Distinct Effects of T-bet in T H 1 Lineage Commitment and IFN-γ Production in CD4 and CD8 T Cells

American Association for the Advancement of Science (AAAS) - Tập 295 Số 5553 - Trang 338-342 - 2002
Susanne J. Szabo1, Brandon M. Sullivan1, Claudia Stemmann1, Abhay R. Satoskar2, Barry P. Sleckman3, Laurie H. Glimcher1,4
1Department of Immunology and Infectious Diseases, Harvard School of Public Health and
2Department of Microbiology, Ohio State University, Columbus, OH 43210, USA
3Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA
4Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.

Tóm tắt

T-bet is a member of the T-box family of transcription factors that appears to regulate lineage commitment in CD4 T helper (T H ) lymphocytes in part by activating the hallmark T H 1 cytokine, interferon-γ (IFN-γ). IFN-γ is also produced by natural killer (NK) cells and most prominently by CD8 cytotoxic T cells, and is vital for the control of microbial pathogens. Although T-bet is expressed in all these cell types, it is required for control of IFN-γ production in CD4 and NK cells, but not in CD8 cells. This difference is also apparent in the function of these cell subsets. Thus, the regulation of a single cytokine, IFN-γ, is controlled by distinct transcriptional mechanisms within the T cell lineage.

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Tài liệu tham khảo

10.1146/annurev.immunol.15.1.563

10.1146/annurev.immunol.15.1.749

10.1126/science.8197455

10.1016/S0092-8674(00)81288-X

10.1126/science.8456301

10.1126/science.8456300

10.1016/S0092-8674(00)81289-1

10.1056/NEJM199612263352604

10.1056/NEJM199612263352602

10.1093/clinids/24.5.982

10.1126/science.1061154

10.1016/S0168-9525(97)01144-X

10.1016/S0959-437X(97)80073-1

10.1016/S0092-8674(00)80702-3

10.1016/S1074-7613(01)00103-0

10.1126/science.1059835

Supplementary Web material is available on Science Online at www.sciencemag.org/cgi/content/full/295/5553/338/DC1.

A. O'Garra

10.1016/S0962-8924(00)01856-0

10.1016/S0952-7915(00)00210-7

10.1038/ng0797-311

10.1038/ng0197-30

10.1016/S1074-7613(00)80604-4

10.1126/science.279.5359.2118

S. J. Szabo et al. unpublished observations.

10.1146/annurev.iy.13.040195.001055

10.1016/S1074-7613(00)00035-2

10.4049/jimmunol.165.7.3571

10.1126/science.1065544

10.1016/S1074-7613(01)00085-1

10.4049/jimmunol.164.11.5890

R. Coico Protocols in Immunology (Wiley New York 1994) pp. 3.11.13–3.11.20.

We thank A. Dighe A. Wurster N. Iwakoshi and J. Rengarajan for thoughtful review of the manuscript; C. McCall for manuscript preparation; and L. (Nacho) Terrazas for assistance with the Leishmania experiment. Supported by grants from the National Institutes of Health (B.P.S. and L.H.G) and a gift from The G. Harold and Leila Y. Mathers Charitable Foundation (L.H.G) and by an Ohio State University Seed Grant (A.R.S) a Leukemia Society Special Fellowship (S.J.S.) and the Cancer Research Institute Investigator Award (B.P.S.). S.J.S and B.P.S. are recipients of the Burroughs Wellcome Foundation Career Development Award.

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American Association for the Advancement of Science (AAAS)

Tập 295 Số 5553

338-342

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