Diabetes and Pregnancy: An Endocrine Society Clinical Practice Guideline

Journal of Clinical Endocrinology and Metabolism - Tập 98 Số 11 - Trang 4227-4249 - 2013
Ian Blumer1, Eran Hadar2, David R. Hadden3, Lois Jovanovič4, Jorge H. Mestman5, M. Hassan Murad6, Yariv Yogev2
1Charles H. Best Diabetes Centre (I.B.), Whitby, Ontario, Canada L1M 1Z5
2Helen Schneider Hospital for Women (E.H., Y.Y.), Petach Tikva 49100, Israel
3Royal Victoria Hospital (D.R.H.), Belfast BT12 6BA, Northern Ireland, United Kingdom
4Sansum Diabetes Research Institute (L.J.), Santa Barbara, California 93105
5University of Southern California (J. H. M.), Los Angeles, California 90089
6Knowledge and Evaluation Research Unit, Mayo Clinic (M. H. M.), Rochester, Minnesota 55905

Tóm tắt

Abstract Objective

Our objective was to formulate a clinical practice guideline for the management of the pregnant woman with diabetes.

Participants

The Task Force was composed of a chair, selected by the Clinical Guidelines Subcommittee of The Endocrine Society, 5 additional experts, a methodologist, and a medical writer.

Evidence

This evidence-based guideline was developed using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system to describe both the strength of recommendations and the quality of evidence.

Consensus Process

One group meeting, several conference calls, and innumerable e-mail communications enabled consensus for all recommendations save one with a majority decision being employed for this single exception.

Conclusions

Using an evidence-based approach, this Diabetes and Pregnancy Clinical Practice Guideline addresses important clinical issues in the contemporary management of women with type 1 or type 2 diabetes preconceptionally, during pregnancy, and in the postpartum setting and in the diagnosis and management of women with gestational diabetes during and after pregnancy.

Từ khóa


Tài liệu tham khảo

Institute of Medicine, 2002, Dietary Reference Intakes: Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids

Atkins, 2004, Grading quality of evidence and strength of recommendations, BMJ, 328, 1490, 10.1136/bmj.328.7454.1490

Swiglo, 2008, A case for clarity, consistency, and helpfulness: state-of-the-art clinical practice guidelines in endocrinology using the grading of recommendations, assessment, development, and evaluation system, J Clin Endocrinol Metab, 93, 666, 10.1210/jc.2007-1907

Guyatt, 2011, GRADE guidelines: 1. Introduction–GRADE evidence profiles and summary of findings tables, J Clin Epidemiol, 64, 383, 10.1016/j.jclinepi.2010.04.026

1979, Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. National Diabetes Data Group, Diabetes, 28, 1039, 10.2337/diab.28.12.1039

HAPO Study Cooperative Research Group, 2008, Hyperglycemia and adverse pregnancy outcomes, N Engl J Med, 358, 1991, 10.1056/NEJMoa0707943

De Groot, 2012, Management of thyroid dysfunction during pregnancy and postpartum: An Endocrine Society clinical practice guideline, J Clin Endocrinol Metab, 97, 2543, 10.1210/jc.2011-2803

Anwar, 2011, The effect of pre-pregnancy counselling for women with pre-gestational diabetes on maternal health status, Eur J Obstet Gynecol Reprod Biol, 155, 137, 10.1016/j.ejogrb.2010.12.017

Murphy, 2010, Effectiveness of a regional prepregnancy care program in women with type 1 and type 2 diabetes: Benefits beyond glycemic control, Diabetes Care, 33, 2514, 10.2337/dc10-1113

Ray, 2001, Preconception care and the risk of congenital anomalies in the offspring of women with diabetes mellitus: a meta-analysis, QJM, 94, 435, 10.1093/qjmed/94.8.435

Dicker, 1988, Spontaneous abortions in patients with insulin-dependent diabetes mellitus: the effect of preconceptional diabetic control, Am J Obstet Gynecol, 158, 1161, 10.1016/0002-9378(88)90245-1

Rosenn, 1991, Pre-conception management of insulin-dependent diabetes: improvement of pregnancy outcome, Obstet Gynecol, 77, 846

Holing, 2000, Preconception care of women with diabetes: the unrevealed obstacles, J Matern Fetal Med, 9, 10, 10.1002/(SICI)1520-6661(200001/02)9:1<10::AID-MFM4>3.0.CO;2-Z

Inkster, 2006, Poor glycated haemoglobin control and adverse pregnancy outcomes in type 1 and type 2 diabetes: systematic review of observational studies, BMC Pregnancy Childbirth, 6, 30, 10.1186/1471-2393-6-30

Nielsen, 2006, HbA1c in early diabetic pregnancy and pregnancy outcomes: a Danish population-based cohort study of 573 pregnancies in women with type 1 diabetes, Diabetes Care, 29, 2612, 10.2337/dc06-0914

Guerin, 2007, Use of maternal GHb concentration to estimate the risk of congenital anomalies in the offspring of women with prepregnancy diabetes, Diabetes Care, 30, 1920, 10.2337/dc07-0278

Suhonen, 2000, Glycaemic control during early pregnancy and fetal malformations in women with type I diabetes, Diabetologia, 43, 79, 10.1007/s001250050010

Bell, Peri-conception hyperglycaemia and nephropathy are associated with risk of congenital anomaly in women with pre-existing diabetes: a population-based cohort study. [published online ahead of print April 1, 2012], Diabetologia

Langer, 2000, Level of glycemia and perinatal outcome in pregestational diabetes, J Matern Fetal Med, 9, 35, 10.1002/(SICI)1520-6661(200001/02)9:1<35::AID-MFM8>3.0.CO;2-6

Jensen, 2009, Peri-conceptional A1C and risk of serious adverse pregnancy outcome in 933 women with type 1 diabetes, Diabetes Care, 32, 1046, 10.2337/dc08-2061

Persson, 1993, Hypoglycaemia in pregnancy, Baillieres Clin Endocrinol Metab, 7, 731, 10.1016/S0950-351X(05)80216-2

Rosenn, 1995, Hypoglycemia: the price of intensive insulin therapy for pregnant women with insulin-dependent diabetes mellitus, Obstet Gynecol, 85, 417, 10.1016/0029-7844(94)00415-A

Evers, 2002, Risk indicators predictive for severe hypoglycemia during the first trimester of Type 1 diabetic pregnancy, Diabetes Care, 25, 554, 10.2337/diacare.25.3.554

Nielsen, 2008, Hypoglycemia in pregnant women with type 1 diabetes: predictors and role of metabolic control, Diabetes Care, 31, 9, 10.2337/dc07-1066

Robertson, 2009, Severe hypoglycaemia during pregnancy in women with type 1 diabetes is common and planning pregnancy does not decrease the risk, Diabet Med, 26, 824, 10.1111/j.1464-5491.2009.02769.x

Confidential Enquiry into Maternal and Child Health (CEMACH), 2007, Diabetes in Pregnancy: Are We Providing the Best Care? Findings of a National Enquiry: England, Wales and Northern Ireland

1996, Pregnancy outcomes in the Diabetes Control and Complications Trial, Am J Obstet Gynecol, 174, 1343, 10.1016/S0002-9378(96)70683-X

Hod, 2008, Fetal and perinatal outcomes in type 1 diabetes pregnancy: a randomized study comparing insulin aspart with human insulin, Obstet Gynecol, 198, 186.e1

Mathiesen, 2007, Maternal glycemic control and hypoglycemia in type 1 diabetic pregnancy: a randomized trial of insulin aspart versus human insulin in 322 pregnant women, Diabetes Care, 30, 771, 10.2337/dc06-1887

Lapolla, 2008, Outcome of pregnancy in type 1 diabetic patients treated with insulin lispro or regular insulin: an Italian experience, Acta Diabetol, 45, 61, 10.1007/s00592-008-0024-0

Ratner, 2000, Less hypoglycemia with insulin glargine in intensive insulin therapy for type 1 diabetes. U.S. Study Group of Insulin Glargine in Type 1 Diabetes, Diabetes Care, 23, 639, 10.2337/diacare.23.5.639

Vague, 2003, Insulin detemir is associated with more predictable glycemic control and reduced risk of hypoglycemia than NPH insulin in patients with type 1 diabetes on a basal-bolus regimen with premeal insulin aspart, Diabetes Care, 26, 590, 10.2337/diacare.26.3.590

Gallen, 2008, Survey of glargine use in 115 pregnant women with type 1 diabetes, Diabet Med, 25, 165, 10.1111/j.1464-5491.2007.02339.x

Lapolla, 2009, Use of insulin detemir in pregnancy: a report on 10 type 1 diabetic women, Diabet Med, 26, 1181, 10.1111/j.1464-5491.2009.02852.x

Pöyhönen-Alho, 2007, Use of insulin glargine during pregnancy, Acta Obstet Gynecol Scand, 86, 1171, 10.1080/00016340701515282

Pollex, 2010, Insulin glargine safety in pregnancy: a transplacental transfer study, Diabetes Care, 33, 29, 10.2337/dc09-1045

Mathiesen, 2012, Maternal efficacy and safety outcomes in a randomized, controlled trial comparing insulin detemir with NPH insulin in 310 pregnant women with type 1 diabetes, Diabetes Care, 35, 2012, 10.2337/dc11-2264

Wilson, 2007, Pre-conceptional vitamin/folic acid supplementation 2007: the use of folic acid in combination with a multivitamin supplement for the prevention of neural tube defects and other congenital anomalies, J Obstet Gynaecol Can, 29, 1003, 10.1016/S1701-2163(16)32685-8

Diabetes Control and Complications Trial Research Group, 2000, Effect of pregnancy on microvascular complications in the Diabetes Control and Complications Trial. The Diabetes Control and Complications Trial Research Group, Diabetes Care, 23, 1084, 10.2337/diacare.23.8.1084

Chew, 1995, Metabolic control and progression of retinopathy. The Diabetes in Early Pregnancy Study. National Institute of Child Health and Human Development Diabetes in Early Pregnancy Study, Diabetes Care, 18, 631, 10.2337/diacare.18.5.631

Vestgaard, 2010, Pregnancy-induced sight-threatening diabetic retinopathy in women with type 1 diabetes, Diabet Med, 27, 431, 10.1111/j.1464-5491.2010.02958.x

Omori, 2005, Proposal for the reconsideration of the definition of gestational diabetes, Diabetes Care, 28, 2592, 10.2337/diacare.28.10.2592

Cundy, 2002, Hypertensive disorders of pregnancy in women with type 1 and type 2 diabetes, Diabet Med, 19, 482, 10.1046/j.1464-5491.2002.00729.x

Rosenn, 1992, Progression of diabetic retinopathy in pregnancy: association with hypertension in pregnancy, Am J Obstet Gynecol, 166, 1214, 10.1016/S0002-9378(11)90608-5

Lövestam-Adrian, 1997, Pre-eclampsia is a potent risk factor for deterioration of retinopathy during pregnancy in type 1 diabetic patients, Diabet Med, 14, 1059, 10.1002/(SICI)1096-9136(199712)14:12<1059::AID-DIA505>3.0.CO;2-8

Sibai, 2000, Risks of preeclampsia and adverse neonatal outcomes among women with pregestational diabetes mellitus. National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units, Am J Obstet Gynecol, 182, 364, 10.1016/S0002-9378(00)70225-0

Ekbom, 2001, Pregnancy outcome in type 1 diabetic women with microalbuminuria, Diabetes Care, 24, 1739, 10.2337/diacare.24.10.1739

Dunne, 1999, Pregnancy outcome in women with insulin-dependent diabetes mellitus complicated by nephropathy, QJM, 92, 451, 10.1093/qjmed/92.8.451

Leguizamon, 2000, Effect of medical therapy on progressive nephropathy: influence of pregnancy, diabetes and hypertension, J Matern Fetal Med, 9, 70, 10.1002/(SICI)1520-6661(200001/02)9:1<70::AID-MFM15>3.0.CO;2-#

Biesenbach, 1999, How pregnancy influences renal function in nephropathic type 1 diabetic women depends on their pre-conceptional creatinine clearance, J Nephrol, 12, 41

Gordon, 1996, Perinatal outcome and long-term follow-up associated with modern management of diabetic nephropathy, Obstet Gynecol, 87, 401, 10.1016/0029-7844(95)00420-3

Cooper, 2006, Major congenital malformations after first-trimester exposure to ACE inhibitors, N Engl J Med, 354, 2443, 10.1056/NEJMoa055202

Quan, 2006, Fetopathy associated with exposure to angiotensin converting enzyme inhibitors and angiotensin receptor antagonists, Early Hum Dev, 82, 23, 10.1016/j.earlhumdev.2005.11.001

Velázquez-Armenta, 2007, Angiotensin II receptor blockers in pregnancy: a case report and systematic review of the literature, Hypertens Pregnancy, 26, 51, 10.1080/10641950601147937

Bullo, 2012, Pregnancy outcome following exposure to angiotensin-converting enzyme inhibitors or angiotensin receptor antagonists: a systematic review, Hypertension, 60, 444, 10.1161/HYPERTENSIONAHA.112.196352

Magee, 2003, Serious perinatal complications of non-proteinuric hypertension: an international, multicentre, retrospective cohort study, J Obstet Gynaecol Can, 25, 372, 10.1016/S1701-2163(16)30579-5

American Diabetes Association, 2013, Standards of medical care in diabetes—2013, Diabetes Care, 36, S11, 10.2337/dc13-S011

Silfen, 1980, Maternal outcome in class H diabetes mellitus, Obstet Gynecol, 55, 749

Bagg, 1999, Pregnancy in women with diabetes and ischaemic heart disease, Aust N Z J Obstet Gynaecol, 39, 99, 10.1111/j.1479-828X.1999.tb03454.x

Roth, 2008, Acute myocardial infarction associated with pregnancy, J Am Coll Cardiol, 52, 171, 10.1016/j.jacc.2008.03.049

Edison, 2004, Mechanistic and epidemiologic considerations in the evaluation of adverse birth outcomes following gestational exposure to statins, Am J Med Genet A, 131, 287, 10.1002/ajmg.a.30386

Kazmin, 2007, Risks of statin use during pregnancy: a systematic review, J Obstet Gynaecol Can, 29, 906, 10.1016/S1701-2163(16)32656-1

Alvarez-Marfany, 1994, Long term prospective study of postpartum thyroid dysfunction in women with insulin dependent diabetes mellitus, J Clin Endocrinol Metab, 79, 10

Umpierrez, 2003, Thyroid dysfunction in patients with type 1 diabetes: a longitudinal study, Diabetes Care, 26, 1181, 10.2337/diacare.26.4.1181

Casey, 2005, Subclinical hypothyroidism and pregnancy outcomes, Obstet Gynecol, 105, 239, 10.1097/01.AOG.0000152345.99421.22

Glinoer, 1991, Pregnancy in patients with mild thyroid abnormalities: maternal and neonatal repercussions, J Clin Endocrinol Metab, 73, 421, 10.1210/jcem-73-2-421

Haddow, 1999, Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child, N Engl J Med, 341, 549, 10.1056/NEJM199908193410801

Leung, 1993, Perinatal outcome in hypothyroid pregnancies, Obstet Gynecol, 81, 349

Man, 1991, Maternal hypothyroxinemia: psychoneurological deficits of progeny, Ann Clin Lab Sci, 21, 227

International Association of Diabetes and Pregnancy Study Groups Consensus Panel, 2010, International Association of Diabetes and Pregnancy Study Groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy, Diabetes Care, 33, 676, 10.2337/dc09-1848

Prutsky, 2013, Screening of gestational diabetes: a systematic review and meta-analysis, J Clin Endocrinol Metab, 98

Landon, 2009, A multicenter, randomized trial of treatment for mild gestational diabetes, N Engl J Med, 361, 1339, 10.1056/NEJMoa0902430

Pettitt, 1980, Gestational diabetes: Infant and maternal complications of pregnancy in relation to third-trimester glucose tolerance in the Pima Indians, Diabetes Care, 3, 458, 10.2337/diacare.3.3.458

Jensen, 2008, Adverse pregnancy outcome in women with mild glucose intolerance: is there a clinically meaningful threshold value for glucose?, Acta Obstet Gynecol Scand, 87, 59, 10.1080/00016340701823975

Sermer, 1995, Impact of increasing carbohydrate intolerance on maternal-fetal outcomes in 3637 women without gestational diabetes. The Toronto Tri-Hospital Gestational Diabetes Project, Am J Obstet Gynecol, 173, 146, 10.1016/0002-9378(95)90183-3

Sacks, 1995, Toward universal criteria for gestational diabetes: the 75-gram glucose tolerance test in pregnancy, Am J Obstet Gynecol, 172, 607, 10.1016/0002-9378(95)90580-4

Ferrara, 2007, Pregnancy plasma glucose levels exceeding the American Diabetes Association thresholds, but below the National Diabetes Data Group thresholds for gestational diabetes mellitus, are related to the risk of neonatal macrosomia, hypoglycaemia and hyperbilirubinaemia, Diabetologia, 50, 298, 10.1007/s00125-006-0517-8

2011, Committee opinion no. 504: screening and diagnosis of gestational diabetes mellitus, Obstet Gynecol, 118, 751, 10.1097/AOG.0b013e3182310cc3

2013

HAPO Study Cooperative Research Group, 2009, Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study: associations with neonatal anthropometrics, Diabetes, 58, 453, 10.2337/db08-1112

Metzger, 1982, ’Accelerated starvation’ and the skipped breakfast in late normal pregnancy, Lancet, i, 588, 10.1016/S0140-6736(82)91750-0

Silverman, 1998, Long-term effects of the intrauterine environment: the Northwestern University Diabetes in Pregnancy Center, Diabetes Care, 21, B142

Crowther, 2005, Effect of treatment of gestational diabetes mellitus on pregnancy outcomes, N Engl J Med, 352, 2477, 10.1056/NEJMoa042973

Short, 2013, Postprandial improvement in insulin sensitivity after a single exercise session in adolescents with low aerobic fitness and physical activity, Pediatr Diabetes, 14, 129, 10.1111/j.1399-5448.2012.00900.x

Short, 2012, The acute and residual effect of a single exercise session on meal glucose tolerance in sedentary young adults, J Nutr Metab, 2012, 278678, 10.1155/2012/278678

Young, 1992, The effect of prior exercise on oral glucose tolerance in late gestational women, Eur J Appl Physiol Occup Physiol, 64, 430, 10.1007/BF00625062

Avery, 2001, Acute effect of exercise on blood glucose and insulin levels in women with gestational diabetes, J Matern Fetal Med, 10, 52, 10.1080/jmf.10.1.52.58-4

Jovanovic-Peterson, 1989, Randomized trial of diet versus diet plus cardiovascular conditioning on glucose levels in gestational diabetes, Am J Obstet Gynecol, 161, 415, 10.1016/0002-9378(89)90534-6

O'Sullivan, 1966, The potential diabetic and her treatment in pregnancy, Obstet Gynecol, 27, 683

Rowan, 2008, Metformin versus insulin for the treatment of gestational diabetes, N Engl J Med, 358, 2003, 10.1056/NEJMoa0707193

Langer, 2000, A comparison of glyburide and insulin in women with gestational diabetes mellitus, N Engl J Med, 343, 1134, 10.1056/NEJM200010193431601

Kjos, 1995, Predicting future diabetes in Latino women with gestational diabetes. Utility of early postpartum glucose tolerance testing, Diabetes, 44, 586, 10.2337/diab.44.5.586

Pallardo, 1999, Early postpartum metabolic assessment in women with prior gestational diabetes, Diabetes Care, 22, 1053, 10.2337/diacare.22.7.1053

Lauenborg, 2004, Increasing incidence of diabetes after gestational diabetes: a long-term follow-up in a Danish population, Diabetes Care, 27, 1194, 10.2337/diacare.27.5.1194

Kousta, 2006, The impact of ethnicity on glucose regulation and the metabolic syndrome following gestational diabetes, Diabetologia, 49, 36, 10.1007/s00125-005-0058-6

Bo, 2004, Prior gestational hyperglycemia: a long-term predictor of the metabolic syndrome, J Endocrinol Invest, 27, 629, 10.1007/BF03347494

Lauenborg, 2005, The prevalence of the metabolic syndrome in a Danish population of women with previous gestational diabetes mellitus is three-fold higher than in the general population, J Clin Endocrinol Metab, 90, 4004, 10.1210/jc.2004-1713

Schaefer-Graf, 2002, Clinical predictors for a high risk for the development of diabetes mellitus in the early puerperium in women with recent gestational diabetes mellitus, Am J Obstet Gynecol, 186, 751, 10.1067/mob.2002.121895

Holt, 2003, A postnatal fasting plasma glucose is useful in determining which women with gestational diabetes should undergo a postnatal oral glucose tolerance test, Diabet Med, 20, 594, 10.1046/j.1464-5491.2003.00974.x

Löbner, 2006, Predictors of postpartum diabetes in women with gestational diabetes mellitus, Diabetes, 55, 792, 10.2337/diabetes.55.03.06.db05-0746

Wein, 1997, Studies of postnatal diabetes mellitus in women who had gestational diabetes. Part 2. Prevalence and predictors of diabetes mellitus after delivery, Aust N Z J Obstet Gynaecol, 37, 420, 10.1111/j.1479-828X.1997.tb02450.x

Linné, 2002, Natural course of gestational diabetes mellitus: long term follow up of women in the SPAWN study, BJOG, 109, 1227, 10.1016/S1470-0328(02)01973-0

Aberg, 2002, Predictive factors of developing diabetes mellitus in women with gestational diabetes, Acta Obstet Gynecol Scand, 81, 11, 10.1046/j.0001-6349.2001.00000.x

Järvelä, 2006, Gestational diabetes identifies women at risk for permanent type 1 and type 2 diabetes in fertile age: predictive role of autoantibodies, Diabetes Care, 29, 607, 10.2337/diacare.29.03.06.dc05-1118

O'Sullivan, 1991, Diabetes mellitus after GDM, Diabetes, 40, 131, 10.2337/diab.40.2.S131

Stowers, 1985, Long range implications for the mother. The Aberdeen experience, Diabetes, 34, 106, 10.2337/diab.34.2.S106

Damm, 1998, Gestational diabetes mellitus and subsequent development of overt diabetes mellitus, Danish Med Bull, 45, 495

Pettitt, 2010, Maternal glucose at 28 weeks of gestation is not associated with obesity in 2-year-old offspring: the Belfast Hyperglycemia and Adverse Pregnancy Outcome (HAPO) family study, Diabetes Care, 33, 1219, 10.2337/dc09-2384

Prutsky, 2013, Glucose targets in pregnant women with diabetes: a systematic review and meta-analysis, J Clin Endocrinol Metab, 98

Chen, 2003, Continuous glucose monitoring for the evaluation and improved control of gestational diabetes mellitus, J Matern Fetal Neonatal Med, 14, 256, 10.1080/jmf.14.4.256.260

McLachlan, 2007, The role of continuous glucose monitoring in clinical decision-making in diabetes in pregnancy, Aust N Z J Obstet Gynaecol, 47, 186, 10.1111/j.1479-828X.2007.00716.x

Voelmle, 2007, Fetal outcomes and improved A1c values in pregnant women with type 1 diabetes using real-time continuous glucose sensors, Diabetes, 56, A117

Buchanan, 1994, Use of fetal ultrasound to select metabolic therapy for pregnancies complicated by mild gestational diabetes, Diabetes Care, 17, 275, 10.2337/diacare.17.4.275

Kjos, 2001, A randomized controlled trial using glycemic plus fetal ultrasound parameters versus glycemic parameters to determine insulin therapy in gestational diabetes with fasting hyperglycemia, Diabetes Care, 24, 1904, 10.2337/diacare.24.11.1904

American Diabetes Association, 1980, Summary and recommendations of the First International Conference-Workshop on Gestational Diabetes Mellitus, Diabetes Care, 3, 499

Frenkel, 1985, Summary and recommendations of the Second International Workshop-Conference on Gestational Diabetes, Diabetes, 34, S123, 10.2337/diab.34.2.S123

Metzger, 1998, Summary and recommendations of the Fourth International Workshop-Conference on Gestational Diabetes. The Organizing Committee, Diabetes Care, 21, B161

Langer, 1998, Maternal glycemic criteria for insulin therapy in gestational diabetes mellitus, Diabetes Care, 21, B91

Gunderson, 2004, Gestational diabetes and nutritional recommendations, Curr Diab Rep, 4, 377, 10.1007/s11892-004-0041-5

Franz, 1995, Effectiveness of medical nutrition therapy provided by dietitians in the management of non-insulin-dependent diabetes mellitus: a randomized, controlled clinical trial, J Am Diet Assoc, 95, 1009, 10.1016/S0002-8223(95)00276-6

Kulkarni, 1998, Nutrition Practice Guidelines for Type 1 Diabetes Mellitus positively affect dietitian practices and patient outcomes. The Diabetes Care and Education Dietetic Practice Group, J Am Diet Assoc, 98, 62, 10.1016/S0002-8223(98)00017-0

Reader, 2006, Impact of gestational diabetes mellitus nutrition practice guidelines implemented by registered dietitians on pregnancy outcomes, J Am Diet Assoc, 106, 1426, 10.1016/j.jada.2006.06.009

American Dietetic Association, 2002, Nutrition Practice Guidelines for Gestational Diabetes [CD-ROM]

Gunderson, 2004, Excess gains in weight and waist circumference associated with childbearing: The Coronary Artery Risk Development in Young Adults Study (CARDIA), Int J Obes Relat Metab Disord, 28, 525, 10.1038/sj.ijo.0802551

Callaway, 2006, The prevalence and impact of overweight and obesity in an Australian obstetric population, Med J Aust, 184, 56, 10.5694/j.1326-5377.2006.tb00115.x

Crane, 2009, The effect of gestational weight gain by body mass index on maternal and neonatal outcomes, J Obstet Gynaecol Can, 31, 28, 10.1016/S1701-2163(16)34050-6

Tennant, 2011, Maternal body mass index and the risk of fetal and infant death: a cohort study from the North of England, Hum Reprod, 26, 1501, 10.1093/humrep/der052

Bhattacharya, 2007, Effect of body mass index on pregnancy outcomes in nulliparous women delivering singleton babies, BMC Public Health, 7, 168, 10.1186/1471-2458-7-168

Magee, 1990, Metabolic effects of 1200-kcal diet in obese pregnant women with gestational diabetes, Diabetes, 39, 234, 10.2337/diab.39.2.234

IOM (Institute of Medicine) and NRC (National Research Council), 2009, Weight Gain During Pregnancy: Reexamining the Guidelines

Snyder, 1994, Predictors of infant birth weight in gestational diabetes, Am J Clin Nutr, 59, 1409, 10.1093/ajcn/59.6.1409

Knopp, 1991, Hypocaloric diets and ketogenesis in the management of obese gestational diabetic women, J Am Coll Nutr, 10, 649, 10.1080/07315724.1991.10718184

Algert, 1985, Moderate caloric restriction in obese women with gestational diabetes, Obstet Gynecol, 65, 487

Rizzo, 1991, Correlations between antepartum maternal metabolism and child intelligence, N Engl J Med, 325, 911, 10.1056/NEJM199109263251303

Jovanovic, 1998, The Diabetes in Early Pregnancy Study: β-hydroxybutyrate levels in type 1 diabetic pregnancy compared with normal pregnancy. NICHD-Diabetes in Early Pregnancy Study Group (DIEP). National Institute of Child Health and Development, Diabetes Care November, 21, 1978, 10.2337/diacare.21.11.1978

American Diabetes Association, 2000, American Diabetes Association: gestational diabetes (position statement), Diabetes Care, 23, S77

American Diabetes Association, 2004, Gestational diabetes, Diabetes Care, 27, S88, 10.2337/diacare.27.2007.S88

Tieu, 2008, Dietary advice in pregnancy for preventing gestational diabetes, Cochrane Database Syst Rev, 2, CD006674

Fraser, 1983, A controlled trial of a high dietary fibre intake in pregnancy—effects on plasma glucose and insulin levels, Diabetologia, 25, 238, 10.1007/BF00279936

Jovanovic-Peterson, 1991, Maternal postprandial glucose levels and infant birth weight: the Diabetes in Early Pregnancy Study. The National Institute of Child Health and Human Development–Diabetes in Early Pregnancy Study, Am J Obstet Gynecol, 164, 103, 10.1016/0002-9378(91)90637-7

Brand-Miller, 2003, Low-glycemic index diets in the management of diabetes: a meta-analysis of randomized controlled trials, Diabetes Care, 26, 2261, 10.2337/diacare.26.8.2261

Bartley, 2008, Long-term efficacy and safety of insulin detemir compared to neutral protamine Hagedorn insulin in patients with type 1 diabetes using a treat-to-target basal-bolus regimen with insulin aspart at meals: a 2-year, randomized, controlled trial, Diabet Med, 25, 442, 10.1111/j.1464-5491.2007.02407.x

Hermansen, 2004, Insulin analogues (insulin detemir and insulin aspart) versus traditional human insulins (NPH insulin and regular human insulin) in basal-bolus therapy for patients with type 1 diabetes, Diabetologia, 47, 622, 10.1007/s00125-004-1365-z

Russell-Jones, 2004, Effects of QD insulin detemir or neutral protamine Hagedorn on blood glucose control in patients with type I diabetes mellitus using a basal-bolus regimen, Clin Ther, 26, 724, 10.1016/S0149-2918(04)90072-0

Mathiesen, 2011, Basal insulin analogues in diabetic pregnancy: a literature review and baseline results of a randomised, controlled trial in type 1 diabetes, Diabetes Metab Res Rev, 27, 543, 10.1002/dmrr.1213

Price, 2007, Use of insulin glargine during pregnancy: a case-control pilot study, BJOG, 114, 453, 10.1111/j.1471-0528.2006.01216.x

Fang, 2009, Insulin glargine compared with neutral protamine Hagedorn insulin in the treatment of pregnant diabetics, J Matern Fetal Neonatal Med, 22, 249, 10.1080/14767050802638170

Smith, 2009, Insulin glargine versus neutral protamine Hagedorn insulin for treatment of diabetes in pregnancy, Am J Perinatol, 26, 57, 10.1055/s-0028-1095181

Egerman, 2009, Perinatal outcomes in pregnancies managed with antenatal insulin glargine, Am J Perinatol, 26, 591, 10.1055/s-0029-1220782

Imbergamo, 2008, Use of glargine in pregnant women with type 1 diabetes mellitus: a case-control study, Clin Ther, 30, 1476, 10.1016/j.clinthera.2008.08.013

Kurtzhals, 2000, Correlations of receptor binding and metabolic and mitogenic potencies of insulin analogs designed for clinical use, Diabetes, 49, 999, 10.2337/diabetes.49.6.999

Lauszus, 2007, The clinical significance of IGF-I in maternal serum during pregnancy in type 1 diabetes, Curr Diabetes Rev, 3, 194, 10.2174/157339907781368922

Thrailkill, 1999, Cotherapy with recombinant human insulin-like growth factor I and insulin improves glycemic control in type 1 diabetes. RhIGF-I in IDDM Study Group. RhIGF-I in IDDM Study Group, Diabetes Care, 22, 585, 10.2337/diacare.22.4.585

Hofmann, 2002, Evaluation of the reproductive toxicity and embryotoxicity of insulin glargine (LANTUS) in rats and rabbits, Int J Toxicol, 21, 181, 10.1080/10915810290096315

Lepercq, 2010, Use of insulin glargine throughout pregnancy in 102 women with type 1 diabetes, Diabetes Metab, 36, 209, 10.1016/j.diabet.2009.11.008

Negrato, 2010, Glargine vs. NPH insulin therapy in pregnancies complicated by diabetes: an observational cohort study, Diabetes Res Clin Pract, 89, 46, 10.1016/j.diabres.2010.03.015

Pratoomsoot, 2009, An estimation of the long-term clinical and economic benefits of insulin lispro in type 1 diabetes in the UK, Diabet Med, 26, 803, 10.1111/j.1464-5491.2009.02775.x

Loukovaara, 2003, Progression of retinopathy during pregnancy in type 1 diabetic women treated with insulin lispro, Diabetes Care, 26, 1193, 10.2337/diacare.26.4.1193

Durnwald, 2008, A comparison of lispro and regular insulin for the management of type 1 and type 2 diabetes in pregnancy, J Matern Fetal Neonatal Med, 21, 309, 10.1080/14767050802022797

Bhattacharyya, 2001, Insulin lispro and regular insulin in pregnancy, QJM, 94, 255, 10.1093/qjmed/94.5.255

Aydin, 2008, Is insulin lispro safe in pregnant women: does it cause any adverse outcomes on infants or mothers?, Diabetes Res Clin Pract, 80, 444, 10.1016/j.diabres.2008.02.004

Persson, 2002, Insulin lispro therapy in pregnancies complicated by type 1 diabetes mellitus, Diabetes Res Clin Pract, 58, 115, 10.1016/S0168-8227(02)00141-9

Cypryk, 2004, Pregnancy complications and perinatal outcome in diabetic women treated with Humalog (insulin lispro) or regular human insulin during pregnancy, Med Sci Monit, 10, PI29

Wyatt, 2005, Congenital anomaly rate in offspring of mothers with diabetes treated with insulin lispro during pregnancy, Diabet Med, 22, 803, 10.1111/j.1464-5491.2004.01498.x

Bhattacharyya, 1999, Insulin lispro, pregnancy, and retinopathy, Diabetes Care, 22, 2101, 10.2337/diacare.22.12.2101

Buchbinder, 2000, Is insulin lispro associated with the development or progression of diabetic retinopathy during pregnancy?, Am J Obstet Gynecol, 183, 1162, 10.1067/mob.2000.108893

Hiéronimus, 2005, Pregnancy in type 1 diabetes: insulin pump versus intensified conventional therapy [in French], Gynecol Obstet Fertil, 33, 389, 10.1016/j.gyobfe.2005.04.020

Lapolla, 2003, Analysis of outcome of pregnancy in type 1 diabetics treated with insulin pump or conventional insulin therapy, Acta Diabetol, 40, 143, 10.1007/s00592-003-0103-1

Misso, 2010, Continuous subcutaneous insulin infusion (CSII) versus multiple insulin injections for type 1 diabetes, Cochrane Database Syst Rev, 1, CD005103

Mukhopadhyay, 2007, Continuous subcutaneous insulin infusion vs intensive conventional insulin therapy in pregnant diabetic women: a systematic review and meta-analysis of randomized, controlled trials, Am J Obstet Gynecol, 197, 447, 10.1016/j.ajog.2007.03.062

Gabbe, 2000, New concepts and applications in the use of the insulin pump during pregnancy, J Matern Fetal Med, 9, 42, 10.1002/(SICI)1520-6661(200001/02)9:1<42::AID-MFM9>3.0.CO;2-B

Simmons, 2001, Use of insulin pumps in pregnancies complicated by type 2 diabetes and gestational diabetes in a multiethnic community, Diabetes Care, 24, 2078, 10.2337/diacare.24.12.2078

Chen, 2007, Level of glycemic control and pregnancy outcome in type 1 diabetes: a comparison between multiple daily insulin injections and continuous subcutaneous insulin infusions, Am J Obstet Gynecol, 197, 404.e1, 10.1016/j.ajog.2007.06.007

Kremer, 2004, Glyburide for the treatment of gestational diabetes, Am J Obstet Gynecol, 190, 1438, 10.1016/j.ajog.2004.02.032

Jacobson, 2005, Comparison of glyburide and insulin for the management of gestational diabetes in a large managed care organization, Am J Obstet Gynecol, 193, 118, 10.1016/j.ajog.2005.03.018

Ramos, 2007, Comparison of glyburide and insulin for the management of gestational diabetics with markedly elevated oral glucose challenge test and fasting hyperglycemia, J Perinatol, 27, 262, 10.1038/sj.jp.7211683

Lain, 2009, Neonatal adiposity following maternal treatment of gestational diabetes with glyburide compared with insulin, Am J Obstet Gynecol, 200, 501, 10.1016/j.ajog.2009.02.038

Hebert, 2009, Are we optimizing gestational diabetes treatment with glyburide? The pharmacologic basis for better clinical practice, Clin Pharmacol Ther, 85, 607, 10.1038/clpt.2009.5

Dhulkotia, 2009, Oral hypoglycemia agents vs insulin in management of gestational diabetes: a systemic review and metaanalysis, Am J Obstet Gynecol, 203, 457.e1, 10.1016/j.ajog.2010.06.044

Conway, 2004, Use of glyburide for the treatment of gestational diabetes: the San Antonio experience, J Matern Fetal Neonatal Med, 15, 51, 10.1080/14767050310001650725

Rochon, 2006, Glyburide for the management of gestational diabetes: risk factors predictive of failure and associated pregnancy outcomes, Am J Obstet Gynecol, 195, 1090, 10.1016/j.ajog.2006.07.029

Yogev, 2011, Glyburide in gestational diabetes—prediction of treatment failure, J Matern Fetal Neonatal Med, 24, 842, 10.3109/14767058.2010.531323

Kahn, 2006, Predictors of glyburide failure in the treatment of gestational diabetes, Obstet Gynecol, 107, 1303, 10.1097/01.AOG.0000218704.28313.36

Chmait, 2004, Prospective observational study to establish predictors of glyburide success in women with gestational diabetes mellitus, J Perinatol, 24, 617, 10.1038/sj.jp.7211147

Goetzl, 2002, Glyburide compared to insulin for the treatment of gestational diabetes mellitus: a cost analysis, J Perinatol, 22, 403, 10.1038/sj.jp.7210759

Gutzin, 2003, The safety of oral hypoglycemic agents in the first trimester of pregnancy: a meta-analysis, Can J Clin Pharmacol, 10, 179

Baillargeon, 2004, Effects of metformin and rosiglitazone, alone and in combination, in nonobese women with polycystic ovary syndrome and normal indices of insulin sensitivity, Fertil Steril, 82, 893, 10.1016/j.fertnstert.2004.02.127

Gagnon, 2007, Suitability of recommended limits for fasting glucose tests in women with polycystic ovary syndrome, CMAJ, 176, 933, 10.1503/cmaj.060607

Genazzani, 2010, Use of metformin in the treatment of polycystic ovary syndrome, Womens Health (Lond Engl), 6, 577, 10.2217/WHE.10.43

Glueck, 2004, Metformin, pre-eclampsia, and pregnancy outcomes in women with polycystic ovary syndrome, Diabet Med, 21, 829, 10.1111/j.1464-5491.2004.01251.x

Gilbert, 2006, Pregnancy outcome after first-trimester exposure to metformin: a meta-analysis, Fertil Steril, 86, 658, 10.1016/j.fertnstert.2006.02.098

Salvesen, 2007, Metformin treatment in pregnant women with polycystic ovary syndrome–is reduced complication rate mediated by changes in the uteroplacental circulation?, Ultrasound Obstet Gynecol, 29, 433, 10.1002/uog.3965

Bolton, 2009, Continuation of metformin in the first trimester of women with polycystic ovarian syndrome is not associated with increased perinatal morbidity, Eur J Pediatr, 168, 203, 10.1007/s00431-008-0737-7

Charles, 2006, Population pharmacokinetics of metformin in late pregnancy, Ther Drug Monit, 28, 67, 10.1097/01.ftd.0000184161.52573.0e

Eyal, 2010, Pharmacokinetics of metformin during pregnancy, Drug Metab Dispos, 38, 833, 10.1124/dmd.109.031245

Balsells, 2000, Gestational diabetes mellitus: metabolic control during labour, Diabetes Nutr Metab, 13, 257

Andersen, 1985, Influence of the maternal plasma glucose concentration at delivery on the risk of hypoglycaemia in infants of insulin-dependent diabetic mothers, Acta Paediatr Scand, 74, 268, 10.1111/j.1651-2227.1985.tb10963.x

Miodovnik, 1987, Management of the insulin-dependent diabetic during labor and delivery. Influences on neonatal outcome, Am J Perinatol, 4, 106, 10.1055/s-2007-999750

Curet, 1997, Relative effects of antepartum and intrapartum maternal blood glucose levels on incidence of neonatal hypoglycemia, J Perinatol, 17, 113

Lean, 1990, Insulin management during labour and delivery in mothers with diabetes, Diabet Med, 7, 162, 10.1111/j.1464-5491.1990.tb01352.x

Feldberg, 1988, Intrapartum management of insulin-dependent diabetes mellitus (IDDM) gestants. A comparative study of constant intravenous insulin infusion and continuous subcutaneous insulin infusion pump (CSIIP), Acta Obstet Gynecol Scand, 67, 333

Mimouni, 1987, Perinatal asphyxia in infants of diabetic mothers is associated with maternal vasculopathy and hyperglycaemia in labour, Neonat Epidemiol Follow-up, 400A

Mayer-Davis, 2006, Breast feeding and risk for childhood obesity: does diabetes or obesity status matter?, Diabetes Care October, 2231, 10.2337/dc06-0974

Schaefer-Graf, 2006, Association of breast-feeding and early childhood overweight in children from mothers with gestational diabetes mellitus, Diabetes Care, 29, 1105, 10.2337/dc05-2413

Gunderson, 2007, Breastfeeding after gestational diabetes pregnancy: subsequent obesity and type 2 diabetes in women and their offspring, Diabetes Care, 30, S161, 10.2337/dc07-s210

Plagemann, 2002, Long-term impact of neonatal breast-feeding on body weight and glucose tolerance in children of diabetic mothers, Diabetes Care, 25, 16, 10.2337/diacare.25.1.16

Rodekamp, 2005, Long-term impact of breast-feeding on body weight and glucose tolerance in children of diabetic mothers: role of the late neonatal period and early infancy, Diabetes Care, 28, 1457, 10.2337/diacare.28.6.1457

Mayer-Davis, 2006, Breast-feeding and risk for childhood obesity: does maternal diabetes or obesity status matter?, Diabetes Care, 29, 2231, 10.2337/dc06-0974

Pettitt, 1997, Breastfeeding and incidence of non-insulin-dependent diabetes mellitus in Pima Indians, Lancet, 350, 166, 10.1016/S0140-6736(96)12103-6

Pettitt, 1998, Long-term effects of the intrauterine environment, birth weight, and breast-feeding in Pima Indians, Diabetes Care, 21, B138

Young, 2002, Type 2 diabetes mellitus in children: prenatal and early infancy risk factors among native Canadians, Arch Pediatr Adolesc Med, 156, 651, 10.1001/archpedi.156.7.651

Virtanen, 1993, Early introduction of dairy products associated with increased risk of IDDM in Finnish children. The Childhood in Diabetes in Finland Study Group, Diabetes, 42, 1786, 10.2337/diab.42.12.1786

O'Reilly, 2012, Breast-feeding is associated with reduced postpartum maternal glucose intolerance after gestational diabetes, Ir Med J, 105, 31

Owen, 2006, Does breastfeeding influence risk of type 2 diabetes in later life? A quantitative analysis of published evidence, Am J Clin Nutr, 84, 1043, 10.1093/ajcn/84.5.1043

Glueck, 2007, Metformin before and during pregnancy and lactation in polycystic ovary syndrome, Expert Opin Drug Saf, 6, 191, 10.1517/14740338.6.2.191

Glueck, 2006, Growth, motor, and social development in breast- and formula-fed infants of metformin-treated women with polycystic ovary syndrome, J Pediatr, 148, 628, 10.1016/j.jpeds.2006.01.011

Feig, 2005, Transfer of glyburide and glipizide into breast milk, Diabetes Care, 28, 1851, 10.2337/diacare.28.8.1851

Glatstein, 2009, Use of hypoglycemic drugs during lactation, Can Fam Physician, 55, 371

Petersen, 1994, Effects of contraceptive steroids on cardiovascular risk factors in women with insulin-dependent diabetes mellitus, Am J Obstet Gynecol, 171, 400, 10.1016/S0002-9378(94)70041-9

Garg, 1994, Oral contraceptives and renal and retinal complications in young women with insulin-dependent diabetes mellitus, JAMA, 271, 1099, 10.1001/jama.1994.03510380055037

Klein, 1990, Oral contraceptives in women with diabetes, Diabetes Care, 13, 895, 10.2337/diacare.13.8.895

Skouby, 1985, Triphasic oral contraception: Metabolic effects in normal women and those with previous gestational diabetes, Am J Obstet Gynecol, 153, 495, 10.1016/0002-9378(85)90460-0

Kjos, 1990, Effect of low dose oral contraceptives on carbohydrate metabolism in women with recent gestational diabetes: results of a controlled, randomized, prospective study, Am J Obstet Gynecol, 163, 1882, 10.1016/0002-9378(90)90757-X

Kjos, 1998, Contraception and the risk of type 2 diabetes mellitus in Latina women with prior gestational diabetes mellitus, JAMA, 280, 533, 10.1001/jama.280.6.533

Skouby, 1987, Oral contraception and insulin sensitivity: in vivo assessment in normal women and women with previous gestational diabetes, J Clin Endocrinol Metab, 64, 519, 10.1210/jcem-64-3-519

Creasy, 2003, Transdermal contraceptive patch delivering norelgestromin and ethinyl estradiol. Effects on the lipid profile, J Reprod Med, 48, 179

Weisberg, 1999, Efficacy, bleeding patterns, and side effects of a 1-year contraceptive vaginal ring, Contraception, 59, 311, 10.1016/S0010-7824(99)00035-9

Skouby, 1984, Consequences of intrauterine contraception in diabetic women, Fertil Steril, 42, 568, 10.1016/S0015-0282(16)48140-9

Kimmerle, 1995, Intrauterine devices are safe and effective contraceptives for type I diabetic women, Diabetes Care, 18, 1506, 10.2337/diacare.18.11.1506b

Kjos, 1994, The copper T380A intrauterine device in women with type II diabetes mellitus, Obstet Gynecol, 84, 1006

Sturridge, 1996, A risk-benefit assessment of the levonorgestrel-releasing intrauterine system, Drug Saf, 15, 430, 10.2165/00002018-199615060-00006

Rogovskaya, 2005, Effect of a levonorgestrel intrauterine system on women with type 1 diabetes: a randomized trial, Obstet Gynecol, 105, 811, 10.1097/01.AOG.0000156301.11939.56

Petersen, 2002, Pharmacodynamic effects of oral contraceptive steroids on biochemical markers for arterial thrombosis. Studies in non-diabetic women and in women with insulin-dependent diabetes mellitus, Dan Med Bull, 49, 43

Godsland, 1990, The effects of different formulations of oral contraceptive agents on lipid and carbohydrate metabolism, N Engl J Med, 323, 1375, 10.1056/NEJM199011153232003

Kim, 2011, Effect of levothyroxine treatment on in vitro fertilization and pregnancy outcome in infertile women with subclinical hypothyroidism undergoing in vitro fertilization/intracytoplasmic sperm injection, Fertil Steril, 95, 1650, 10.1016/j.fertnstert.2010.12.004

Bech, 1991, Thyroid dysfunction and autoimmune manifestations in insulin-dependent diabetes during and after pregnancy, Acta Endocrinol (Copenh), 124, 534, 10.1530/acta.0.1240534