Phát triển và xác thực một hệ thống chấm điểm tiên lượng cho bệnh nhân mắc bệnh bạch cầu tủy mãn tính đơn nhân

Blood - Tập 121 - Trang 3005-3015 - 2013
Esperanza Such1,2, Ulrich Germing, Luca Malcovati3, José Cervera1,2, Andrea Kuendgen4, Matteo G. Della Porta3, Benet Nomdedeu1,5, Leonor Arenillas1,6, Elisa Luño1,7, Blanca Xicoy1,8, Mari L. Amigo1,9, David Valcarcel1,10, Kathrin Nachtkamp4, Ilaria Ambaglio3, Barbara Hildebrandt11, Ignacio Lorenzo1,2, Mario Cazzola3, Guillermo Sanz1,2
1The Spanish MDS cooperative group, Valencia, Spain
2Department of Hematology, Hospital Universitario La Fe, Valencia, Spain
3Department of Hematology Oncology, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo and University of Pavia, Pavia, Italy
4Department of Hematology, Oncology and Clinical Immunology, Heinrich-Heine-University, Düsseldorf, Germany
5Department of Hematology, Hospital Clinic, Barcelona, Spain;
6Laboratori de Citologia Hematològica, Servei de Patologia, Hospital del Mar, and Hospital del Mar Research Institute, Barcelona, Spain
7Department of Hematology, Hospital Central de Asturias, Oviedo, Spain
8Department of Hematology, Hospital Germans Trias i Pujol and Institut Català d'Oncologia-José Carreras Leukemia Research Institute, Badalona, Spain
9Department of Hematology, Hospital Morales Meseguer, Murcia, Spain
10Department of Hematology, Hospital Universitario Vall D'Hebron, Barcelona, Spain; and
11Institute of Human Genetics, Heinrich-Heine-University, Düsseldorf, Germany

Tóm tắt

Các điểm chính CMML là một rối loạn không đồng nhất với tiên lượng rất biến đổi, rõ ràng cần có một hệ thống chấm điểm tiên lượng cụ thể và được chấp nhận rộng rãi. CPSS là một điểm tiên lượng mạnh mẽ xác định 4 nhóm rủi ro cho sự sống sót và sự tiến triển thành AML, đã được phát triển và xác thực trong loạt CMML lớn nhất cho đến nay.

Từ khóa


Tài liệu tham khảo

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