Depressive symptoms and cardiovascular disease: a population-based study of older adults in rural Burkina Faso

BMJ Open - Tập 10 Số 12 - Trang e038199 - 2020
Ben Brinkmann1, Collin Payne2, Iliana V. Kohler3, Guy Harling4,5,6,7, Justin E. Davies8, Miles D. Witham9,10, Mark J. Siedner11, Ali Sié12, Mamadou Bountogo12, Lucienne Ouermi12, Boubacar Coulibaly12, Till Bärnighausen4,1
1Heidelberg Institute of Global Health, Heidelberg University, Heidelberg, Germany
2School of Demography, The Australian National University, Canberra, Australian Capital Territory, Australia
3Population Studies Center (PSC) and Department of Sociology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
4Africa Health Research Institute, KwaZulu-Natal, South Africa
5Harvard Center for Population and Development Studies, Harvard T.H. Chan School of Public Health, Cambridge, Massachusetts, USA
6Institute for Global Health, University College London, London, UK
7MRC/Wits Rural Public Health & Health Transitions Research Unit (Agincourt), University of the Witwatersrand, Johannesburg, South Africa
8Institute of Applied Health Research, University of Birmingham, Birmingham, UK
9AGE Research Group, NIHR Newcastle Biomedical Research Centre, Newcastle University, Newcastle upon Tyne, UK
10Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
11Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
12Centre de Recherche en Sante de Nouna, Nouna, Boucle du Mouhoun, Burkina Faso

Tóm tắt

ObjectivesTo contribute to the current understanding of depressive disorders in sub-Saharan African (SSA) countries by examining the association of depressive symptoms with cardiovascular and cardiometabolic conditions in a population-based study of middle-aged and older adults in rural Burkina Faso.SettingThis study was conducted in the Nouna Health and Demographic Surveillance System in north-western Burkina Faso, in a mixed rural and small-town environment. The data were obtained between May and July 2018.ParticipantsConsenting adults over 40 years of age (n=3026).Primary and secondary outcome measuresDepressive symptoms were assessed using the Patient Health Questionnaire depression module (PHQ-9). Chronic cardiometabolic conditions were assessed via a lipid panel and glycated haemoglobin measures from serum, alongside anthropometry and blood pressure measurements and a self-reported questionnaire. Multivariable linear regression was used to test the relationship between depressive symptoms and cardiovascular/cardiometabolic conditions after controlling for sociodemographic factors.ResultsDepressive symptoms were not associated with the metabolic syndrome (standardised beta coefficient=0.00 (95% CI −0.04 to 0.03)), hypertension (beta=0.01 (95% CI −0.02 to 0.05)), diabetes mellitus (beta=0.00 (95% CI −0.04 to 0.04)) and past diagnosis of elevated blood pressure or blood sugar. Prior stroke diagnosis (beta=0.04 (95% CI 0.01 to 0.07)) or heart disease (beta=0.08 (95% CI 0.05 to 0.11)) was positively associated with the standardised PHQ-9 score as were self-reported stroke symptoms.ConclusionObjectively measured cardiometabolic conditions had no significant association with depressive symptoms in an older, poor, rural SSA population, in contrast to observations in high income countries. However, consequences of cardiovascular disease such as stroke and heart attack were associated with depressive symptoms in older adults in Burkina Faso.

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BMJ Open

Tập 10 Số 12

e038199

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