Các đột biến gây bệnh trong Parkin làm suy giảm khả năng ubiquitination ti thể, sự tích tụ và quá trình mitophagy phụ thuộc HDAC6
Tóm tắt
Từ khóa
Tài liệu tham khảo
Abou-Sleiman, 2006, Expanding insights of mitochondrial dysfunction in Parkinson's disease, Nat. Rev. Neurosci., 7, 207, 10.1038/nrn1868
Chung, 2001, Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease, Nat. Med., 7, 1144, 10.1038/nm1001-1144
Iwata, 2005, HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin, J. Biol. Chem., 280, 40282, 10.1074/jbc.M508786200
Johnston, 2002, Cytoplasmic dynein/dynactin mediates the assembly of aggresomes, Cell Motil. Cytoskeleton., 53, 26, 10.1002/cm.10057
Kawaguchi, 2003, The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress, Cell., 115, 727, 10.1016/S0092-8674(03)00939-5
Lee, 2004, Merlin, a tumor suppressor, interacts with transactivation-responsive RNA-binding protein and inhibits its oncogenic activity, J. Biol. Chem., 279, 30265, 10.1074/jbc.M312083200
Lee, 2010, HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy, EMBO J., 29, 969, 10.1038/emboj.2009.405
Lim, 2005, Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation, J. Neurosci., 25, 2002, 10.1523/JNEUROSCI.4474-04.2005
Lücking, 2000, Association between early-onset Parkinson's disease and mutations in the parkin gene, N. Engl. J. Med., 342, 1560, 10.1056/NEJM200005253422103
McNaught, 2002, Aggresome-related biogenesis of Lewy bodies, Eur. J. Neurosci., 16, 2136, 10.1046/j.1460-9568.2002.02301.x
Mizushima, 2008, Autophagy fights disease through cellular self-digestion, Nature., 451, 1069, 10.1038/nature06639
Narendra, 2008, Parkin is recruited selectively to impaired mitochondria and promotes their autophagy, J. Cell Biol., 183, 795, 10.1083/jcb.200809125
Olzmann, 2007, Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6, J. Cell Biol., 178, 1025, 10.1083/jcb.200611128
Pandey, 2007, HDAC6 at the intersection of autophagy, the ubiquitin-proteasome system and neurodegeneration, Autophagy., 3, 643, 10.4161/auto.5050
Pankiv, 2007, p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy, J. Biol. Chem., 282, 24131, 10.1074/jbc.M702824200
Schwer, 2002, The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase, J. Cell Biol., 158, 647, 10.1083/jcb.200205057
Shimura, 2000, Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase, Nat. Genet., 25, 302, 10.1038/77060
Sriram, 2005, Familial-associated mutations differentially disrupt the solubility, localization, binding and ubiquitination properties of parkin, Hum. Mol. Genet., 14, 2571, 10.1093/hmg/ddi292
Vives-Bauza, 2010, PINK1-dependent recruitment of Parkin to mitochondria in mitophagy, Proc. Natl. Acad. Sci. USA., 107, 378, 10.1073/pnas.0911187107
Wang, 2005, Alterations in the solubility and intracellular localization of parkin by several familial Parkinson's disease-linked point mutations, J. Neurochem., 93, 422, 10.1111/j.1471-4159.2005.03023.x