Disparate Serum Thioridazine Concentrations: Liquid Chromatography versus Radioreceptor Assay

Wiley - Tập 50 Số 1 - Trang 25-29 - 1982
Markku Linnoila1, Jack E. Rosenblatt1, Dilip V. Jeste1, T. Skinner1, William Z. Potter1, Richard Jed Wyatt1
1From the Clinical Psychobiology Branch, NIMH, Bethesda, Maryland, Adult Psychiatry Branch, NIMH, St. Elizabeth's Hospital Washington, D. C., and the Department of Psychiatry, Duke University Medical Center, Durham, North Carolina, U.S.A.

Tóm tắt

Abstract: A radioceceptor and a liquid chromatographic assay quantitating serum thioridazine and its active metabolites yielded widely disparate results. The difference between the results of the two assays was relatively random. Contrary to earlier suggestions the radioreceptor assay may not be suitable for the measurement of all neuroleptics particularly when a common reference, such as chlorpromazine, is used.

Từ khóa


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