Detection and Quantitative Evaluation of Lupus Circulating Anticoagulant Activity

Thrombosis and Haemostasis - Tập 57 Số 02 - Trang 144-147 - 1987
Esther Rosner1, Rachel Pauzner1, Ayala Lusky2, Michaela Modan2, Amira Many1
1The Institute of Hematology, the Chaim Sheba Medical Center, Tel-Hashomer and Sackler School of Medicine, Tel-Aviv University, Israel
2The Department of Epidemiology, the Chaim Sheba Medical Center, Tel-Hashomer and Sackler School of Medicine, Tel-Aviv University, Israel

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SummarySixty-six SLE patients were studied for the presence of lupus type circulating anticoagulant. Forty-nine percent of them showed activity of this anticoagulant. The sensitivity of various coagulation tests was compared. Recalcification time was found to be the most sensitive screening test and the kaolin clotting time mixture test, the best for determining the presence of the anticoagulant.Tissue thromboplastin inhibition test detected only half of the patients in whom the anticoagulant was found by recalcification time and kaolin clotting time mixture test.APTT, using 2 different reagents, resulted in 73% and 52% false negatives. A numerical index for determining the presence of the anticoagulant and its quantitative evaluation is suggested.The association between thromboembolic events, recurrent abortions and the different coagulation tests is shown.

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Thrombosis and Haemostasis

Tập 57 Số 02

144-147

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