Distribution and Biotransformation of Methyl Mercuric Chloride in Different Tissues of Mice

Wiley - Tập 49 Số 1 - Trang 28-37 - 1981
Mandeep R. Mehra1, BongKyoo Choi1
1From the Division of Neuropathology, Department of Pathology and Environmental Health Sciences Center, University of Rochester Medical Center, Rochester, New York 14642, U.S.A.

Tóm tắt

Abstract: The distribution of 203Hg radioactivity has been studied in various organs of adult male and female mice from one hour to 21 days after treating with 203Hg‐labeled methyl mercuric chloride (MMC). The amount of methyl mercury (MeHg) and inorganic mercury (Hg) has also been determined by injecting single doses of non‐radioactive MMC, and subsequently measuring total, organic and inorganic Hg content by atomic absorption technique. In addition, photoemulsion histochemical method (PEHM) was used to demonstrate localization of Hg grains in various cellular compartments of organs and tissues. The highest levels of radioactivity were attained at 7 hours post‐treatment in all organs except for brain and testis. The testis showed the highest radioactivity at one day and the brain at two days post‐treatment. MeHg persisted in brain over a longer period though the level was not as high. The content of MeHg and inorganic Hg was maximum in kidneys as compared to other organs. The brain and the reproductive organs contained the least amount of inorganic Hg. By PEHM, Hg grains were most prominently observed in the sinusoids, Kupfer cells, hepatic cells and bile duct epithelium of liver; in the lumen of blood vessels, convoluted and collecting tubules of kidneys; and in the gastrointestinal epithelium. The pattern of uptake and distribution of MeHg correlated well with the morphological demonstration of Hg grains in tissue sections.

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Tài liệu tham khảo

10.1126/science.181.4096.230

Berglund F., 1969, Chemical fallout, 258

10.1080/00039896.1963.10663447

10.1080/00039896.1963.10663449

10.1080/00039896.1975.10666717

10.1016/0041-008X(76)90023-5

10.1007/BF00691129

10.1097/00005072-197207000-00007

10.1016/0024-3205(78)90317-X

10.1097/00005072-197811000-00001

10.1016/0041-008X(77)90051-5

Gage J. C., 1964, Distribution and excretion of methyl and phenyl mercury salts, Brit. J. Industr. Med., 21, 197

10.1007/BF00686067

10.1016/0041-008X(77)90153-3

MacGregor J. T., 1974, Advances in experimental medicine and biology, 463

McGill Methyl Mercury Study, 1980, A study of the effects of exposure to methylmercury on the health of individuals living in certain areas of the Province of Quebec

Magos L., 1972, Atomic absorption determination of total, inorganic and organic mercury in blood, J. Ass. Off. Chem., 55, 966

Matsumoto H., 1969, Pathological studies on organic mercury poisoning – supplement to histochemical demonstration of mercury in the brain of Minamata disease, Adv. Neurol. Sci., 13, 270

10.1007/BF01685496

10.1007/BF01608165

Norseth T.:Studies on the biotransformation of methylmercury in the rat.Doctoral thesis University of Rochester Rochester New York 1969 p.27.

10.1111/j.1600-0773.1971.tb00597.x

10.1016/0006-2952(70)90104-8

10.1080/00039896.1970.10667325

10.1080/00039896.1971.10665903

Sakai K., 1974, Time‐dependent distribution of 203Hg methylmercuric chloride in tissues and cells of rats, Japan J. Exp. Med., 45, 63

10.1267/ahc.8.257

Shaw C. M., 1975, Variability of neuropathologic lesions in experimental methylmercurial encephalopathy in primates, Amer. J. Path., 80, 451

Swensson A., 1959, Distribution and excretion of mercury compounds after single injection, AMA Arch. Indust. Health, 20, 432

Takeuchi T., 1972, Environmental mercury contamination, 277

10.1111/j.1471-4159.1966.tb04281.x

10.1038/220173a0

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Wiley

Tập 49 Số 1

28-37

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