Differentiation of phenotypic activity and its genetic analysis in native populations of the caucasus

This study introduces a novel approach to the dissection of polygenic variation. First, multidimensional analysis was used to define groups within the normal population. Next, these groups were compared on behavioral and physiological measures to establish underlying mechanisms. Finally, groups were compared on a range of polymorphic markers to determine the extent of single-gene effects. As this approach was conducted using three ethnic populations, the implications of between-, as well as within-, population variation can be assessed.