Do all roads lead to Rome? Routes to metastasis development

International Journal of Cancer - Tập 128 Số 11 - Trang 2511-2526 - 2011
Jonathan P. Sleeman1,2,3, Irina Nazarenko1, Wilko Thiele1,2
1Karlsruher Institut für Technologie (KIT), Institut für Toxikologie und Genetik, Postfach 3640, Karlsruhe D-76021, Germany
2Medical Faculty Mannheim, University of Heidelberg, Mannheim D-68167, Germany
3Tel.: +49-621-3839955,

Tóm tắt

AbstractMetastasis, the life‐threatening aspect of cancer, is a systemic disease process. Considerable progress has been made in recent years regarding how tumor cells circulating in the blood and lymphatic systems interact with and extravasate into secondary sites, and what determines whether these disseminated tumors cells survive, remain dormant or go on to form macrometastases. New insights into the routes that tumor cells take once leaving the primary tumor have emerged. Novel concepts regarding early seeding of metastases coupled to parallel progression, self‐seeding of primary tumors by circulating tumor cells and the induction of premetastatic niches in distant organs by primary tumors have come to the fore. The perceived role of the lymphatic system in determining patterns of metastasis formation in distant organs has been reassessed. Together these new insights have the potential to offer new therapeutic options. In particular, the regulation of tumor cell dormancy emerges as a key event in metastasis formation, and therapeutic control of dormancy holds the promise of rendering cancer a chronic rather than life‐threatening disease.

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Tài liệu tham khảo

10.1016/0011-3840(87)90002-5

10.1016/S0140-6736(96)91015-6

10.1016/j.ejca.2010.02.039

10.1007/978-3-642-57151-0_6

10.1038/nrc865

10.1038/nrm1835

10.1016/j.tcb.2005.01.003

10.1083/jcb.200605135

10.1038/nmeth.1269

10.1083/jcb.200909003

10.1146/annurev-bioeng-061008-124949

10.1016/j.cell.2009.11.025

10.1016/j.semcancer.2009.05.005

Liotta LA, 1974, Quantitative relationships of intravascular tumor cells, tumor vessels, and pulmonary metastases following tumor implantation, Cancer Res, 34, 997

Butler TP, 1975, Quantitation of cell shedding into efferent blood of mammary adenocarcinoma, Cancer Res, 35, 512

10.1016/S0002-9440(10)61667-7

10.1002/cyto.a.20073

10.1016/S1470-2045(07)70140-7

Fidler IJ, 1970, Metastasis: guantitative analysis of distribution and fate of tumor embolilabeled with 125 I‐5‐iodo‐2'‐deoxyuridine, J Natl Cancer Inst, 45, 773

Price JE, 1986, Evidence that the process of murine melanoma metastasis is sequential and selective and contains stochastic elements, Cancer Res, 46, 5172

10.1016/S0955-0674(00)00251-9

10.1016/S0002-9440(10)65628-3

Cameron MD, 2000, Temporal progression of metastasis in lung: cell survival, dormancy, and location dependence of metastatic inefficiency, Cancer Res, 60, 2541

Varghese HJ, 2002, Activated ras regulates the proliferation/apoptosis balance and early survival of developing micrometastases, Cancer Res, 62, 887

10.1038/nm.2072

10.1038/71429

10.1016/S1091-255X(03)00023-4

10.1023/A:1025449031136

Honn KV, 1994, Tumor cell‐derived 12(S)‐hydroxyeicosatetraenoic acid induces microvascular endothelial cell retraction, Cancer Res, 54, 565

10.1002/ijc.2910630120

10.1006/excr.1998.3935

10.2353/ajpath.2006.050566

10.1111/j.1749-6632.1981.tb29726.x

10.1182/blood-2004-02-0434

10.1172/JCI113411

10.1172/JCI200422123

10.1371/journal.pone.0006562

10.1016/j.cell.2010.03.015

10.1084/jem.193.6.727

Crissman JD, 1985, Arrest and extravasation of B16 amelanotic melanoma in murine lungs. A light and electron microscopic study, Lab Invest, 53, 470

10.1002/ijc.2910340417

10.1002/ijc.2910350116

10.1158/0008-5472.CAN-09-4442

10.1016/j.semcancer.2010.04.005

10.1073/pnas.061615598

10.1158/0008-5472.CAN-03-1054

10.1084/jem.183.2.581

10.1074/jbc.M607219200

10.1182/blood.V96.10.3302

10.1074/jbc.M805144200

Paget S, The distribution of secondary growths in cancer of the breast, Lancet, 1889, 571

Ewing J, 1928, Neoplastic disease, a treatise on tumors, 77

Goldman E, 1906, Relation of cancer cells to blood vessels and ducts, Lancet, 1, 23

10.1002/1097-0142(197707)40:1<46::AID-CNCR2820400110>3.0.CO;2-T

Hart IR, 1980, Role of organ selectivity in the determination of metastatic patterns of B16 melanoma, Cancer Res, 40, 2281

Goodison S, 2003, Prolonged dormancy and site‐specific growth potential of cancer cells spontaneously disseminated from nonmetastatic breast tumors as revealed by labeling with green fluorescent protein, Clin Cancer Res, 9, 3808

Castillos L, 2004, Dormant tumor cells retrieved from metastasis‐free organs retain tumorigenic and metastatic capability, Proc Am Assoc Cancer Res, 45, 181

10.1172/JCI42002

10.1038/nrc1370

10.1038/nm1095-1035

10.1007/BF00046359

10.1074/jbc.274.17.11593

10.1016/S1535-6108(04)00079-0

10.1038/35065016

10.1593/neo.09272

10.1038/nrc2622

10.1038/nrc2621

10.1038/nature04186

10.1016/j.ccr.2008.11.012

10.1007/s10585-008-9209-8

10.1038/ncb1507

10.1038/ncb1794

10.1016/S1535-6108(02)00153-8

10.1002/mrm.21029

10.1111/j.1755-148X.2009.00647.x

10.1038/nm0295-149

10.1111/j.1600-0463.2008.01033.x

10.1002/ijc.23825

10.1158/1078-0432.CCR-08-1754

Naumov GN, 2002, Persistence of solitary mammary carcinoma cells in a secondary site: a possible contributor to dormancy, Cancer Res, 62, 2162

10.1023/B:BREA.0000004377.12288.3c

10.1007/s10549-005-9095-6

10.1186/bcr1611

10.1007/s10549-006-9484-5

Israeli RS, 1994, Sensitive nested reverse transcription polymerase chain reaction detection of circulating prostatic tumor cells: comparison of prostate‐specific membrane antigen and prostate‐specific antigen‐based assays, Cancer Res, 54, 6306

10.1002/(SICI)1097-0215(19961211)68:6<739::AID-IJC8>3.0.CO;2-4

10.1002/(SICI)1097-0142(19970615)79:12<2402::AID-CNCR16>3.0.CO;2-V

Melchior SW, 1997, Early tumor cell dissemination in patients with clinically localized carcinoma of the prostate, Clin Cancer Res, 3, 249

Weitz J, 1998, Dissemination of tumor cells in patients undergoing surgery for colorectal cancer, Clin Cancer Res., 4, 343

10.1016/j.ccr.2007.12.003

10.1038/nrc2627

10.4161/cc.5.16.3097

10.1016/S0092-8674(00)81333-1

10.1158/0008-5472.CAN-10-1040

10.1002/cncr.21466

10.1158/1078-0432.CCR-04-1110

10.1158/0008-5472.CAN-05-2553

10.1002/ijc.24916

Fisher B, 1970, Significance of the interrelationship of the lymph and blood vascular systems in tumor cell dissemination, Prog Clin Cancer, 4, 84

10.1016/S0344-0338(85)80139-4

10.1093/jnci/93.21.1638

10.1084/jem.20041896

10.1182/blood-2006-05-021758

10.1038/sj.bjc.6603443

10.2353/ajpath.2007.060761

10.1038/sj.onc.1210973

10.2967/jnumed.108.059733

10.1245/s10434-008-9815-3

10.1245/s10434-006-9234-2

10.1056/NEJM198506203122504

10.1097/SLA.0b013e3181c0e92a

10.1097/SLA.0b013e31812e6a73

10.1038/sj.bjc.6603364

10.1200/JCO.2005.01.5784

10.1016/S0959-8049(99)00133-1

10.1007/BF02032889

Lacour J, 1987, Is it useful to remove internal mammary nodes in operable breast cancer?, Eur J Surg Oncol, 13, 309

10.1016/S0169-5002(01)00445-7

10.1016/S1010-7940(02)00004-0

10.1002/bjs.1800810223

10.1097/SLA.0b013e31815c4037

10.1016/S1470-2045(10)70070-X

10.1016/S1470-2045(06)70623-4

10.1016/j.gassur.2005.08.034

10.1097/00000658-199905000-00003

10.1097/00000658-199810000-00007

10.1007/s00423-006-0143-4

10.1007/BF02054407

10.1038/sj.bjc.6603323

10.1093/jnci/dji102

10.1002/1097-0142(19820601)49:11<2420::AID-CNCR2820491133>3.0.CO;2-2

10.1016/S0025-6196(12)62768-2

10.1097/00000658-199609000-00002

10.1016/S0140-6736(97)08260-3

10.1056/NEJMoa060992

10.1158/0008-5472.CAN-09-2356

10.1158/0008-5472.CAN-07-6849

10.1158/0008-5472.CAN-06-2407

10.1007/s10555-006-9036-9

10.1111/j.1600-0463.2008.01027.x

10.1093/jnci/djk053

10.1158/0008-5472.CAN-07-3175

10.1016/j.ejca.2010.02.027

Aguirre‐Ghiso JA, 2003, ERK(MAPK) activity as a determinant of tumor growth and dormancy; regulation by p38(SAPK), Cancer Res, 63, 1684

Elkin M, 2001, Tail vein assay of cancer metastasis. Current Protocols in Cell Biology

10.1146/annurev.med.58.062105.204854

10.1007/s10585-007-9122-6

10.1038/nature07567

10.1126/science.1142596

10.1038/nm0909-1010

Sugarbaker EV, 1979, Some characteristics of metastasis in man, Am J Pathol, 97, 623

10.1016/j.cell.2008.04.045

Taniguchi T, 1995, Serum concentrations of hepatocyte growth factor in breast cancer patients, Clin Cancer Res, 1, 1031

10.1038/sj.bjc.6605017

10.1002/bjs.6780

10.1186/1471-2407-10-203

10.1002/ijc.24702

10.1016/j.ceb.2004.06.003

10.1038/ncb1596

10.1016/S0140-6736(02)09552-1

10.1053/j.gastro.2005.03.045

10.1158/0008-5472.CAN-06-1819

10.1038/ncb1725

10.1186/1471-2164-10-556

10.1073/pnas.0804543106

10.1158/0008-5472.CAN-09-2470

10.1158/0008-5472.CAN-06-3456

10.1038/nm0598-594

10.1016/S0959-8049(99)00090-8

10.1007/978-1-4615-0081-0_17

10.1016/j.bcmd.2005.06.008

10.1073/pnas.0801075105

10.1073/pnas.77.1.399

10.1593/neo.09822

10.1634/stemcells.2007-0128

10.4049/jimmunol.178.11.6867

10.1002/ijc.24249

10.2353/ajpath.2010.090777

10.1002/ijc.20657

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International Journal of Cancer

Tập 128 Số 11

2511-2526

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