Development of a Conditionally Replicating Pseudorabies Virus for HER-2/neu-overexpressing Bladder Cancer Therapy

Jimenez, 2001, Her-2/neu overexpression in muscle-invasive urothelial carcinoma of the bladder: prognostic significance and comparative analysis in primary and metastatic tumors, Clin Cancer Res, 7, 2440 Kruger, 2002, HER2 overexpression in muscle-invasive urothelial carcinoma of the bladder: prognostic implications, Int J Cancer, 102, 514, 10.1002/ijc.10731 Gandour-Edwards, 2002, Does HER2/neu expression provide prognostic information in patients with advanced urothelial carcinoma?, Cancer, 95, 1009, 10.1002/cncr.10808 Kruger, 2002, Overexpression of c-erbB-2 oncoprotein in muscle-invasive bladder carcinoma: relationship with gene amplification, clinicopathological parameters and prognostic outcome, Int J Oncol, 21, 981 Yu, 2000, Overexpression of ErbB2 in cancer and ErbB2-targeting strategies, Oncogene, 19, 6115, 10.1038/sj.onc.1203972 Harris, 1994, Gene therapy for cancer using tumour-specific prodrug activation, Gene Ther, 1, 170 Enquist, 1998, Infection and spread of alphaherpesviruses in the nervous system, Adv Virus Res, 51, 237, 10.1016/S0065-3527(08)60787-3 Hampl, 1984, Characterization of the envelope proteins of pseudorabies virus, J Virol, 52, 583, 10.1128/JVI.52.2.583-590.1984 Wathen, 1984, Isolation, characterization, and physical mapping of a pseudorabies virus mutant containing antigenically altered gp50, J Virol, 51, 57, 10.1128/JVI.51.1.57-62.1984 Rauh, 1991, Pseudorabies virus glycoproteins gII and gp50 are essential for virus penetration, J Virol, 65, 5348, 10.1128/JVI.65.10.5348-5356.1991 Peeters, 1993, Envelope glycoprotein gp50 of pseudorabies virus is essential for virus entry but is not required for viral spread in mice, J Virol, 67, 170, 10.1128/JVI.67.1.170-177.1993 Mulder, 1996, Glycoprotein D-negative pseudorabies virus can spread transneuronally via direct neuron-to-neuron transmission in its natural host, the pig, but not after additional inactivation of gE or gI, J Virol, 70, 2191, 10.1128/JVI.70.4.2191-2200.1996 Mettenleiter, 1987, Role of a structural glycoprotein of pseudorabies in virus virulence, J Virol, 61, 4030, 10.1128/JVI.61.12.4030-4032.1987 Mulder, 1994, Glycoprotein gE-negative pseudorabies virus has a reduced capability to infect second- and third-order neurons of the olfactory and trigeminal routes in the porcine central nervous system, J Gen Virol, 75, 3095, 10.1099/0022-1317-75-11-3095 Babic, 1996, Deletion of glycoprotein gE reduces the propagation of pseudorabies virus in the nervous system of mice after intranasal inoculation, Virology, 219, 279, 10.1006/viro.1996.0247 McGregor, 1985, Vaccination of swine with thymidine kinase-deficient mutants of pseudorabies virus, Am J Vet Res, 46, 1494 Ferrari, 2000, A comparative study of pseudorabies virus (PRV) strains with defects in thymidine kinase and glycoprotein genes, J Comp Pathol, 123, 152, 10.1053/jcpa.2000.0406 Mulder, 1995, Role of viral proteins and concanavalin A in in vitro replication of pseudorabies virus in porcine peripheral blood mononuclear cells, J Gen Virol, 76, 1433, 10.1099/0022-1317-76-6-1433 Martuza, 1991, Experimental therapy of human glioma by means of a genetically engineered virus mutant, Science, 252, 854, 10.1126/science.1851332 Kooby, 1999, Oncolytic viral therapy for human colorectal cancer and liver metastases using a multi-mutated herpes simplex virus type-1 (G207), FASEB J, 13, 1325, 10.1096/fasebj.13.11.1325 Rampling, 2000, Toxicity evaluation of replication-competent herpes simplex virus (ICP 34.5 null mutant 1716) in patients with recurrent malignant glioma, Gene Ther, 7, 859, 10.1038/sj.gt.3301184 Markert, 2000, Conditionally replicating herpes simplex virus mutant, G207 for the treatment of malignant glioma: results of a phase I trial, Gene Ther, 7, 867, 10.1038/sj.gt.3301205 Boldogkoi, 2002, Evaluation of pseudorabies virus as a gene transfer vector and an oncolytic agent for human tumor cells, Anticancer Res, 22, 2153 Pritchett, 1984, Comparison of the genomes of pseudorabies (Aujeszky's disease) virus strains by restriction endonuclease analysis, Am J Vet Res, 45, 2486 Shiau, 2002, A simple selection system for construction of recombinant gD-negative pseudorabies virus as a vaccine vector, Vaccine, 20, 1186, 10.1016/S0264-410X(01)00426-1 Slamon, 2001, Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2, N Engl J Med, 344, 783, 10.1056/NEJM200103153441101 Yu, 1990, Transcriptional repression of the neu protooncogene by the adenovirus 5 E1A gene products, Proc Natl Acad Sci USA, 87, 4499, 10.1073/pnas.87.12.4499 Hudson, 1990, Structure and inducible regulation of the human c-erb B2/neu promoter, J Biol Chem, 265, 4389, 10.1016/S0021-9258(19)39577-8 Wollmann, 2005, Targeting human glioblastoma cells: comparison of nine viruses with oncolytic potential, J Virol, 79, 6005, 10.1128/JVI.79.10.6005-6022.2005 Shiau, 2005, Novel strategy for generation and titration of recombinant adeno-associated virus vectors, J Virol, 79, 193, 10.1128/JVI.79.1.193-201.2005 Shiau, 2001, Prothymosin α enhances protective immune responses induced by oral DNA vaccination against pseudorabies delivered by Salmonella choleraesuis, Vaccine, 19, 3947, 10.1016/S0264-410X(01)00130-X Lin, 2000, Establishment and characterization of a cell line (HCDB-1) derived from a hamster buccal pouch carcinoma induced by DMBA and Taiwanese betel quid extract, Proc Natl Sci Counc Repub China B, 24, 129 Lin, 2000, The N-terminal common domain of simian virus 40 large T and small t antigens acts as a transformation suppressor of the HER-2/neu oncogene, Oncogene, 19, 2704, 10.1038/sj.onc.1203582 Thomson, 1998, pMECA: a cloning plasmid with 44 unique restriction sites that allows selection of recombinants based on colony size, Biotechniques, 24, 922, 10.2144/98246bm04 Morgenstern, 1990, A series of mammalian expression vectors and characterisation of their expression of a reporter gene in stably and transiently transfected cells, Nucleic Acids Res, 18, 1068, 10.1093/nar/18.4.1068 Yoon, 2005, Molecular survey of latent pseudorabies virus infection in nervous tissues of slaughtered pigs by nested and real-time PCR, J Microbiol, 43, 430 Klupp, 2004, Complete, annotated sequence of the pseudorabies virus genome, J Virol, 78, 424, 10.1128/JVI.78.1.424-440.2004 Sambrook, 1989