Detecting multiple spatial disease clusters: information criterion and scan statistic approach

Springer Science and Business Media LLC - Tập 19 - Trang 1-11 - 2020
Kunihiko Takahashi1, Hideyasu Shimadzu2
1Department of Biostatistics M&D Data Science Center, Tokyo Medical and Dental University, Tokyo, Japan
2Teikyo University Graduate School of Public Health, Tokyo, Japan

Tóm tắt

Detecting the geographical tendency for the presence of a disease or incident is, particularly at an early stage, a key challenge for preventing severe consequences. Given recent rapid advancements in information technologies, it is required a comprehensive framework that enables simultaneous detection of multiple spatial clusters, whether disease cases are randomly scattered or clustered around specific epicenters on a larger scale. We develop a new methodology that detects multiple spatial disease clusters and evaluates its performance compared to existing other methods. A novel framework for spatial multiple-cluster detection is developed. The framework directly stands on the integrated bases of scan statistics and generalized linear models, adopting a new information criterion that selects the appropriate number of disease clusters. We evaluated the proposed approach using a real dataset, the hospital admission for chronic obstructive pulmonary disease (COPD) in England, and simulated data, whether the approach tends to select the correct number of clusters. A case study and simulation studies conducted both confirmed that the proposed method performed better compared to conventional cluster detection procedures, in terms of higher sensitivity. We proposed a new statistical framework that simultaneously detects and evaluates multiple disease clusters in a large study space, with high detection power compared to conventional approaches.

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