Doxycycline Attenuated Pulmonary Fibrosis Induced by Bleomycin in Mice

Antimicrobial Agents and Chemotherapy - Tập 50 Số 2 - Trang 739-743 - 2006
Masaki Fujita1, Qing Ye2, Hiroshi Ouchi2, Eiji Harada2, Ichiro Inoshima2, Kazuyoshi Kuwano2, Yoichi Nakanishi2
1Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Higashiku, Fukuoka 812, Japan.
2Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

Tóm tắt

ABSTRACTThe administration of doxycycline prior to bleomycin in mice attenuated pulmonary fibrosis. Bronchoalveolar neutrophil influx and gelatinase activity, but not caseinolytic activity, were attenuated by doxycycline. Established fibrosis was not affected by doxycycline. Thus, doxycycline might be useful for slowing down pulmonary fibrosis by biological activity other than antibacterial activity.

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Tài liệu tham khảo

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Thông tin xuất bản

Antimicrobial Agents and Chemotherapy

Tập 50 Số 2

739-743

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