Diabetes, oxidative stress, and antioxidants: A review
Tóm tắt
Increasing evidence in both experimental and clinical studies suggests that oxidative stress plays a major role in the pathogenesis of both types of diabetes mellitus. Free radicals are formed disproportionately in diabetes by glucose oxidation, nonenzymatic glycation of proteins, and the subsequent oxidative degradation of glycated proteins. Abnormally high levels of free radicals and the simultaneous decline of antioxidant defense mechanisms can lead to damage of cellular organelles and enzymes, increased lipid peroxidation, and development of insulin resistance. These consequences of oxidative stress can promote the development of complications of diabetes mellitus. Changes in oxidative stress biomarkers, including superoxide dismutase, catalase, glutathione reductase, glutathione peroxidase, glutathione levels, vitamins, lipid peroxidation, nitrite concentration, nonenzymatic glycosylated proteins, and hyperglycemia in diabetes, and their consequences, are discussed in this review. In vivo studies of the effects of various conventional and alternative drugs on these biomarkers are surveyed. There is a need to continue to explore the relationship between free radicals, diabetes, and its complications, and to elucidate the mechanisms by which increased oxidative stress accelerates the development of diabetic complications, in an effort to expand treatment options. © 2003 Wiley Periodicals, Inc. J Biochem Mol Toxicol 17:24–38, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/jbt.10058
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Tài liệu tham khảo
Chang KC, 1993, Possible superoxide radical‐induced alteration of vascular reactivity in aortas from streptozotocin‐treated rats, J Pharmacol Exp Ther, 266, 992
Tsai EC, 1994, Reduced plasma peroxyl radical trapping capacity and increased susceptibility of LDL to oxidation in poorly controlled IDDM, Diabetes, 43, 1010, 10.2337/diab.43.8.1010
Kador PF, 1984, Diabetic and galactosaemic cataracts, Ciba Found Symp, 106, 110
Gonzalez AM, 1986, Effect of aldose reductase inhibitor (sorbinil) on integration of polyol pathway, pentose phosphate pathway, and glycolytic route in diabetic rat lens, Diabetes, 35, 1200, 10.2337/diab.35.11.1200
Williamson JR, 1993, Hyperglycemic pseudohypoxia and diabetic complications, Diabetes, 42, 801, 10.2337/diab.42.6.801
Ramalho JS, 1996, Role of glycation in human lens protein structure change, Eur J Ophthalmol, 6, 155, 10.1177/112067219600600211
Hounsom L, 1998, A lipoic acid‐gamma linolenic acid conjugate is effective against multiple indices of experimental diabetic neuropathy, Diabetologia, 41, 839, 10.1007/s001250050996
Fernyhough P, 1999, Aberrant neurofilament phosphorylation in sensory neurons of rats with diabetic neuropathy, Diabetes, 48, 881, 10.2337/diabetes.48.4.881
Asayama K, 1989, Antioxidant enzyme status and lipid peroxidation in various tissues of diabetic and starved rats, Diabetes Res, 12, 85
Pierrefiche G, 1993, Antioxidant activity of melatonin in mice, Res Commun Chem Pathol Pharmacol, 80, 211
Thompson KH, 1993, Effect of vanadyl sulfate feeding on susceptibility to peroxidative change in diabetic rats, Res Commun Chem Pathol Pharmacol, 80, 187
Kaul N, 1995, Probucol improves antioxidant activity and modulates development of diabetic cardiomyopathy, Nutrition, 11, 551
Obrosova IG, 1999, Effect of dietary taurine supplementation on GSH and NAD(P)‐redox status, lipid peroxidation, and energy metabolism in diabetic precataractous lens, Invest Ophthalm Vis Sci, 40, 680
Kocak G, 2000, α‐Lipoic acid treatment ameliorates metabolic parameters, blood pressure, vascular reactivity and morphology of vessels already damaged by streptozotocin‐diabetes, Diab Nutr Metab, 13, 308
Josephy PD, 1997, Molecular Toxicology
Gregus Z, 1996, Lipoic acid impairs glycine conjugation of benzoic acid and renal excretion of benzoylglycine, Drug Metab Disp, 24, 682
Martinoli L, 1993, Plasma retinol and alpha‐tocopherol concentrations in insulin‐dependent diabetes mellitus: Their relationship to microvascular complications, Int J Vitam Nutr Res, 63, 87
Garg MC, 1996, Effect of vitamin E supplementation on antioxidant status of diabetic rats, Med Sci Res, 24, 325
Brownlee M, 1990, Diabetes Mellitus: Theory and Practice, 279
Aruna RV, 1999, Effect of betacarotene on protein glycosylation in alloxan induced diabetic rats, Indian J Exp Biol, 37, 399
Lu SC, 1997, Progressive defect in biliary GSH secretion in streptozotocin‐induced diabetic rats, Am J Physiol, 272, G374
Watkins JB, 1995, Diabetes mellitus‐induced alterations of hepatobiliary function, Pharmacol Rev, 47, 1