Diffusion‐weighted imaging of the human optic nerve: A New approach to evaluate optic neuritis in multiple sclerosis

Magnetic Resonance in Medicine - Tập 38 Số 3 - Trang 484-491 - 1997
Tae Iwasawa1, Hiroko Matoba2, Akiko Ogi2, Hiroaki Kurihara3, Kimihiko Saito3, Tetsuo Yoshida3, Sho Matsubara3, Atsushi Nozaki4
1Department of Radiology, Yokohama City University School of Medicine, Japan
2Department of Opthalmology, Yokohama City University, School of Medicine, Yokohama, Japan
3Department of Radiology, Yokohama City University School of Medicine, Yokohama, Japan
4GE Yokogawa Medical System, Yokohama, Japan

Tóm tắt

AbstractThe apparent diffusion coefficient (ADC) in the optic nerve was measured from diffusion‐weighted magnetic resonance imaging using an intravoxel incoherent motion (IVIM) sequence. The subjects were seven normal volunteers and eight patients with multiple sclerosis (MS) with a total of four optic nerves with acute neuritis and nine nerves with chronic neuritis. The mean ADC (4.18 ± 1.13 × 10−3 mm2/s, n = 9) in the optic nerves with chronic neuritis was significantly higher than that in normal volunteers (1.56 ± 0.675 × 10−3 mm2/s, n = 14) and that in the nerves with acute neuritis (0.94 ± 0.43 × 10−3 mm2/s n = 4) (P < 0.001). The ADC is useful in assessing MS foci in the optic nerves.

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Magnetic Resonance in Medicine

Tập 38 Số 3

484-491

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