Diurnal Variations of the Serum Iron in Normal Subjects and in Patients with Haemochromatosis

British Journal of Haematology - Tập 17 Số 4 - Trang 351-358 - 1969
Rajalingam Sinniah1, J R Doggart1, D. W. Neill1
1Department of Pathology, The Queen's University of Belfast, and Biochemistry Department, Royal Victoria Hospital, Belfast, Northern Ireland

Tóm tắt

Summary. A definite diurnal variation in serum iron exists in normal subjects, in which the serum iron levels are highest in the morning or at noon, and then gradually fall throughout the day to reach their lowest values in the evening; the serum iron concentration rises again the following morning after sleep. The diurnal rhythm may be regulated by the activity of the reticulo‐hypothalamic system, which may be under the influence of neurogenic or hormonal factors. Contrary to other workers, there is a definite diurnal variation in the serum iron concentration in patients with idiopathic haemochromatosis.

Từ khóa


Tài liệu tham khảo

Babson A. L., 1967, A source of error in an autoanalyzer determination of serum iron, Clin. Chem., 13, 163, 10.1093/clinchem/13.2.163

Bowie E. J. W., 1963, Daily variation in the concentration of iron in serum, Amer. J. clin. Path., 40, 491, 10.1093/ajcp/40.5.491

Brain Lord, 1962, Diseases of the Nervous System, 817

Gruchy G. C., 1964, Clinical Haematology in Medical Practice, 77

Finch S. C., 1955, Idiopathic haemochromatosis, an iron storage disease, Medicine (Baltimore), 34, 381, 10.1097/00005792-195512000-00001

10.1097/00000441-195206000-00005

Halberg F. Halberg E. Barnum C. P.andBittner J. J.(1959). ‘Physiologic 24‐hr periodicity in human beings and mice the lighting regimen and daily routine.’Symposium on Photoperiodisnt in Plants and Animals Gatlinburg. (Tenn. Amer. Ass. Adv. Sci.).

10.1080/00325481.1958.11692235

10.3181/00379727-75-18102

Heindel W., 1955, Tagesrhythmische Serumeisen‐ und Eiweisschwankungen bei vegetativer Dystonie, Dtsch. Z. Verdau.- u. Stoffwechselkr., 15, 62

Hemmeler G., 1943, Le fer sérique dans les ictères parenchymateux et par rétention, Schweiz. med. Wschr., 73, 1056

10.1111/j.0954-6820.1944.tb05421.x

10.1172/JCI101068

Paterson J. C. S., 1952, Hypoferraemia in the human subject: the importance of diurnal hypoferraemia, Clin. Sci., 11, 417

10.1042/bj0530227

Ramsay W. N. M., 1958, Plasma iron, Advanc. clin. Chem., 1, 14

10.1136/jcp.21.5.603

Vahlquist B. C., 1941, Das serumeisen, Acta paediat., 28, 1

Wetzel. Quoted byHamiltonet al.(1950).

10.1136/jcp.18.1.98

Thông tin
Thông tin xuất bản

British Journal of Haematology

Tập 17 Số 4

351-358

Thông tin tác giả