Design and Physicochemical Characterization of Lysozyme Loaded Niosomal Formulations as a New Controlled Delivery System

Pharmaceutical Chemistry Journal - Tập 53 - Trang 921-930 - 2020
Somayeh Sadeghi1,2, Parastoo Ehsani2, Reza Ahangari Cohan1, Soroush Sardari3, Iman Akbarzadeh1,4, Haleh Bakhshandeh1, Dariush Norouzian1
1Department of Nano Biotechnology, New Technology Research Group, Pasteur Institute of Iran, Tehran, Iran
2Department of Molecular biology, Pasteur Institute of Iran, Tehran, Iran
3Department of Medical Biotechnology, Biotechnology Research Centre, Pasteur Institute of Iran, Tehran, Iran
4Department of Chemical and Petroleum Engineering, Biotechnology Research Centre, Sharif University of Technology, Tehran, Iran

Tóm tắt

Lysozyme loaded niosomes containing various molar ratios of two kinds of surfactants were prepared and the properties of these niosomal formulations were studied. The results revealed that the size of niosomes varied between 240.06 ± 32.41 and 895.2 ± 20.84 nm. Formulations with the lowest size and no precipitation had entrapment efficiencies ranging from 60.644 ± 3.310 to 66.333 ± 1.98%. Their controlled release profiles after 48 h were 15.67, 20.67 and 31.50%. After 2 months, the most stable formulation in terms of size, PDI, zeta potential, and entrapment efficiency was used to study the secondary structures of lysozyme in niosomal and free forms. Lysozyme loaded niosome and lysozyme adsorbed on the surface of niosome fell into one category in terms of the formation of α-helix,β -sheet, and turn structures. This study suggests that niosomes could be a promising delivery system for lysozyme with prolonged release profiles, which can be used in pharmaceutical and food industries.

Tài liệu tham khảo

J. Manosroi, W. Lohcharoenkal, F. Gotz, et al., J. Pharm. Sci., 100, 1525 (2011).

S. Moghassemi, A. Hadjizadeh, A. Hakamivala, and K. Omidfar, AAPS PharmSciTech, 18, 34 (2017).

V. Akbari, D. Abedi, A. Pardakhty, and H. Sadeghi-Aliabadi, Avicenna J. Med. Biotechnol., 7, 69 (2015).

A. Manosroi, P. Khanrin, R. G. Werner, et al., J. Microencaps., 27, 272 (2010).

A. Pardakhty, J. Varshosaz, and A. Rouholamini, Int. J. Pharm. (Amsterdam, Neth.), 328, 130 (2007).

L. Tavano, R. Muzzalupo, L. Mauro, et al., Langmuir, 29, 12638 (2013).

C.-O. Rentel, J. Bouwstra, B. Naisbett, and H. Junginger, Int. J. Pharm. (Amsterdam, Neth.), 186, 161 (1999).

S. M. Niemiec, C. Ramachandran, and N. Weiner, Pharm. Res., 12, 1184 (1995).

A. Manosroi, W. Lohcharoenkal, F. Gotz, et al., J. Biomed. Nanotechnol., 7, 366 (2011).

J. Brewer and J. Alexander, Immunology, 75, 570 (1992).

S. Murdan, G. Gregoriadis, and A. T. Florence, Eur. J. Pharm. Sci., 8, 177 (1999).

S.-I. Park and S. M. Yoe, Animal Cells Systems, 16, 455 (2012).

L. Callewaert and C. W. Michiels, J. Biosci., 35, 127 (2010).

O. S. A. Abed, C. Chaw, L. Williams, and A. A. Elkordy, Sci. Rep., 8, 13158 (2018).

H. Yoshida, C.-M. Lehr, W. Kok, et al., J. Control. Release, 21, 145 (1992).

R. Rochdy Haj-Ahmad, A. Ali Elkordy, and C. Shu Chaw, Curr. Drug Deliv., 12, 628 (2015).

The HLB System: a Time-Saving Guide to Emulsifier Selection, ICI Americas Inc. (1984).

V. B. Junyaprasert, P. Singhsa, J. Suksiriworapong, and D. Chantasart, Int. J. Pharm. (Amsterdam, Neth.), 423, 303 (2012).

N. Bharti, S. Loona, and M. Khan, Int. J. Pharm. Sci. Rev. Res., 12, 67 (2012).

S. Taymouri and J. Varshosaz, Adv. Biomed. Res., 5, 48 (2016).

M. Hope, M. Bally, L. Mayer, et al., Chem. Phys. Lipids, 40, 89 (2016).

M. M. El-Sayed, A. K. Hussein, H. A. Sarhan, and H. F. Mansour, Drug Dev. Ind. Pharm., 43, 902 (2017).

N. J. Kruger, The Bradford method for protein quantitation, in: The Protein Protocols Handbook, Springer (2002), p. 15.

D. Charnvanich, N. Vardhanabhuti, and P. Kulvanich, AAPS PharmSciTech, 11, 832 (2010).

A. Manosroi, P. Wongtrakul, J. Manosroi, et al., Colloids Surf. B, 30, 129 (2003).

C. Bernsdorff, A. Wolf, R. Winter, and E. Gratton, Biophys. J., 72, 1264 (1997).

P. Balakrishnan, S. Shanmugam,W. S. Lee, et al., Int. J. Pharm. (Amsterdam, Neth.), 377, 1 (2009).

C. S. Chaw and K. Y. Ah Kim, Pharmaceutical development and technology 2013, 18, 667.

T. Yoshioka, B. Sternberg, and A. T. Florence, Int. J. Pharm. (Amsterdam, Neth.),105, 1 (1994).

S. Moghassemi, E. Parnian, A. Hakamivala, et al., Mater. Sci. Eng. C, 46, 333 (2015).

A. Y. Waddad, S. Abbad, F. Yu, et al., Int. J. Pharm. (Amsterdam, Neth.), 456, 446 (2013).

S. McLaughlin, G. Szabo, and G. Eisenman, J. Gen. Pphysiol., 58, 667 (1971).

A. Manosroi and K. Bauer, Drug Dev. Ind. Pharm., 15, 2531 (1989).

M. Raslan, J. Life Med., 1, 15 (2013).

M. Mokhtar, O. A. Sammour, M. A. Hammad, and N. A. Megrab, Int. J. Pharm. (Amsterdam, Neth.)., 361, 104 (2008).

J. Varshosaz, A. Pardakhty, V.-I. Hajhashemi, and A. R. Najafabadi, Drug Deliv., 10, 251 (2003).

H. S. Barakat, I. A. Darwish, L. K. El-Khordagui, and N. M. Khalafallah, Drug Dev. Ind. Pharm., 35, 631 (2009).

A. L. Weiner, Adv. Drug Deliv. Rev., 3, 307 (1989).

K. Ruckmani and V. Sankar, AAPS PharmSciTech, 11, 1119 (2010).

S. Dash, P. N. Murthy, L. Nath, and P. Chowdhury, Acta Pol. Pharm., 67, 217 (2010).

S. Kamboj, V. Saini, and S. Bala, Sci. World J., 2014, 1 (2014).

I. F. Uchegbu and S. P. Vyas, Int. J. Pharm. (Amsterdam, Neth.)., 172, 33 (1998).

A. Balasubramaniam, V. Anil Kumar, and K. Sadasivan Pillai, Drug Dev. Ind. Ppharm., 28, 1181 (2002).

M. Lawrence, S. Chauhan, S. Lawrence, and D. Barlow, STP Pharma Sci., 6, 49 (1996).

M. Seras-Cansell, M. Ollivon, and S. Lesieur, STP Pharma Sci., 6, 12 (1996).

E. Moazeni, K. Gilani, F. Sotoudegan, A. Pardakhty, et al., J. Microencaps., 27, 618 (2010).

A. Pardakhty, E. Moazeni, J. Varshosaz, et al., DARU J. Pharm. Sci., 19, 404 (2011).

Thông tin
Thông tin xuất bản

Pharmaceutical Chemistry Journal

Tập 53

921-930

Thông tin tác giả