Doxycycline Attenuated Pulmonary Fibrosis Induced by Bleomycin in Mice
Tóm tắt
The administration of doxycycline prior to bleomycin in mice attenuated pulmonary fibrosis. Bronchoalveolar neutrophil influx and gelatinase activity, but not caseinolytic activity, were attenuated by doxycycline. Established fibrosis was not affected by doxycycline. Thus, doxycycline might be useful for slowing down pulmonary fibrosis by biological activity other than antibacterial activity.
Từ khóa
Tài liệu tham khảo
Abe, S., H. Nakamura, S. Inoue, H. Takeda, H. Saito, S. Kato, N. Mukaida, K. Matsushima, and H. Tomoike. 2001. Interleukin-8 gene repression by clarithromycin is mediated by the activator protein-1 binding sites in human bronchial epithelial cells. Am. J. Respir. Cell Mol. Biol.22:51-60.
Clark, J. G., and C. Kuhn III. 1982. Bleomycin-induced pulmonary fibrosis in hamsters: effect of neutrophil depletion on lung collagen synthesis. Am. Rev. Respir. Dis.126:737-739.
Fukuda, Y., M. Ishizaki, S. Kudoh, M. Kitaichi, and N. Yamanaka. 1998. Localization of matrix metalloproteinases-1, -2, and -9 and tissue inhibitor of metalloproteinase-2 in interstitial lung diseases. Lab. Investig.78:687-698.
Jain, A., L. Sangal, E. Basal, G. P. Kaushal, and S. K. Agarwal. 2002. Anti-inflammatory effects of erythromycin and tetracycline on Propionibacterium acnes induced production of chemotactic factors and reactive oxygen species by human neutrophils. Dermatol. Online J.8:2. [Online.] http://dermatology.cdlib.org/DOJvol8num2/original/antibiotics2/jain.html .
Nettelbladt, O., K. Lundberg, A. Tengblad, and R. Hallgren. 1990. Accumulation of hyaluronan in bronchoalveolar lavage fluid is independent of iron-, complement- and granulocyte-depletion in bleomycin-induced alveolitis in the rat. Eur. Respir. J.3:765-771.
Owens, G. R., I. L. Paradis, S. Gryzan, T. A. Medsger, Jr., W. P. Follansbee, H. A. Klein, and J. H. Dauber. 1986. Role of inflammation in the lung disease of systemic sclerosis: comparison with idiopathic pulmonary fibrosis. J. Lab. Clin. Med.107:253-260.