Design of an Automated Enhanced-Throughput Platform for Functional Characterization of Positive Allosteric Modulator-Induced Leftward Shifts in Apparent Agonist Potency In Vitro
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Hall, 2000, Modeling the Functional Effects of Allosteric Modulators at Pharmacological Receptors: An Extension of the Two-State Model of Receptor Activation, Mol. Pharmacol, 58, 1412, 10.1124/mol.58.6.1412
Christopoulos, 2002, Allosteric Binding Sites on Cell-Surface Receptors: Novel Targets for Drug Discovery, Nat. Rev. Drug Discov, 1, 198, 10.1038/nrd746
May, 2007, Allosteric Modulation of G-Protein Coupled Receptors, Annu. Rev. Pharmacol. Toxicol, 47, 1, 10.1146/annurev.pharmtox.47.120505.105159
Bridges, 2008, G-Protein-Coupled Receptors: From Classical Modes of Modulation to Allosteric Mechanisms, ACS Chem. Biol, 3, 530, 10.1021/cb800116f
Christopoulos, 2002, G-Protein Coupled Receptor Allosterism and Complexing, Pharmacol. Rev, 54, 323, 10.1124/pr.54.2.323
Möhler, 2002, A New Benzodiazepine Pharmacology, J. Pharmacol. Exp. Ther, 300, 2, 10.1124/jpet.300.1.2
Mirza, 2010, The Role of GABA(A) Receptor Subtypes as Analgesic Targets, Drug News Perspect, 23, 351, 10.1358/dnp.2010.23.6.1489909
Marino, 2003, Direct and Indirect Modulation of the N-methyl D-aspartate Receptor, Curr. Drug Targets CNS Neurol. Disord, 1, 1, 10.2174/1568007023339544
Capelli, 2010, Identification of Novel alpha7 nAChR Positive Allosteric Modulators with the use of Pharmacophore In Silico Screening Methods, Bioorg. Med. Chem. Lett, 20, 4561, 10.1016/j.bmcl.2010.06.014
Johnson, 2003, Discovery of Allosteric Potentiators for the Metabotropic Glutamate 2 Receptor: Synthesis and Subtype Selectivity of N-(4-(2-methoxyphenoxy)phenyl)-N-(2,2,2-trifluoroethylsulfonyl)pyrid-3-ylmethylamine, J. Med. Chem, 46, 3189, 10.1021/jm034015u
Valenti, 2003, Modulation of Excitatory Transmission onto Midbrain Dopaminergic Neurons of the Rat by Activation of Group III Metabotropic Glutamate Receptors, Ann. N. Y. Acad. Sci, 1003, 479, 10.1196/annals.1300.058
Hemstapat, 2006, A Novel Class of Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 1 Interact with a Site Distinct from That of Negative Allosteric Modulators, Mol. Pharmacol, 70, 616, 10.1124/mol.105.021857
Sheffler, 2008, Allosteric Potentiators of Metabotropic Glutamate Receptor Subtype 1a Differentially Modulate Independent Signaling Pathways in Baby Hamster Kidney Cells, Neuropharmacology, 55, 419, 10.1016/j.neuropharm.2008.06.047
Valant, 2010, Delineating the Mode of Action of Adenosine A1 Receptor Allosteric Modulators, Mol. Pharmacol, 78, 444, 10.1124/mol.110.064568
Thomas, 2008, G Protein Coupling and Signaling Pathway Activation by M1 Muscarinic Acetylcholine Receptor Orthosteric and Allosteric Agonists, J. Pharmacol. Exp. Ther, 327, 365, 10.1124/jpet.108.141788
Yang, 2010, Parallel Synthesis of N-biaryl Quinolone Carboxylic Acids as Selective M(1) Positive Allosteric Modulators, Bioorg. Med. Chem. Lett, 20, 531, 10.1016/j.bmcl.2009.11.100
Leach, 2010, Molecular Mechanisms of Action and In Vivo Validation of an M4 Muscarinic Acetylcholine Receptor Allosteric Modulator with Potential Antipsychotic Properties, Neuropsychopharmacology, 35, 855, 10.1038/npp.2009.194
Gjoni, 2006, The Positive Allosteric Modulator GS39783 Enhances GABA(B) Receptor-Mediated Inhibition of Cyclic AMP Formation in Rat Striatum In Vivo, J. Neurochem, 96, 1416, 10.1111/j.1471-4159.2006.03660.x
Pin, 2007, Allosteric Modulators of GABA(B) Receptors: Mechanism of Action and Therapeutic Perspective, Curr. Neuropharmacol, 5, 195, 10.2174/157015907781695919
Ray, 2005, Calindol, a Positive Allosteric Modulator of the Human Ca(2+) Receptor, Activates an Extracellular Ligand-Binding Domain-Deleted Rhodopsin-Like Seven-Transmembrane Structure in the Absence of Ca(2+), J. Biol. Chem, 280, 37013, 10.1074/jbc.M506681200
Harrington, 2007, Calcium Sensing Receptor Activators: Calcimimetics, Curr. Med. Chem, 14, 3027, 10.2174/092986707782794096
Jensen, 2007, Allosteric Modulation of the Calcium-Sensing Receptor, Curr. Neuropharmacol, 5, 180, 10.2174/157015907781695982
Kennedy, 2008, Application of Combinatorial Science on Modern Drug Discovery, J. Comb. Chem, 10, 345, 10.1021/cc700187t
Schwartz, 2007, Allosteric Enhancers, Allosteric Agonists, and Ago-Allosteric Modulators: Where Do They Bind and How Do They Act?, Trends Pharmacol. Sci, 28, 366, 10.1016/j.tips.2007.06.008
O’Brien, 2003, A Family of Highly Selective Allosteric Modulators of the Metabotropic Glutamate Receptor Subtype 5, Mol. Pharmacol, 64, 731, 10.1124/mol.64.3.731
Sharma, 2008, Synthesis and SAR of a mGluR5 Allosteric Partial Antagonist Lead: Unexpected Modulation of Pharmacology with Slight Structural Modifications to a 5-(Phenylethynyl)pyrimidine Scaffold, Bioorg. Med. Chem. Lett, 18, 4098, 10.1016/j.bmcl.2008.05.091
Lindsley, 2004, Discovery of Positive Allosteric Modulators for the Metabotropic Glutamate Receptor Subtype 5 from a Series of N-(1,3-diphenyl-1H-pyrazol-5yl)benzamides That Potentiate Receptor Function In Vivo, J. Med. Chem, 47, 5825, 10.1021/jm049400d