Detection of Chromosomal Alterations in the Circulation of Cancer Patients with Whole-Genome Sequencing

American Association for the Advancement of Science (AAAS) - Tập 4 Số 162 - 2012
Rebecca J. Leary1, Mark Sausen1, Isaac Kinde1, Nickolas Papadopoulos1, John D. Carpten2, David W. Craig2, Joyce O’Shaughnessy3, Kenneth W. Kinzler1, Giovanni Parmigiani4,5, Bert Vogelstein1, Luis A. Díaz1, Victor E. Velculescu1
1Ludwig Center for Cancer Genetics and Howard Hughes Medical Institutions, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21287, USA.
2Translational Genomics Research Institute, Phoenix, AZ 85044, USA.
3Baylor Sammons Cancer Center, Texas Oncology, US Oncology, Dallas, TX 75246, USA.
4Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA
5Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA

Tóm tắt

Massively parallel sequencing directly detects tumor-derived chromosomal alterations in plasma DNA from cancer patients.

Từ khóa


Tài liệu tham khảo

10.1038/nrc2091

10.1038/ng.128

10.1038/nature08645

10.1038/25292

10.1073/pnas.202610899

10.1126/scitranslmed.3000702

10.1038/nature08822

10.1073/pnas.0808319105

10.1073/pnas.0810641105

10.1200/JCO.2008.20.1533

10.1200/JCO.1989.7.3.338

10.1038/sj.leu.2404535

10.1097/00062752-199911000-00009

10.1182/blood-2006-01-0092

10.18632/oncotarget.235

10.1002/gcc.20815

10.1073/pnas.0507904102

10.1038/nm.1789

10.1126/scitranslmed.3003726

10.1126/science.2649981

10.1126/science.1651562

10.1126/science.1651563

10.1038/ng.437

10.1371/journal.pone.0010439

10.1073/pnas.0808041105

10.1038/nature09534

10.1038/nature09708

10.1186/gb-2010-11-5-207

10.3322/caac.20138

10.1038/ng.2270

10.1038/ng.2271

10.1007/s00277-002-0427-x

10.1158/2159-8290.CD-11-0194

10.1101/gr.229202

10.1038/ng1416

10.1016/j.cell.2012.04.023

10.1016/0165-4608(86)90377-8

Sauter G., Maeda T., Waldman F. M., Davis R. L., Feuerstein B. G., Patterns of epidermal growth factor receptor amplification in malignant gliomas. Am. J. Pathol. 148, 1047–1053 (1996).

10.1101/gr.5402306

R Development Core Team R: A Language and Environment for Statistical Computing (R Foundation for Statistical Computing Vienna Austria 2008); http://www.R-project.org.

10.1073/pnas.96.16.9236

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American Association for the Advancement of Science (AAAS)

Tập 4 Số 162

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