Difference of concentration of placental soluble fms-like tyrosine kinase-1(sFlt-1), placental growth factor (PlGF), and sFlt-1/PlGF ratio in severe preeclampsia and normal pregnancy
Tóm tắt
Placental soluble fms-like tyrosine kinase-1 (sFlt-1) which is an antagonist of vascular endothelial growth factor and placental growth factor (PIGF), is considered as one of etiology factors cause endothelial damage in preeclampsia due to increase of sFlt-1 level that change vascular endothelial integrity. This study aims to analyze the difference of sFlt-1 and PlGF concentration in severe preeclampsia and normal pregnancy, and the correlation between both in occurrence of severe preeclampsia. This is case control study involving 18 subjects with severe preeclampsia and 19 subjects with normal pregnancy as controls who met inclusion and exclusion criteria. Concentration of sFlt-1 and PlGF are measured with ELISA. Statistical analysis is performed with Chi square test, Fisher’s exact test, T test, Mann–Whitney test, and Spearman’s rank correlation test. This study results in no significant difference in characteristics of gestational age, and parity in both study groups. Median concentration of sFlt-1 in severe preeclampsia is higher (20,524.75 pg/mL) compared with normal pregnancy (6820.4 pg/mL). Concentration of PlGF is lower in severe preeclampsia (47 pg/mL) compared with normal pregnancy (337 pg/mL). sFlt-1 concentration is higher in severe preeclampsia compared to normal pregnancy. PlGF concentration is lower in severe preeclampsia compared to normal pregnancy. Ratio of sFlt-1 and PlGF concentration is significantly correlated in both severe preeclampsia and normal pregnancy. There is a significant negative correlation between the concentration of sFLt-1 and PlGF in normal pregnancy.
Tài liệu tham khảo
Cunningham FG, Norman FG, Kenneth JL, Larry CG, John CH, Katharine DW. Williams obstetrics. 22nd ed. New York: Williams and Wilkins; 2005.
Lindheimer, Marshall D, Sandra J, Taler, Gary Cunningham F. Hypertension in Pregnancy. J Am Soc Hypertens. 2008;2((6)):484–94.
Cunningham FG, Leveno KJ, Bloom SL, Hauth JC, Rause DJ, Spancy CY. Wiliams obstetrics. 23rd ed. New York: Mc Graw Hill; 2010.
Effendi JS, Permadi W, Hidayat D, Tjahyadi D, Mulyakusumah A, Hermawan M, et al. Annual Report 2010. Bandung: Department of Obstetric and Gynecology Faculty of Medicine, Padjadjaran University/Perjan Dr.Hasan Sadikin Hospital 2011.
Department of Obstetric and Gynecology Faculty of Medicine, Padjadjaran University/Perjan Dr.Hasan Sadikin Hospital. Annual Report 2003. Bandung: Department Obstetric and Gynecology Faculty of Medicine, Padjadjaran University, Perjan Dr.Hasan Sadikin Hospital Bandung; 2004.
Department of Obstetric and Gynecology Faculty of Medicine, Padjadjaran University Dr.Hasan Sadikin Hospital Annual Report 2004. Bandung: Departement of Obstetric and Gynecology Faculty of Medicine, Padjadjaran University/Perjan Dr.Hasan Sadikin Hospital; 2005.
Department of Obstetric and Gynecology Faculty of Medicine, Padjadjaran University Dr.Hasan Sadikin Hospital. Annual Report 2005. Bandung: Department of Obstetric and Gynecology Faculty of Medicine, Padjadjaran University/Perjan Dr.Hasan Sadikin Hospital; 2006.
Department of Obstetric and Gynecology Faculty of Medicine, Padjadjaran University Dr.Hasan Sadikin Hospital. Annual Report 2006. Bandung: Department of Obstetric and Gynecology Faculty of Medicine, Padjadjaran University/Perjan Dr.Hasan Sadikin Hospital; 2007.
Indonesia Survey of Demography and Health (SKDI). Number of Ibu Maternal Mortality. In: Ri D, editor. Jakarta; 2007. p. 1–6.
Roeshadi RH. Hypertension in Pregnancy. In: Hariadi R, editors Fetomaternal Medical Science. 1 edn. Surabaya: Fetomaternal Medical Community, Indonesia Obstetric and Gynecology Association; 2004. p. 494–99.
Robert J. Pregnancy-related hypertension. In: Creasy R, Iams J, editors. Maternal fetal medicine principle and practice. Philadelphia: WB Saunders; 2004. p. 859–80.
Park M, Brewster UC. Management of preeclampsia. Hosp Phys. 2007;43(11):25.
Yuan HT, Haig D, Krumanchi SA. Angiogenic factors in the pathogenesis of preeclampsia. Curr Top Dev Biol. 2005;71:297–312.
Ahmad S, Ahmed A. Elevated placental soluble vascular endothelial growth factor receptor-1 inhibits angiogenesis in preeclampsia. Circ Res. 2004;95(9):884–91.
Stepan H, Faber R, Dornhofer N, Huppertz B, Robitzki A, Walther T. New insight onto biology of preeclampsia. Biol Reprod. 2006;74(5):772–6.
Aggarwal PK, Chandel N, Jain V, Jha V. The relationship between circulating endothelin-1, soluble fms-like tyrosine kinase-1 and soluble endoglin in preeclampsia. J hum Hypertens. 2012;26(4):236–41.
Lam C, Lim KH, Karumanchi SA. Circulating angiogenic factors in the pathogenesis and prediction of preeclampsia. Hypertension. 2005;46:1077–85.
Stepan H, Geide A, Faber R. Soluble fms-like tyrosine kinase 1. New Eng J Med. 2004;351(21):2241–2.
Levine RJ, Qian C, Maynard SE, Yu KF, Epstein FH, Karumanchi SA. Serum sFlt1 concentration during preeclampsia and mid trimester blood pressure in healthy nulliparous women. Am J Obstet Gynecol. 2006;194:1034–41.
Purwosunu Y, Sekizawa A, Farina A, Wibowo N, Koide K, Okazaki S, et al. Evaluation of physiological alterations of placenta through analysis of cell free messenger ribonucleic acid concentrations of angiogenic factor. Am J Obstet Gynecol. 2008;198(1):124el–124e7.
Thana NG, Romerob R, Hillermannd R, Cozzie V, Nief G, Huppertzg B. Prediction of Preeclampsia—A Workshop Report. Placenta. 2008;29(Suppl A):83–5.
Mutter WP, Karumanchi SA. Molecular mechanisms of preeclampsia. Microvasc Res. 2008;75(1):1–8.
Grill S, Rusterholz C, Zanetti-Dällenbach R, Tercanli S, Holzgreve W, Hahn S, et al. Potential markers of preeclampsia—a review. Reprod Biol Endocrinol. 2009;7(70):10–1186.
Dechend R, Luft FC. Angiogenesis factors and preeclampsia. Nat Med. 2008;14(11):1187–8.
Tsatsaris V, Goffin F, Munaut C, Brichant J, Pignon M, Noel A, et al. Overexpression of the soluble vascular endothelial growth factor receptor in preeclamptic patients: pathophysiological consequences. J Clin Endocrinol Metab. 2008;88:5555–63.
Chen Yu. Novel angiogenic factors for predicting preeclampsia: sFlt-1, PlGF, and soluble endoglin. Open Clin Chem J. 2009;2:1–6.
Yang Gu, Lewis David F, Wang Yuping. Placental productions and expressions of soluble endoglin, soluble fms-like tyrosine kinase receptor-1, and placental growth factor in normal and preeclamptic pregnancies. J Clin Endocrinol Metab. 2008;93:260–6.
Kopcow Hernan D, Karumanchi Ananth. Angiogenic factors and natural killer (NK) cells in the pathogenesis of preeclampsia. J Reprod Immunol. 2007;76(1–2):23–9.
Levine Richard J, Lam Chun, Cong Qian MS, Yu Kai F, Maynard Sharon E, Sachs Benjamin P, et al. Soluble endoglin and other circulating antiangiogenic factors in preeclampsia. N Engl J Med. 2006;355:992–1005.
Creasy RK, Resnick R, Iams J. Maternal-fetal medicine: principles and practice. 6th ed. Philadelphia: WB Saunders Co.; 2009. p. 419–31.