Diverse host–virus interactions following caprine arthritis-encephalitis virus infection in sheep and goats

Journal of General Virology - Tập 94 Số 3 - Trang 634-642 - 2013
Antoine Rachid1, Benoit Croisé1, Pierre Russo2, M. Vignoni2, Daniela Lacerenza3, Sergio Rosati3, Jacek Kuźmak4, Stephen Valas1
1Anses, Niort Laboratory, Ruminant Retrovirus Unit, F-79012 Niort, France.
2Anses, Sophia-Antipolis Laboratory, Ruminant Pathology Unit, 06902 Sophia-Antipolis, France.
3Department of Animal Production, Epidemiology and Ecology, University of Turin, Italy
4Department of Biochemistry, National Veterinary Research Institute, 24-100 Pulawy, Poland

Tóm tắt

Interspecies transmissions substantially contribute to the epidemiology of small ruminant lentiviruses (SRLVs), including caprine arthritis encephalitis virus (CAEV) and visna-maëdi virus. However, comprehensive studies of host–virus interactions during SRLV adaptation to the new host are lacking. In this study, virological and serological features were analysed over a 6 month period in five sheep and three goats experimentally infected with a CAEV strain. Provirus load at the early stage of infection was significantly higher in sheep than in goats. A broad antibody reactivity against the matrix and capsid proteins was detected in goats, whereas the response to these antigens was mostly type-specific in sheep. The humoral response to the major immunodominant domain of the surface unit glycoprotein was type-specific, regardless of the host species. These species-specific immune responses were then confirmed in naturally infected sheep and goats using sera from mixed flocks in which interspecies transmissions were reported. Taken together, these results provide evidence that SRLV infections evolve in a host-dependent manner, with distinct host–virus interactions in sheep and goats, and highlight the need to consider both SRLV genotypes in diagnosis, particularly in sheep.

Từ khóa


Tài liệu tham khảo

10.1016/j.tvjl.2007.01.025

Bertoni, 2000, B-cell epitopes of the envelope glycoprotein of caprine arthritis-encephalitis virus and antibody response in infected goats, J Gen Virol, 81, 2929, 10.1099/0022-1317-81-12-2929

10.1038/292240a0

Brodie, 1995, Ovine lentivirus expression and disease. Virus replication, but not entry, is restricted to macrophages of specific tissues, Am J Pathol, 146, 250

10.1016/j.vetmic.2009.01.032

10.1016/j.vaccine.2005.08.043

10.1016/S0166-0934(00)00155-5

10.1016/j.virusres.2006.03.002

10.1099/vir.0.2008/000851-0

10.1016/j.virusres.2006.12.014

10.1016/j.vetmic.2008.09.069

10.1016/j.vetmic.2009.03.002

10.1099/0022-1317-66-6-1233

Grego, 2002, Genetic heterogeneity of small ruminant lentiviruses involves immunodominant epitope of capsid antigen and affects sensitivity of single-strain-based immunoassay, Clin Diagn Lab Immunol, 9, 828

10.1016/j.vetmic.2004.12.007

10.1099/vir.0.83292-0

10.1128/CVI.00459-08

10.1128/CVI.00349-09

10.1128/JVI.75.16.7384-7391.2001

10.1016/0378-1135(89)90078-3

Kajikawa, 1990, Analysis of antibody responses to phenotypically distinct lentiviruses, J Clin Microbiol, 28, 764, 10.1128/JCM.28.4.764-770.1990

10.1006/viro.1996.0569

Knowles, 1990, Severity of arthritis is predicted by antibody response to gp135 in chronic infection with caprine arthritis-encephalitis virus, J Virol, 64, 2396, 10.1128/JVI.64.5.2396-2398.1990

10.1016/j.vetimm.2006.03.016

Lairmore, 1987, Replication and cytopathic effects of ovine lentivirus strains in alveolar macrophages correlate with in vivo pathogenicity, J Virol, 61, 4038, 10.1128/JVI.61.12.4038-4042.1987

Lifson, 1997, The extent of early viral replication is a critical determinant of the natural history of simian immunodeficiency virus infection, J Virol, 71, 9508, 10.1128/JVI.71.12.9508-9514.1997

10.1177/030098589403100610

10.1128/JCM.44.3.981-991.2006

Narayan, 1984, Lack of neutralizing antibodies to caprine arthritis-encephalitis lentivirus in persistently infected goats can be overcome by immunization with inactivated Mycobacterium tuberculosis, J Virol, 49, 349, 10.1128/JVI.49.2.349-355.1984

10.1016/j.virusres.2011.11.019

10.1128/JVI.02319-06

10.1073/pnas.94.1.254

10.1016/j.virol.2005.06.013

10.1016/j.virol.2010.08.004

Quérat, 1984, Highly lytic and persistent lentiviruses naturally present in sheep with progressive pneumonia are genetically distinct, J Virol, 52, 672, 10.1128/JVI.52.2.672-679.1984

10.1016/j.vetmic.2009.04.005

10.1016/j.vetmic.2009.12.020

10.1016/j.vetimm.2010.11.001

10.1016/S0168-1702(99)00031-3

10.1016/j.virol.2003.09.047

10.1128/JVI.78.14.7518-7522.2004

10.1128/JVI.80.2.912-919.2006

10.1016/0882-4010(91)90095-R

10.1007/BF01317137

10.1016/S0034-5288(03)00098-5

10.2741/2166

10.1097/00002030-199410000-00008

10.1016/0042-6822(87)90188-7

Zanoni, 1998, Phylogenetic analysis of small ruminant lentiviruses, J Gen Virol, 79, 1951, 10.1099/0022-1317-79-8-1951

Thông tin
Thông tin xuất bản

Journal of General Virology

Tập 94 Số 3

634-642

Thông tin tác giả