Design, Synthesis, and Biological Evaluation of Levoglucosenone‐Derived Ras Activation Inhibitors

ChemMedChem - Tập 4 Số 4 - Trang 524-528 - 2009
Christian Müller1, María Antonia Gómez-Zurita Frau1, Dario Ballinari1, Sonia Colombo2, Alessandro Bitto2, Enzo Martegani2, Cristina Airoldi2, Anske Stephanie van Neuren3, Matthias Stein3, Jörg Weiser3, C Battistini1, Francesco Peri2
1B. U. Oncology, Nerviano Medical Sciences, Viale Pasteur 10, 20014 Nerviano, MI (Italy), Fax: (+39) 03-3158-1347
2Department of Biotechnology and Biosciences, University of Milan‐Bicocca, Piazza della Scienza 2, 20126 Milan (Italy), Fax: (+39) 02‐6448‐3565
3Anterio Consulting & Research GmbH, Augustaanlage 23, 68165 Mannheim (Germany)

Tóm tắt

AbstractA panel of new potential Ras ligands was generated by decorating a tricyclic levoglucosenone‐derived scaffold with aromatic moieties. Some members of the panel show in vitro inhibitory activity toward the nucleotide exchange process on Ras and are toxic to some human cancer cell lines.magnified image

Từ khóa


Tài liệu tham khảo

 

10.1146/annurev.bi.56.070187.004023

10.1146/annurev.bi.62.070193.004223

10.1074/jbc.273.32.19925

 

10.1016/0092-8674(89)90976-8

10.1038/341209a0

 

10.1002/1521-3757(20001201)112:23<4360::AID-ANGE4360>3.0.CO;2-J

10.1002/1521-3773(20001201)39:23<4192::AID-ANIE4192>3.0.CO;2-Y

10.1038/nrc969

10.1016/j.cell.2007.05.018

 

10.1016/S0921-4410(04)22006-3

10.1016/S1367-5931(97)80010-5

 

10.1111/j.1432-1033.1997.00330.x

10.1016/S0014-5793(98)00930-2

10.1073/pnas.96.12.7065

 

10.1002/ange.200352587

10.1002/anie.200352587

10.1002/ange.200353089

10.1002/anie.200353089

 

10.1016/S0968-0896(96)00202-7

10.1021/bi9805691

 

10.1196/annals.1329.007

10.1002/cbic.200400420

10.1002/ejoc.200600132

10.1002/cbic.200700185

1994, Levoglucosenone and Levoglucosans, Chemistry and Application

Paton R. M., 1994, Levoglucosenone and Levoglucosans, Chemistry and Application, 38

10.1039/c39880000440

10.1016/S0040-4020(01)80476-2

Chanet‐Ray J., 1994, Levoglucosenone and Levoglucosans, Chemistry and Application, 91

 

10.1039/b007164l

10.1055/s-2001-16042

10.1016/S0076-6879(95)55012-7

10.1038/nrc1300

Thông tin
Thông tin xuất bản

ChemMedChem

Tập 4 Số 4

524-528

Thông tin tác giả