Determination of maternal serum acetylcholinesterase in pregnancies with fetal neural tube defects

Prenatal Diagnosis - Tập 7 Số 2 - Trang 75-79 - 1987
Keld E. Sørensen1, Urs Brodbeck1, Anne Gitte Loft2, Hideo Kanaide2
1Institute for Biochemistry and Molecular Biology, University of Bern, Bühlstrasse 28, CH-3000 Bern 9, Switzerland
2Statens Seruminstitut, Amager Boulevard 80, DK‐2300 Copenhagen S, Denmark

Tóm tắt

AbstractWe have investigated the occurrence of acetylcholinesterase (AChE) (E.C.3.1.1.7) in fetal serum, amniotic fluid and maternal serum using an immuno‐chemical assay‐technique employing both polyclonal and monoclonal antibodies. Fetal serum had increased amounts of AChE, which is due to an increase in the 10.5S form of the enzyme. This form was also found in amniotic fluids of pregnancies with a fetal neural tube defect (NTD), but not in normal amniotic fluid. The increase in amniotic fluid AChE was however, not reflected in the maternal serum.

Từ khóa


Tài liệu tham khảo

Brodbeck U., 1986, Progress in Protein‐Lipid Interactions, 303

10.1016/0006-2952(61)90145-9

10.1073/pnas.79.4.1078

10.3109/00365518409083635

Harboe N. Ingild A.(1973). Immunization isolation of immunoglobulins estimation of antibody‐titre Scand. J. Immunol. 2 Suppl. 161–164.

Norgaard‐Pedersen B.(1976) Human alpha‐fetoprotein. A review of recent methodological and clinical studies Scand. J. Immunol. Suppl 4 1–45.

10.1111/j.1471-4159.1982.tb11496.x

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Prenatal Diagnosis

Tập 7 Số 2

75-79

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