Đường dẫn truyền tín hiệu của heteromer thụ thể Dopamine D1-D2 trong não: sự liên quan sinh lý mới nổi

Molecular Brain - Tập 4 Số 1 - 2011
Ahmed Hasbi1, Brian F. O’Dowd1, Susan R. George1
1Centre for Addiction and Mental Health, Toronto, ON, M5T 1R8, Canada

Tóm tắt

Tóm tắt Dopamine là một neurotransmitter catecholamine quan trọng, điều chỉnh nhiều chức năng sinh lý, và liên quan đến tâm lý bệnh lý của nhiều bệnh như tâm thần phân liệt và nghiện thuốc. Thụ thể Dopamine D1 và D2 là hai thụ thể dopaminergic phong phú nhất trong striatum, và mặc dù đã có báo cáo rõ ràng về sự phân chia giữa các con đường thể hiện hai thụ thể này trong một số vùng phụ của não, nhưng sự hiện diện của heteromer thụ thể D1-D2 trong một tập hợp neuron độc nhất, hình thành một thực thể chức năng chuyển giao tín hiệu mới đã được chỉ ra. Gần đây, những tiến bộ đáng kể đã được thực hiện trong việc làm rõ các con đường tín hiệu được kích hoạt bởi heteromer thụ thể D1-D2 và sự liên quan sinh lý tiềm năng của chúng.

Từ khóa

#Dopamine #thụ thể D1 #thụ thể D2 #heteromer #tín hiệu #sinh lý học #tâm thần phân liệt #nghiện thuốc

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