Direct regulation of TWIST by HIF-1α promotes metastasis
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Harris, A. L. Hypoxia — a key regulatory factor in tumour growth. Nature Rev. Cancer 2, 38–47 (2002).
Semenza, G. L. HIF-1 and tumor progression: pathophysiology and therapeutics. Trends Mol. Med. 8, S62–S67 (2002).
Thompson, E. W., Newgreen, D. F. & Tarin, D. Carcinoma invasion and metastasis: a role for epithelial–mesenchymal transition? Cancer Res. 65, 5991–5995 (2005).
Thiery, J. P. Epithelial-mesenchymal transitions in tumour progression. Nature Rev. Cancer 2, 442–454 (2002).
Thiery, J. P. & Sleeman, J. P. Complex networks orchestrate epithelial-mesenchymal transitions. Nature Rev. Mol. Cell Biol. 7, 131–142 (2006).
Batlle, E. et al. The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells. Nature Cell Biol. 2, 84–89 (2000).
Cano, A. et al. The transcription factor Snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nature Cell Biol. 2, 76–83 (2000).
Peinado, H., Olmedo, D. & Cano, A. Snail, ZEB, and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nature Rev. Cancer 7, 415–428 (2007).
Moody, S. E. et al. The transcriptional repressor Snail promotes mammary tumor recurrence. Cancer Cell 8, 197–209 (2005).
Imai, T. et al. Hypoxia attenuates the expression of E-cadherin via up-regulation of SNAIL in ovarian carcinoma cells. Am. J. Pathol. 161, 1437–1447 (2003).
Krishnamachary, B. et al. Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B. Cancer Res. 66, 2725–2731 (2006).
Evans, A. J. et al. VHL promotes E2 box-dependent E-cadherin transcription by HIF-mediated regulation of SIP1 and Snail. Mol. Cell. Biol. 27, 157–169 (2007).
Erler, J.T., et al. Lysyl oxidase is essential for hypoxia-induced metastasis. Nature 440, 1222–1226 (2006).
Castanon, I. & Baylies, M. K. Twist in fate: evolutionary comparison of Twist structure and function. Gene 287, 11–22 (2002).
Furlong, E. E., Andersen, E. C., Null, B., White, K. P. & Scott, M. P. Patterns of gene expression during Drosophila mesoderm development. Science 293, 1629–1633 (2001).
Yang, J., et al. Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell 117, 927–939 (2004).
Lee, T. K., et al. Twist overexpression correlates with hepatocellular carcinoma metastasis through induction of epithelial-mesenchymal transition. Clin. Cancer Res. 12, 5369–5376 (2006).
Ryan, H. E. Lo, J., & Johnson, R. S. HIF-1α is required for solid tumor formation and embryonic vascularization. EMBO J. 17, 3005–3115 (1998).
Iyer, N.V. et al. Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1α. Genes Dev. 12, 149–162 (1998).
Chen, Z. F. & Behringer, R. R. Twist is required in head mesenchyme for cranial neural tube morphogenesis. Genes Dev. 9, 686–699 (1995).
Krishnamachary, B., et al. Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1. Cancer Res. 63, 1138–43 (2003).
Huang, L. E., Gu, J., Schau, M. & Bunn, H. F. Regulation of hypoxia-inducible factor 1α is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway. Proc. Natl Acad. Sci. USA 95, 7987–7992 (1998).
Sawair, F. A., et al. Invasive front grading: reliability and usefulness in the management of oral squamous cell carcinoma. J. Oral Pathol. Med. 32, 1–9 (2003).
Hirota, K. & Semenza, G. L. Regulation of angiogenesis by hypoxia-inducible factor 1. Crit. Rev. Oncol. Hematol. 59, 15–26 (2006).
Alexander, N.R., et al. N-cadherin gene expression in prostate carcinoma is modulated by integrin-dependent nuclear translocation of Twist1. Cancer Res. 66, 3365–3369 (2006).
Koshiji, M., et al. HIF-1α induces cell cycle arrest by functionally counteracting Myc. EMBO J. 23, 1949–1956 (2004).
Janssen, H. L., Haustermans, K. M., Balm, A. J. & Begg, A. C. Hypoxia in head and neck cancer: how much, how important? Head Neck 27, 622–638 (2005).
Pugh, C. W., Gleadle, J. & Maxwell, P.H. Hypoxia and oxidative stress in breast cancer: hypoxia signalling pathways. Breast Cancer Res. 3, 313–317 (2001).
Yang, M.H., et al. Overexpression of NBS1 induces epithelial-mesenchymal transition and co-expression of NBS1 and Snail predicts metastasis of head and neck cancer. Oncogene 26, 1459–1467 (2007).
Koukourakis, M.I., et al. Endogenous markers of two separate hypoxia response pathways (hypoxia-inducible factor 2α and carbonic anhydrase 9) are associated with radiotherapy failure in head and neck cancer patients recruited in the CHART randomized trial. J. Clin. Oncol. 24, 727–735 (2006).
Hui, E. P., et al. Coexpression of hypoxia-inducible factors 1α and 2α, carbonic anhydrase IX and vascular endothelial growth factor in nasopharyngeal carcinoma and relationship to survival. Clin. Cancer Res. 8, 2595–2604 (2002).
Trastour, C., et al. HIF-1α and CA IX staining in invasive breast carcinomas: prognosis and treatment outcome. Int. J. Cancer 120, 1451–1458 (2007).
Corsi, A. K., Kostas, S. A., Fire, A. & Krause, M. Caenorhabditis elegans Twist plays an essential role in non-striated muscle development. Development 127, 2041–2051 (2000).
Provot, S. et al. Hif-1α regulates differentiation of limb bud mesenchyme and joint development. J. Cell Biol. 177, 451–464 (2007).
Wu, K. J., et al. Direct activation of TERT transcription by c-Myc. Nature Genet. 21, 220–224 (1999).
Chiang, Y. C., Teng, S. C., Su, Y. N., Hsieh, F. J. & Wu, K. J. c-Myc directly regulates the transcription of the NBS1 gene involved in DNA double-strand break repair. J. Biol. Chem. 278, 19286–19291 (2003).
Tickoo, S. K., et al. Immunohistochemical expression of hypoxia-inducible factor-1α and its downstream molecules in sarcomatoid renal cell carcinoma. J. Urol. 177, 1258–1263 (2007).