Different cognitive profiles between mild cognitive impairment due to cerebral small vessel disease and mild cognitive impairment of Alzheimer’s disease origin

Journal of the International Neuropsychological Society - Tập 15 Số 6 - Trang 898-905 - 2009
Aihong Zhou1, Jianping Jia1
1Department of Neurology, Xuan Wu Hospital, Capital Medical University, Neurodegenerative Laboratory of Ministry of Education of the People's Republic of China, Beijing, China.

Tóm tắt

Abstract

Controversy surrounds the differences of the cognitive profile between mild cognitive impairment resulting from cerebral small vessel disease (MCI-SVD) and mild cognitive impairment associated with prodromal Alzheimer’s disease (MCI-AD). The aim of this study was to explore and compare the cognitive features of MCI-SVD and MCI-AD. MCI-SVD patients (n = 56), MCI-AD patients (n = 30), and normal control subjects (n = 80) were comprehensively evaluated with neuropsychological tests covering five cognitive domains. The performance was compared between groups. Tests that discriminated between MCI-SVD and MCI-AD were identified. Multiple cognitive domains were impaired in MCI-SVD group, while memory and executive function were mainly impaired in MCI-AD group. Compared with MCI-SVD, MCI-AD patients performed relatively worse on memory tasks, but better on processing speed measures. The AVLT Long Delay Free Recall, Digit Symbol Test, and Stroop Test Part A (performance time) in combination categorized 91.1% of MCI-SVD patients and 86.7% of MCI-AD patients correctly. Current study suggested a nonspecific neuropsychological profile for MCI-SVD and a more specific cognitive pattern in MCI-AD. MCI-AD patients demonstrated greater memory impairment with relatively preserved mental processing speed compared with MCI-SVD patients. Tests tapping these two domains might be potentially useful for differentiating MCI-SVD and MCI-AD patients. (JINS, 2009, 15, 898–905.)

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Tài liệu tham khảo

10.1161/01.STR.0000179092.59909.42

10.1002/1099-1166(200006)15:6<548::AID-GPS242>3.0.CO;2-U

10.1093/brain/awl385

10.1001/archneur.61.10.1545

10.1176/appi.ajp.162.11.2078

10.1001/archneur.58.3.397

10.1111/j.1749-6632.2002.tb04809.x

10.1161/01.STR.0000024432.34557.10

10.1001/archpsyc.1994.03950010051007

10.1136/jnnp.72.2.217

10.1161/01.STR.0000024433.36590.1B

Graham, 2004, Distinctive cognitive profiles in Alzheimer’s disease and subcortical vascular dementia, Journal of Neurology, Neurosurgery, and Psychiatry, 75, 61

10.1016/j.acn.2003.09.008

10.1007/s00415-002-0861-7

10.1016/0022-3956(75)90026-6

10.1016/j.acn.2003.08.009

10.3109/00207459008985956

10.1016/S1098-3597(01)90047-X

Alzheimer’s Disease Cooperative Study Group. (1999). A randomized, double-blind, placebo-controlled trial to evaluate the safety and efficacy of vitamin E and donepezil HCL (Aricept) to delay clinical progression from mild cognitive impairment (MCI) to Alzheimer’s disease (AD). Protocol no. ADC-008.

Lezak, 1995, Neuropsychological Assessment

10.1161/01.STR.32.6.1318

10.1056/NEJMoa050151

10.1017/S1355617708080831

10.1001/archneur.56.3.303

10.1212/WNL.41.7.1006

10.1093/arclin/19.1.11

10.1001/archneur.64.3.416

Osterrieth, 1994, Le test de copie d’ une figure complex: Contribution a l’ etude de la perception et de la memoire, Archives de Psychologie, 30, 286

10.1016/j.braindev.2005.02.007

10.1016/S1474-4422(02)00190-4

10.1037/0894-4105.19.4.520

10.1136/jnnp.2004.055657

10.1001/archneur.62.7.1160

10.1111/j.1365-2796.2004.01380.x

10.1159/000091435

1986, The construction of “The Clinical Memory Test”, Acta Psychologica Sinica, 18, 100

1994, Diagnostic and Statistical Manual of Mental Disorders

10.1159/000091522

10.1093/ageing/31.6.451

10.1093/brain/awh553

Delis, 2000, The Delis-Kaplan executive function scale

10.1111/j.1532-5415.2005.00632.x

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Thông tin xuất bản

Journal of the International Neuropsychological Society

Tập 15 Số 6

898-905

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