Design and implementation of GRIP: a computerized glucose control system at a surgical intensive care unit

BMC Medical Informatics and Decision Making - Tập 5 - Trang 1-10 - 2005
Mathijs Vogelzang1,2, Felix Zijlstra2, Maarten WN Nijsten1
1Surgical Intensive Care Unit, Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
2Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

Tóm tắt

Tight glucose control by intensive insulin therapy has become a key part of critical care and is an important field of study in acute coronary care. A balance has to be found between frequency of measurements and the risk of hypoglycemia. Current nurse-driven protocols are paper-based and, therefore, rely on simple rules. For safety and efficiency a computer decision support system that employs complex logic may be superior to paper protocols. We designed and implemented GRIP, a stand-alone Java computer program. Our implementation of GRIP will be released as free software. Blood glucose values measured by a point-of-care analyzer were automatically retrieved from the central laboratory database. Additional clinical information was asked from the nurse and the program subsequently advised a new insulin pump rate and glucose sampling interval. Implementation of the computer program was uneventful and successful. GRIP treated 179 patients for a total of 957 patient-days. Severe hypoglycemia (< 2.2 mmol/L) only occurred once due to human error. With a median (IQR) of 4.9 (4.2 – 6.2) glucose measurements per day the median percentage of time in which glucose fell in the target range was 78%. Nurses rated the program as easy to work with and as an improvement over the preceding paper protocol. They reported no increase in time spent on glucose control. A computer driven protocol is a safe and effective means of glucose control at a surgical ICU. Future improvements in the recommendation algorithm may further improve safety and efficiency.

Tài liệu tham khảo

Mizock BA: Alterations in fuel metabolism in critical illness: hyperglycaemia. Best Pract Res Clin Endocrinol Metab. 2001, 15 (4): 533-551. 10.1053/beem.2001.0168.

Umpierrez GE, Isaacs SD, Bazargan N, You X, Thaler LM, Kitabchi AE: Hyperglycemia: an independent marker of in-hospital mortality in patients with undiagnosed diabetes. J Clin Endocrinol Metab. 2002, 87 (3): 978-982. 10.1210/jc.87.3.978.

Capes SE, Hunt D, Malmberg K, Gerstein HC: Stress hyperglycaemia and increased risk of death after myocardial infarction in patients with and without diabetes: a systematic overview. Lancet. 2000, 355 (9206): 773-778. 10.1016/S0140-6736(99)08415-9.

Capes SE, Hunt D, Malmberg K, Pathak P, Gerstein HC: Stress hyperglycemia and prognosis of stroke in nondiabetic and diabetic patients: a systematic overview. Stroke. 2001, 32 (10): 2426-2432.

van den Berghe G, Wouters P, Weekers F, Verwaest C, Bruyninckx F, Schetz M, Vlasselaers D, Ferdinande P, Lauwers P, Bouillon R: Intensive insulin therapy in critically ill patients. N Engl J Med. 2001, 345 (19): 1359-1367. 10.1056/NEJMoa011300.

Dellinger RP, Carlet JM, Masur H, Gerlach H, Calandra T, Cohen J, Gea-Banacloche J, Keh D, Marshall JC, Parker MM, Ramsay G, Zimmerman JL, Vincent JL, Levy MM, Surviving Sepsis Campaign Management Guidelines Committee: Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Crit Care Med. 2004, 32 (3): 858-873. 10.1097/01.CCM.0000117317.18092.E4.

Brown G, Dodek P: Intravenous insulin nomogram improves blood glucose control in the critically ill. Crit Care Med. 2001, 29 (9): 1714-1719. 10.1097/00003246-200109000-00010.

Chant C, Wilson G, Friedrich JO: Validation of an insulin infusion nomogram for intensive glucose control in critically ill patients. Pharmacotherapy. 2005, 25 (3): 352-359. 10.1592/phco.25.3.352.61594.

van der Horst IC, Zijlstra F, van't Hof AW, Doggen CJ, de Boer MJ, Suryapranata H, Hoorntje JC, Dambrink JH, Gans RO, Bilo HJ, Zwolle Infarct Study Group: Glucose-insulin-potassium infusion in patients treated with primary angioplasty for acute myocardial infarction: the glucose-insulin-potassium study: a randomized trial. J Am Coll Cardiol. 2003, 42 (5): 784-791. 10.1016/S0735-1097(03)00830-1.

Mehta SR, Yusuf S, Díaz R, Zhu J, Pais P, Xavier D, Paolasso E, Ahmed R, Xie C, Kazmi K, Tai J, Orlandini A, Pogue J, Liu L, CREATE-ECLA Trial Group Investigators: Effect of glucose-insulin-potassium infusion on mortality in patients with acute ST-segment elevation myocardial infarction: the CREATE-ECLA randomized controlled trial. JAMA. 2005, 293 (4): 437-446. 10.1001/jama.293.14.1746.

Malmberg K, Rydén L, Wedel H, Birkeland K, Bootsma A, Dickstein K, Efendic S, Fisher M, Hamsten A, Herlitz J, Hildebrandt P, MacLeod K, Laakso M, Torp-Pedersen C, Waldenström A, DIGAMI 2 Investigators : Intense metabolic control by means of insulin in patients with diabetes mellitus and acute myocardial infarction (DIGAMI 2): effects on mortality and morbidity. Eur Heart J. 2005, 26 (7): 650-661. 10.1093/eurheartj/ehi199.

Finney SJ, Zekveld C, Elia A, Evans TW: Glucose control and mortality in critically ill patients. JAMA. 2003, 290 (15): 2041-2047. 10.1001/jama.290.15.2041.

van den Berghe G, Bouillon R: Optimal control of glycemia among critically ill patients. JAMA. 2004, 291 (10): 1198-1199. 10.1001/jama.291.10.1198-b.

Chase JG, Shaw GM, Lin J, Doran CV, Hann C, Lotz T, Wake GC, Broughton B: Targeted glycemic reduction in critical care using closed-loop control. Diabetes Technol Ther. 2005, 7 (2): 274-282. 10.1089/dia.2005.7.274.

Free Software Foundation: GNU General Public License. [http://www.gnu.org/licenses/gpl.html]

Chee F, Fernando TL, Savkin AV, van Heeden V: Expert PID control system for blood glucose control in critically ill patients. IEEE Trans Inf Technol Biomed. 2003, 7 (4): 419-425. 10.1109/TITB.2003.821326.

Goldberg PA, Siegel MD, Russell RR, Sherwin RS, Halickman JI, Cooper DA, Dziura JD, Inzucchi SE: Experience with the continuous glucose monitoring system in a medical intensive care unit. Diabetes Technol Ther. 2004, 6 (3): 339-347. 10.1089/152091504774198034.

Hann CE, Chase JG, Lin J, Lotz T, Doran CV, Shaw GM: Integral-based parameter identification for long-term dynamic verification of a glucose-insulin system model. Comput Methods Programs Biomed. 2005, 77 (3): 259-270. 10.1016/j.cmpb.2004.10.006.

Rood E, Bosman RJ, van der Spoel JI, Taylor P, Zandstra DF: Use of a computerized guideline for glucose regulation in the intensive care unit improved both guideline adherence and glucose regulation. J Am Med Inform Assoc. 2005, 12 (2): 172-180. 10.1197/jamia.M1598.

The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1472-6947/5/38/prepub