Dietary Factors Promoting Brown and Beige Fat Development and Thermogenesis

Seale, 2008, PRDM16 controls a brown fat/skeletal muscle switch, Nature, 454, 961, 10.1038/nature07182

Seale, 2007, Transcriptional control of brown fat determination by PRDM16, Cell Metab, 6, 38, 10.1016/j.cmet.2007.06.001

van der Lans, 2013, Cold acclimation recruits human brown fat and increases nonshivering thermogenesis, J Clin Invest, 123, 3395, 10.1172/JCI68993

Rosenwald, 2013, Bi-directional interconversion of brite and white adipocytes, Nat Cell Biol, 15, 659, 10.1038/ncb2740

Rosenwald, 2014, The origin and definition of brite versus white and classical brown adipocytes, Adipocyte, 3, 4, 10.4161/adip.26232

Jeremic, 2017, Browning of white fat: novel insight into factors, mechanisms, and therapeutics, J Cell Physiol, 232, 61, 10.1002/jcp.25450

Mulya, 2016, Brown and beige adipose tissue: therapy for obesity and its comorbidities?, Endocrinol Metab Clin North Am, 45, 605, 10.1016/j.ecl.2016.04.010

Schrauwen, 2016, Combatting type 2 diabetes by turning up the heat, Diabetologia, 59, 2269, 10.1007/s00125-016-4068-3

Santulli, 2016, Adrenergic signaling in heart failure and cardiovascular aging, Maturitas, 93, 65, 10.1016/j.maturitas.2016.03.022

García-Ruiz, 2015, The intake of high-fat diets induces the acquisition of brown adipocyte gene expression features in white adipose tissue, Int J Obes, 39, 1619, 10.1038/ijo.2015.112

Petrovic, 2010, J Biol Chem, 285, 7153, 10.1074/jbc.M109.053942

Pesta, 2014, A high-protein diet for reducing body fat: mechanisms and possible caveats, Nutr Metab (Lond), 11, 53, 10.1186/1743-7075-11-53

Stohs, 2016, A review of natural stimulant and non-stimulant thermogenic agents, Phytother Res, 30, 732, 10.1002/ptr.5583

Yoneshiro, 2013, Recruited brown adipose tissue as an antiobesity agent in humans, J Clin Invest, 123, 3404, 10.1172/JCI67803

Ludy, 2012, The effects of capsaicin and capsiate on energy balance: critical review and meta-analyses of studies in humans, Chem Senses, 37, 103, 10.1093/chemse/bjr100

Yoneshiro, 2012, Nonpungent capsaicin analogs (capsinoids) increase energy expenditure through the activation of brown adipose tissue in humans, Am J Clin Nutr, 95, 845, 10.3945/ajcn.111.018606

Vosselman, 2013, Energy dissipation in brown adipose tissue: from mice to men, Mol Cell Endocrinol, 379, 43, 10.1016/j.mce.2013.04.017

Ohyama, 2016, A synergistic anti-obesity effect by a combination of capsinoids and cold temperature through promoting beige adipocyte biogenesis, Diabetes, 65, 1410, 10.2337/db15-0662

Kawada, 1986, Capsaicin-induced beta-adrenergic action on energy metabolism in rats: influence of capsaicin on oxygen consumption, the respiratory quotient, and substrate utilization, Proc Soc Exp Biol Med, 183, 250, 10.3181/00379727-183-42414

Watanabe, 1988, Adrenal sympathetic efferent nerve and catecholamine secretion excitation caused by capsaicin in rats, Am J Physiol, 255, E23

Ono, 1985, Intragastric administration of capsiate, a transient receptor potential channel agonist, triggers thermogenic sympathetic responses, J Appl Physiol, 2011, 789

Kawabata, 2009, Non-pungent capsaicin analogs (capsinoids) increase metabolic rate and enhance thermogenesis via gastrointestinal TRPV1 in mice, Biosci Biotechnol Biochem, 73, 2690, 10.1271/bbb.90555

Baskaran, 2016, Capsaicin induces browning of white adipose tissue and counters obesity by activating TRPV1 channel-dependent mechanisms, Br J Pharmacol, 173, 2369, 10.1111/bph.13514

Iwami, 2011, Extract of grains of paradise and its active principle 6-paradol trigger thermogenesis of brown adipose tissue in rats, Auton Neurosci, 161, 63, 10.1016/j.autneu.2010.11.012

Wang, 2015, Resveratrol induces brown-like adipocyte formation in white fat through activation of AMP-activated protein kinase (AMPK) alpha1, Int J Obes, 39, 967, 10.1038/ijo.2015.23

Um, 2010, AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol, Diabetes, 59, 554, 10.2337/db09-0482

Andrade, 2014, Resveratrol increases brown adipose tissue thermogenesis markers by increasing SIRT1 and energy expenditure and decreasing fat accumulation in adipose tissue of mice fed a standard diet, Eur J Nutr, 53, 1503, 10.1007/s00394-014-0655-6

Lagouge, 2006, Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha, Cell, 127, 1109, 10.1016/j.cell.2006.11.013

Rayalam, 2008, Resveratrol induces apoptosis and inhibits adipogenesis in 3T3–L1 adipocytes, Phytother Res, 22, 1367, 10.1002/ptr.2503

Kim, 2011, Resveratrol exerts anti-obesity effects via mechanisms involving down-regulation of adipogenic and inflammatory processes in mice, Biochem Pharmacol, 81, 1343, 10.1016/j.bcp.2011.03.012

Alberdi, 2013, Thermogenesis is involved in the body-fat lowering effects of resveratrol in rats, Food Chem, 141, 1530, 10.1016/j.foodchem.2013.03.085

Qiang, 2012, Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Ppargamma, Cell, 150, 620, 10.1016/j.cell.2012.06.027

Park, 2012, Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases, Cell, 148, 421, 10.1016/j.cell.2012.01.017

Baur, 2006, Resveratrol improves health and survival of mice on a high-calorie diet, Nature, 444, 337, 10.1038/nature05354

Cantó, 2009, AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity, Nature, 458, 1056, 10.1038/nature07813

Manach, 2005, Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies, Am J Clin Nutr, 81, 230S, 10.1093/ajcn/81.1.230S

Di Pierro, 2015, Potential role of bioavailable curcumin in weight loss and omental adipose tissue decrease: preliminary data of a randomized, controlled trial in overweight people with metabolic syndrome. Preliminary study, Eur Rev Med Pharmacol Sci, 19, 4195

Lone, 2016, Curcumin induces brown fat-like phenotype in 3T3–L1 and primary white adipocytes, J Nutr Biochem, 27, 193, 10.1016/j.jnutbio.2015.09.006

Kim, 2016, Proteomic identification of fat-browning markers in cultured white adipocytes treated with curcumin, Mol Cell Biochem, 415, 51, 10.1007/s11010-016-2676-3

Wang, 2015, Curcumin promotes browning of white adipose tissue in a norepinephrine-dependent way, Biochem Biophys Res Commun, 466, 247, 10.1016/j.bbrc.2015.09.018

Hursel, 2011, The effects of catechin rich teas and caffeine on energy expenditure and fat oxidation: a meta-analysis, Obes Rev, 12, e573, 10.1111/j.1467-789X.2011.00862.x

Nomura, 2008, Tea catechins enhance the mRNA expression of uncoupling protein 1 in rat brown adipose tissue, J Nutr Biochem, 19, 840, 10.1016/j.jnutbio.2007.11.005

Saito, 2015, Capsaicin and related food ingredients reducing body fat through the activation of TRP and brown fat thermogenesis, Adv Food Nutr Res, 76, 1, 10.1016/bs.afnr.2015.07.002

Lee, 2009, (-)-Epigallocatechin-3-gallate enhances uncoupling protein 2 gene expression in 3T3–L1 adipocytes, Biosci Biotechnol Biochem, 73, 434, 10.1271/bbb.80563

Yan, 2013, Green tea catechins prevent obesity through modulation of peroxisome proliferator-activated receptors, Sci China Life Sci, 56, 804, 10.1007/s11427-013-4512-2

Thielecke, 2010, Epigallocatechin-3-gallate and postprandial fat oxidation in overweight/obese male volunteers: a pilot study, Eur J Clin Nutr, 64, 704, 10.1038/ejcn.2010.47

Nagao, 2007, A green tea extract high in catechins reduces body fat and cardiovascular risks in humans, Obesity (Silver Spring), 15, 1473, 10.1038/oby.2007.176

Gosselin, 2013, Effects of green tea extracts on non-shivering thermogenesis during mild cold exposure in young men, Br J Nutr, 110, 282, 10.1017/S0007114512005089

Dulloo, 1999, Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans, Am J Clin Nutr, 70, 1040, 10.1093/ajcn/70.6.1040

Diepvens, 2007, Obesity and thermogenesis related to the consumption of caffeine, ephedrine, capsaicin, and green tea, Am J Physiol Regul Integr Comp Physiol, 292, R77, 10.1152/ajpregu.00832.2005

Hu, 2014, Metformin and berberine prevent olanzapine-induced weight gain in rats, PLoS One, 9, e93310, 10.1371/journal.pone.0093310

Zhang, 2014, Berberine activates thermogenesis in white and brown adipose tissue, Nat Commun, 5, 5493, 10.1038/ncomms6493

van Dam, 2015, Regulation of brown fat by AMP-activated protein kinase, Trends Mol Med, 21, 571, 10.1016/j.molmed.2015.07.003

Zhang, 2016, Berberine prevents progression from hepatic steatosis to steatohepatitis and fibrosis by reducing endoplasmic reticulum stress, Sci Rep, 6, 20848, 10.1038/srep20848

Okla, 2015, Activation of Toll-like receptor 4 (TLR4) attenuates adaptive thermogenesis via endoplasmic reticulum stress, J Biol Chem, 290, 26476, 10.1074/jbc.M115.677724

Takahashi, 2000, Dietary n-3 fatty acids affect mRNA level of brown adipose tissue uncoupling protein 1, and white adipose tissue leptin and glucose transporter 4 in the rat, Br J Nutr, 84, 175, 10.1017/S0007114500001409

Oudart, 1997, Brown fat thermogenesis in rats fed high-fat diets enriched with n-3 polyunsaturated fatty acids, Int J Obes Relat Metab Disord, 21, 955, 10.1038/sj.ijo.0800500

Sadurskis, 1995, Polyunsaturated fatty acids recruit brown adipose tissue: increased UCP content and NST capacity, Am J Physiol, 269, E351

Bargut, 2016, Mice fed fish oil diet and upregulation of brown adipose tissue thermogenic markers, Eur J Nutr, 55, 159, 10.1007/s00394-015-0834-0

Zhao, 2014, Eicosapentaenoic acid promotes thermogenic and fatty acid storage capacity in mouse subcutaneous adipocytes, Biochem Biophys Res Commun, 450, 1446, 10.1016/j.bbrc.2014.07.010

Kim, 2015, Fish oil intake induces UCP1 upregulation in brown and white adipose tissue via the sympathetic nervous system, Sci Rep, 5, 18013, 10.1038/srep18013

Pahlavani, 2017, Eicosapentaenoic acid regulates brown adipose tissue metabolism in high-fat-fed mice and in clonal brown adipocytes, J Nutr Biochem, 39, 101, 10.1016/j.jnutbio.2016.08.012

Kim, 2016, Eicosapentaenoic acid potentiates brown thermogenesis through FFAR4-dependent up-regulation of miR-30b and miR-378, J Biol Chem, 291, 20551, 10.1074/jbc.M116.721480

Quesada-López, 2016, The lipid sensor GPR120 promotes brown fat activation and FGF21 release from adipocytes, Nat Commun, 7, 13479, 10.1038/ncomms13479

Martínez-Fernández, 2015, Omega-3 fatty acids and adipose tissue function in obesity and metabolic syndrome, Prostaglandins Other Lipid Mediat, 121, 24, 10.1016/j.prostaglandins.2015.07.003

Laiglesia, 2016, Eicosapentaenoic acid promotes mitochondrial biogenesis and beige-like features in subcutaneous adipocytes from overweight subjects, J Nutr Biochem, 37, 76, 10.1016/j.jnutbio.2016.07.019

Bonet, 2012, Lipid metabolism in mammalian tissues and its control by retinoic acid, Biochim Biophys Acta, 1821, 177, 10.1016/j.bbalip.2011.06.001

Alvarez, 1995, A novel regulatory pathway of brown fat thermogenesis. Retinoic acid is a transcriptional activator of the mitochondrial uncoupling protein gene, J Biol Chem, 270, 5666, 10.1074/jbc.270.10.5666

Murholm, 2013, Retinoic acid has different effects on UCP1 expression in mouse and human adipocytes, BMC Cell Biol, 14, 41, 10.1186/1471-2121-14-41

Mercader, 2010, Induction of uncoupling protein-1 in mouse embryonic fibroblast-derived adipocytes by retinoic acid, Obesity (Silver Spring), 18, 655, 10.1038/oby.2009.330

Felipe, 2004, Modulation of resistin expression by retinoic acid and vitamin A status, Diabetes, 53, 882, 10.2337/diabetes.53.4.882

Berry, 2009, All-trans-retinoic acid represses obesity and insulin resistance by activating both peroxisome proliferation-activated receptor beta/delta and retinoic acid receptor, Mol Cell Biol, 29, 3286, 10.1128/MCB.01742-08

Lowell, 2000, Towards a molecular understanding of adaptive thermogenesis, Nature, 404, 652, 10.1038/35007527

Teruel, 2003, Rosiglitazone and retinoic acid induce uncoupling protein-1 (UCP-1) in a p38 mitogen-activated protein kinase-dependent manner in fetal primary brown adipocytes, J Biol Chem, 278, 263, 10.1074/jbc.M207200200

Rial, 1999, Retinoids activate proton transport by the uncoupling proteins UCP1 and UCP2, EMBO J, 18, 5827, 10.1093/emboj/18.21.5827

Bonet, 2000, Opposite effects of feeding a vitamin A-deficient diet and retinoic acid treatment on brown adipose tissue uncoupling protein 1 (UCP1), UCP2 and leptin expression, J Endocrinol, 166, 511, 10.1677/joe.0.1660511

Mercader, 2006, Remodeling of white adipose tissue after retinoic acid administration in mice, Endocrinology, 147, 5325, 10.1210/en.2006-0760

Tourniaire, 2015, All-trans retinoic acid induces oxidative phosphorylation and mitochondria biogenesis in adipocytes, J Lipid Res, 56, 1100, 10.1194/jlr.M053652

Guo, 2016, Lipocalin 2, a regulator of retinoid homeostasis and retinoid-mediated thermogenic activation in adipose tissue, J Biol Chem, 291, 11216, 10.1074/jbc.M115.711556

Rupasinghe, 2016, Phytochemicals in regulating fatty acid beta-oxidation: potential underlying mechanisms and their involvement in obesity and weight loss, Pharmacol Ther, 165, 153, 10.1016/j.pharmthera.2016.06.005

Shen, 2015, Low level of trans-10, cis-12 conjugated linoleic acid decreases adiposity and increases browning independent of inflammatory signaling in overweight Sv129 mice, J Nutr Biochem, 26, 616, 10.1016/j.jnutbio.2014.12.016

Ribot, 2007, Effects of trans-10, cis-12 conjugated linoleic acid on the expression of uncoupling proteins in hamsters fed an atherogenic diet, Br J Nutr, 97, 1074, 10.1017/S0007114507682932

Nedergaard, 2013, UCP1 mRNA does not produce heat, Biochim Biophys Acta, 1831, 943, 10.1016/j.bbalip.2013.01.009

Lee, 2015, Activated type 2 innate lymphoid cells regulate beige fat biogenesis, Cell, 160, 74, 10.1016/j.cell.2014.12.011

Uhm, 2015, White, brown, and beige; type 2 immunity gets hot, Immunity, 42, 15, 10.1016/j.immuni.2015.01.001

Xu, 2003, Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance, J Clin Invest, 112, 1821, 10.1172/JCI200319451

Boström, 2012, A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis, Nature, 481, 463, 10.1038/nature10777

Borga, 2014, Brown adipose tissue in humans: detection and functional analysis using PET (positron emission tomography), MRI (magnetic resonance imaging), and DECT (dual energy computed tomography), Methods Enzymol, 537, 141, 10.1016/B978-0-12-411619-1.00008-2

Chen, 2016, Exosomal microRNA miR-92a concentration in serum reflects human brown fat activity, Nat Commun, 7, 11420, 10.1038/ncomms11420