Chẩn đoán và điều trị AML ở người lớn: Khuyến nghị ELN 2017 từ một nhóm chuyên gia quốc tế

Blood - Tập 129 Số 4 - Trang 424-447 - 2017
Hartmut Döhner1, Elihu H. Estey2, David Grimwade3, Sergio Amadori4, Frederick R. Appelbaum2, Thomas Büchner5, Hervé Dombret6, Benjamin L. Ebert7, Pierre Fenaux8, Richard A. Larson9, Ross L. Levine10, Francesco Lo‐Coco4, Tomoki Naoe11, Dietger Niederwieser12, Gert J. Ossenkoppele13, Miguel Á. Sanz14, Jorge Sierra15, Martin S. Tallman10, Hwei‐Fang Tien16, Andrew H. Wei17,18, Bob Löwenberg19, Clara D. Bloomfield20
1Department of Internal Medicine III, University of Ulm, Ulm, Germany
2Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA
3Department of Medical and Molecular Genetics, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom
4Department of Biomedicine and Prevention, Università di Roma “Tor Vergata”, Rome, Italy
5Department of Hematology/Oncology, University of Münster, Münster, Germany
6Institut Universitaire d’Hématologie, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, Paris, France;
7Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
8Service d'Hématologie, Hôpital Saint-Louis, Paris, France
9Department of Medicine, University of Chicago, Chicago, IL
10Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
11National Hospital Organization Nagoya Medical Center, Nagoya, Japan
12Department of Hematology, Oncology and Hemostasis, University of Leipzig, Leipzig, Germany
13Department of Haematology, Vrije Universiteit University Medical Center, Amsterdam, The Netherlands;
14Department of Hematology, University Hospital La Fe, University of Valencia, Valencia, Spain;
15Hematology Department, Hospital de la Santa Creu i Sant Pau, Jose Carreras Leukemia Research Institute, Barcelona, Spain;
16Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
17Australian Centre for Blood Diseases, Monash University, Melbourne, Australia
18Department of Clinical Hematology, The Alfred Hospital, Melbourne, Australia
19Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands; and
20The Ohio State University Comprehensive Cancer Center, Columbus, OH

Tóm tắt

Tóm tắt

Phiên bản đầu tiên của các khuyến nghị của Mạng lưới Bạch cầu Châu Âu (ELN) về chẩn đoán và quản lý bệnh bạch cầu tủy cấp (AML) ở người lớn, được công bố vào năm 2010, đã được các bác sĩ và nhà nghiên cứu chăm sóc bệnh nhân AML chấp nhận rộng rãi. Những tiến bộ gần đây, chẳng hạn như trong việc phát hiện cảnh quan gen của bệnh, trong việc phát triển các xét nghiệm di truyền và phát hiện bệnh còn sót lại tối thiểu (MRD), cũng như trong việc phát triển các tác nhân chống bạch cầu mới, đã thúc đẩy một nhóm quốc tế đưa ra các khuyến nghị cập nhật dựa trên chứng cứ và ý kiến chuyên gia. Các khuyến nghị bao gồm phiên bản sửa đổi của các thể loại di truyền ELN, một đề xuất cho một thể loại đáp ứng dựa trên tình trạng MRD, và các tiêu chí cho bệnh tiến triển.

Từ khóa


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