Foster1,2,3,4,5, Cédric Simillion1,2,3,4,5, Yves Van de Peer1,2,3,4,5, Diego Miranda‐Saavedra1,2,3,4,5, Geoffrey J. Barton1,2,3,4,5, Gareth D. Westrop1,2,3,4,5, Sylke Müller1,2,3,4,5, Daniele Dessì1,2,3,4,5, Pier Luigi Fiori1,2,3,4,5, Qinghu Ren1,2,3,4,5, Ian T. Paulsen1,2,3,4,5, Hanbang Zhang1,2,3,4,5, Felix Bastida1,2,3,4,5, Augusto Simoes‐Barbosa1,2,3,4,5, Mark T. Brown1,2,3,4,5, Richard D. Hayes1,2,3,4,5, Mandira Mukherjee1,2,3,4,5, Cheryl Okumura1,2,3,4,5, Rachel Schneider1,2,3,4,5, Alias Smith1,2,3,4,5, Štěpánka Vaňáčová1,2,3,4,5, Maria Villalvazo1,2,3,4,5, Brian J. Haas1,2,3,4,5, Mihaela Pertea1,2,3,4,5, Tamara V. Feldblyum1,2,3,4,5, Terry Utterback1,2,3,4,5, Chung-Li Shu1,2,3,4,5, Kazutoyo Osoegawa1,2,3,4,5, Pieter J. de Jong1,2,3,4,5, Ivan Hrdý1,2,3,4,5, Lenka Horváthová1,2,3,4,5, Zuzana Zubáčová1,2,3,4,5, Pavel Doležal1,2,3,4,5, Shehre-Banoo Malik1,2,3,4,5, John M. Logsdon1,2,3,4,5, Katrin Henze1,2,3,4,5, Arti Gupta1,2,3,4,5, Ching C. Wang1,2,3,4,5, Rebecca Dunne1,2,3,4,5, Jacqueline Upcroft1,2,3,4,5, Peter Upcroft1,2,3,4,5, Owen White1,2,3,4,5, Steven L. Salzberg1,2,3,4,5, Petrus Tang1,2,3,4,5, Cheng‐Hsun Chiu1,2,3,4,5, Ying‐Shiung Lee1,2,3,4,5, T. Martin Embley1,2,3,4,5, Graham H. Coombs1,2,3,4,5, Jeremy C. Mottram1,2,3,4,5, Jan Tachezy1,2,3,4,5, Claire M. Fraser1,2,3,4,5, Patricia J. Johnson1,2,3,4,5
1Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD, 20742, USA
2Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA.; Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark.; Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK.; Institute for Genomic Research, 9712 Medical Research Drive, Rockville, MD 20850, USA.; Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK.
3Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Lyngby, Denmark
4Division of Biology, Devonshire Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK.
5Wellcome Centre for Molecular Parasitology and Division of Infection and Immunity, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, UK.

Tóm tắt

We describe the genome sequence of the protist Trichomonas vaginalis , a sexually transmitted human pathogen. Repeats and transposable elements comprise about two-thirds of the ∼160-megabase genome, reflecting a recent massive expansion of genetic material. This expansion, in conjunction with the shaping of metabolic pathways that likely transpired through lateral gene transfer from bacteria, and amplification of specific gene families implicated in pathogenesis and phagocytosis of host proteins may exemplify adaptations of the parasite during its transition to a urogenital environment. The genome sequence predicts previously unknown functions for the hydrogenosome, which support a common evolutionary origin of this unusual organelle with mitochondria.

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We are grateful to the Trichomonas research community and M. Gottlieb for support and guidance during the duration of this project. We thank M. Delgadillo-Correa J. Shetty S. van Aken and S. Smith for technical support; T. Creasy S. Angiuoli H. Koo J. Miller J. Orvis P. Amedeo and E. Lee for engineering support; W. Majoros and G. Pertea for data manipulation; and S. Sullivan and E. F. Merino for editing. Funding for this project was provided by the National Institute of Allergy and Infectious Diseases (grants UO1 AI50913-01 and NIH-N01-AI-30071). The Burroughs Wellcome Fund and the Ellison Medical Foundation provided funds for Trichomonas community meetings during the genome project. The Chang Gung T. vaginalis Systems Biology Project was supported by grants (SMRPD33002 and SMRPG33115) from Chang Gung Memorial Hospital and Taiwan Biotech Company Limited. This whole genome shotgun project has been deposited at DNA Data Bank of Japan/European Molecular Biology Laboratory/GenBank under the project accession AAHC00000000. The version described here is the first version AAHC01000000.

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American Association for the Advancement of Science (AAAS)

Tập 315 Số 5809

207-212

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