Diet-induced insulin resistance altered cardiac GLUT4 and FATP/CD36 expression in rats

Beni-Suef University Journal of Basic and Applied Sciences
Oladele Afolabi1, Babatunde Alabi2, Olufemi Idowu Oluranti3
1Department of Physiology, Ladoke Akintola University of Technology, Ogbomoso, Nigeria
2Department of Pharmacology and Therapeutics, Bowen University College of Medicine, Iwo, Osun State, Nigeria
3Department of Physiology, Bowen University College of Medicine, Iwo, Osun State, Nigeria

Tóm tắt

Abstract Background Altered substrate transport protein expression is central to the effect of insulin resistance on cardiac metabolism. The present study was thus designed to investigate the comparative effects of high fat, high sucrose and salt-induced IR on cardiac expression of fatty acid transporter (FATP) and glucose transporter (GLUT4) in rats. Results Rats fed with high fat, high sucrose and salt diets developed impaired glucose tolerance (p > 0.05) and hyperinsulinemia (p < 0.05) compared with control group. Myocardial glucose transporter expression was significantly increased (p < 0.001 for salt-induced IR; p < 0.01 for sucrose-induced IR; p < 0.01 for fat-induced IR) across all IR groups compared with control. Fatty acid transporter expression was also increased (p < 0.001) in high salt diet-induced IR rats, and high fat diet-induced IR rats (p < 0.05). Conclusions Our results demonstrate that salt and not caloric excess has a potential role in IR alteration of myocardial substrate transport protein expression in the rat.

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Beni-Suef University Journal of Basic and Applied Sciences

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