Cấy ghép răng trong bệnh nhân suy giảm miễn dịch: đánh giá hệ thống và phân tích tổng hợp

Fabian Duttenhoefer1, Marc Anton Fuessinger1, Yasmin Beckmann1, Rainer Schmelzeisen1, Knut A. Groetz2, Martin Boeker3
1Department of Oral and Craniomaxillofacial Surgery, University Hospital Freiburg, Hugstetter Str. 55, 79106, Freiburg, Germany
2Department of Oral and Maxillofacial Surgery, HELIOS Dr. Horst-Schmidt-Kliniken, Academic Teaching Hospital University Mainz, Ludwig-Erhard-Str. 100, 65199, Wiesbaden, Germany
3Institute of Medical Biometry and Statistics, Medical Data Science, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany

Tóm tắt

Tóm tắt Mục tiêu Các tình trạng sức khỏe suy giảm và sự thiếu hụt khả năng hồi phục của cơ thể là những yếu tố quan trọng nhất dẫn đến thất bại trong cấy ghép răng. Hiện nay, các bác sĩ lâm sàng đang phải đối mặt với số lượng ngày càng tăng bệnh nhân suy giảm miễn dịch yêu cầu phục hồi chức năng dựa trên cấy ghép. Để cung cấp bằng chứng lâm sàng cho việc ra quyết định trong tương lai, mục tiêu của đánh giá hệ thống và phân tích tổng hợp này là phân tích ảnh hưởng của suy giảm miễn dịch đối với sự sống sót của cấy ghép răng.

Từ khóa


Tài liệu tham khảo

Vogel R, Smith-Palmer J, Valentine W. Evaluating the health economic implications and cost-effectiveness of dental implants: a literature review. Int J Oral Maxillofac Implants. 2013;28(2):343–56.

Esposito M, Thomsen P, Ericson LE, Lekholm U. Histopathologic observations on early oral implant failures. Int J Oral Maxillofac Implants. 1999;14(6):798–810.

Porter JA, von Fraunhofer JA. Success or failure of dental implants? A literature review with treatment considerations. Gen Dent. 2005;53(6):423–32 quiz433–446.

Hwang D, Wang H-L. Medical contraindications to implant therapy: part I: absolute contraindications. Implant Dent. 2006;15(4):353–360. Implant Dentistry.

Kawai T, Akira S. Innate immune recognition of viral infection. Nat Immunol. 2006;7(2):131–137. Nature Publishing Group

Midwood KS, Williams LV, Schwarzbauer JE. Tissue repair and the dynamics of the extracellular matrix. Int J Biochem Cell Biol. 2004;36(6):1031–7.

Albrektsson T, Brånemark PI, Hansson HA, Lindström J. Osseointegrated titanium implants. Requirements for ensuring a long-lasting, direct bone-to-implant anchorage in man. Acta Orthop Scand. 1981;52(2):155–70.

Colnot C, Romero DM, Huang S, Rahman J, Currey JA, Nanci A, et al. Molecular analysis of healing at a bone-implant interface. J Dent Res. 2007;86(9):862–7.

Harpaz R, Dahl RM, Dooling KL. Prevalence of immunosuppression among US adults, 2013. JAMA. 2016;316(23):2547.

Jacobson DL, Gange SJ, Rose NR, Graham NM. Epidemiology and estimated population burden of selected autoimmune diseases in the United States. Clin Immunol Immunopathol. 1997;84(3):223–43.

Lerner A, Jeremias P, Matthias T. The world incidence and prevalence of autoimmune diseases is increasing. Int J Celiac Dis. 2016;3(4):151–5.

Mor G, Cardenas I. The immune system in pregnancy: a unique complexity. Am J Reprod Immunol. 2010;63(6):425–433. Blackwell Publishing Ltd.

Pedersen BK, Bruunsgaard H, Jensen M, Toft AD, Hansen H, Ostrowski K. Exercise and the immune system--influence of nutrition and ageing. J Sci Med Sport. 1999;2(3):234–52.

Gavazzi G, Krause K-H. Ageing and infection. Lancet Infect Dis. 2002;2(11):659–66.

Norman DC. Fever in the elderly. Clin Infect Dis. 2000;31(1):148–51.

Holzheimer RG, Mannick JA. Surgical treatment: evidence-based and problem-oriented. Munich: Zuckschwerdt; 2001.

Moher D, Liberati A, Tetzlaff J, Altman DG, The PRISMA Group. Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement. PLoS Med. 2009;6(7):e1000097. Public Library of Science.

Lefebvre C, Manheimer E, Glanville J. Searching for studies. In: Higgins JP, Green S, editors. Cochrane handbook for systematic reviews of interventions. Chichester: Wiley; 2008. p. 95–150.

Higgins JP, Green S. Guide to the contents of a Cochrane protocol and review. In: Higgins JP, Green S, editors. Cochrane handbook for systematic reviews of interventions. Chichester: Wiley; 2008. p. 51–79.

Green S, Higgins JP. Preparing a Cochrane review. In: Higgins JP, Green S, editors. Cochrane handbook for systematic reviews of interventions. Chichester: Wiley; 2008. p. 11–30.

Higgins JPT, Altman DG, Gøtzsche PC, Jüni P, Moher D, Oxman AD, et al. The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. BMJ 2011;343(oct18 2):d5928. British Medical Journal Publishing Group.

Schwarzer G, Carpenter JR, Rücker G. Fixed effect and random effects meta-analysis. Meta-analysis with R. Cham: Springer International Publishing; 2015. 21–53. (Use R!).

2012 RCT, R Foundation for Statistical Computing Vienna, Austria. R: a language and environment for statistical computing. 2nd ed. R Foundation for Statistical Computing Vienna. 2010. Available from: http://www.R-project.org/. Cited 23 Mar 2013.

news GSR, 2007. Meta: an R package for meta-analysis. bioconductorstatistiktu-dortmundde. https://bioconductor.statistik.tu-dortmund.de.

Stevenson GC, Riano PC, Moretti AJ, Nichols CM, Engelmeier RL, Flaitz CM. Short-term success of osseointegrated dental implants in HIV-positive individuals: a prospective study. JCDP. 2007;8(1):1–10.

May MC, Andrews PN, Daher S, Reebye UN. Prospective cohort study of dental implant success rate in patients with AIDS. Int J Implant Dent. 2016;2(1):20.

Gherlone EF, Capparè P, Tecco S, Polizzi E, Pantaleo G, Gastaldi G, et al. A prospective longitudinal study on implant prosthetic rehabilitation in controlled HIV-positive patients with 1-year follow-up: the role of CD4+ level, smoking habits, and oral hygiene. Clin Implant Dent Relat Res. 2015;18(5):955–64.

Gherlone EF, Capparè P, Tecco S, Polizzi E, Pantaleo G, Gastaldi G, et al. Implant prosthetic rehabilitation in controlled HIV-positive patients: a prospective longitudinal study with 1-year follow-up. Clin Implant Dent Relat Res. 2nd ed. 2015;18(4):725–34.

Gastaldi G, Vinci R, Francia MC, Bova F, Capparé P. Immediate fixed rehabilitation supported by axial and tilted implants of edentulous jaws: a prospective longitudinal study in HIV- positive patients. J Osseointegr. 2017;9(2):239–44.

Maló P, de Araújo NM, Gonçalves Y, Lopes A. Long-term outcome of implant rehabilitations in patients with systemic disorders and smoking habits: a retrospective clinical study. Clin Implant Dent Relat Res. 2015;18(4):649–65.

Gay-Escoda C, Perez-Alvarez D, Camps-Font O, Figueiredo R. Long-term outcomes of oral rehabilitation with dental implants in HIV-positive patients: a retrospective case series. Med Oral Patol Oral Cir Bucal. 2016;21(3):e385–91.

Baron M, Gritsch F, Hansy A-M, Haas R. Implants in an HIV-positive patient: a case report. Int J Oral Maxillofac Implants. 2004;19(3):425–30.

Achong RM, Shetty K, Arribas A, Block MS. Implants in HIV-positive patients: 3 case reports. J Oral Maxillofac Surg. 2006;64(8):1199–203.

Kolhatkar S, Khalid S, Rolecki A, Bhola M, Winkler JR. Immediate dental implant placement in HIV-positive patients receiving highly active antiretroviral therapy: a report of two cases and a review of the literature of implants placed in HIV-positive individuals. J Periodontol. 2011;82(3):505–11.

Oliveira MA, Gallottini M, Pallos D, Maluf PSZ, Jablonka F, Ortega KL. The success of endosseous implants in human immunodeficiency virus-positive patients receiving antiretroviral therapy a pilot study. J Am Dent Assoc. 2011;142(9):1010–6.

Castellanos-Cosano L, Núñez-Vázquez R-J, Segura-Egea J-J, Torres-Lagares D, Corcuera-Flores J-R, Machuca-Portillo G. Protocol for oral implant rehabilitation in a hemophilic HIV-positive patient with type C hepatitis. Implant Dent. 2014;23(5):622–5.

Vidal F, Vidal R, Bochnia J, de Souza RC, Gonçalves LS. Dental implants and bone augmentation in HIV-infected patients under HAART: case report and review of the literature. Spec Care Dentist. 2017;37(3):150–5.

Strietzel FP, Rothe S, Reichart PA, Schmidt-Westhausen A-M. Implant-prosthetic treatment in HIV-infected patients receiving highly active antiretroviral therapy: report of cases. Int J Oral Maxillofac Implants. 2006;21(6):951–6.

Alsaadi G, Quirynen M, Komárek A, van Steenberghe D. Impact of local and systemic factors on the incidence of late oral implant loss. Clin Oral Implants Res. 2008;19(7):670–6.

Moy PK, Medina D, Shetty V, Aghaloo TL. Dental implant failure rates and associated risk factors. Int J Oral Maxillofac Implants. 2005;20(4):569–77.

Ihara K, Goto M, Miyahara A, Toyota J, Katsuki T. Multicenter experience with maxillary prostheses supported by Brånemark implants: a clinical report. Int J Oral Maxillofac Implants. 1998;13(4):531–8.

Kovács AF. Influence of chemotherapy on endosteal implant survival and success in oral cancer patients. Int J Oral Maxillofac Surg. 2001;30(2):144–7.

Alsaadi G, Quirynen M, Michiles K, Teughels W, Komárek A, van Steenberghe D. Impact of local and systemic factors on the incidence of failures up to abutment connection with modified surface oral implants. J Clin Periodontol. 2007;0(0):071127132039002.

van Steenberghe D, Jacobs R, Desnyder M, Maffei G, Quirynen M. The relative impact of local and endogenous patient-related factors on implant failure up to the abutment stage. Clin Oral Implants Res. 2002;13(6):617–22.

Steiner M, Windchy A, Gould AR, Kushner GM, Weber R. Effects of chemotherapy in patients with dental implants. J Oral Implantol. 1995;21(2):142–7.

Sager RD, Theis RM. Dental implants placed in a patient with multiple myeloma: report of case. J Am Dent Assoc. 1990;121(6):699–701.

Bencharit S, Reside GJ, Howard-Williams EL. Complex prosthodontic treatment with dental implants for a patient with polymyalgia rheumatica: a clinical report. Int J Oral Maxillofac Implants. 2010;25(6):1241–5.

Chochlidakis K, Ercoli C, Elad S. Challenges in implant-supported dental treatment in patients with Sjogren’s syndrome: a case report and literature review. Quintessence Int. 2016;47(6):515–24.

Ergun S, Katz J, Cifter ED, Koray M, Esen BA, Tanyeri H. Implant-supported oral rehabilitation of a patient with systemic lupus erythematosus: case report and review of the literature. Quintessence Int. 2010;41(10):863–7.

Krennmair G, Seemann R, Piehslinger E. Dental implants in patients with rheumatoid arthritis: clinical outcome and peri-implant findings. J Clin Periodontol. 2010;37(10):928–36.

Weinlander M, Krennmair G, Piehslinger E. Implant prosthodontic rehabilitation of patients with rheumatic disorders: a case series report. Int J Prosthodont. 2010;23(1):22–8.

Westhoff G, Doerner TDORACI, Cobarrubias K, Dietrich T, Zink A. SAT0223 Dental implants are a treatment option in patients with Sjögren’s syndrome. Ann Rheum Dis. 2014;71(Suppl 3):547.2–547.

Zigdon H, Gutmacher Z, Teich S, Levin L. Full-mouth rehabilitation using dental implants in a patient with scleroderma. Quintessence Int. 2011;42(9):781–5.

de Mendonça IM, Finger Stadler A, Vale Nicolau G, Naval Machado MÂ, Soares de Lima AA, Compagnoni Martins M. Management of Sjogren’s syndrome patient: a case report of prosthetic rehabilitation with 6-year follow-up. Case Rep Dent. 2014;2014(61):761251–5 Hindawi.

Esposito SJ, Camisa C, Morgan M. Implant retained overdentures for two patients with severe lichen planus: a clinical report. J Prosthet Dent. 2003;89(1):6–10.

Marini E, Spink MJ, Messina AM. Peri-implant primary squamous cell carcinoma: a case report with 5 years’ follow-up. J Oral Maxillofac Surg. 2013;71(2):322–6.

Altin N, Ergun S, Katz J, Sancakli E, Koray M, Tanyeri H. Implant-supported oral rehabilitation of a patient with pemphigus vulgaris: a clinical report. J Prosthodont 2013;22(7):581–586. Wiley/Blackwell (10.1111).

Binon PP. Thirteen-year follow-up of a mandibular implant-supported fixed complete denture in a patient with Sjogren’s syndrome: a clinical report. J Prosthet Dent. 2005;94(5):409–13.

Payne AG, Lownie JF, Van Der Linden WJ. Implant-supported prostheses in patients with Sjögren’s syndrome: a clinical report on three patients. Int J Oral Maxillofac Implants. 1997;12(5):679–85.

Ella B, Lasserre J-F, Blanchard J-P, Fricain JC. A 4-year follow-up of two complete mandibular implant-supported removable prostheses in a patient with severe rheumatoid polyarthritis: case report. Int J Oral Maxillofac Implants. 2011;26(2):e19–22.

Alsaadi G, Quirynen M, Komárek A, van Steenberghe D. Impact of local and systemic factors on the incidence of oral implant failures, up to abutment connection. J Clin Periodontol. 2007;34(7):610–7.

Montebugnoli L, Venturi M, Cervellati F. Bone response to submerged implants in organ transplant patients: a prospective controlled study. Int J Oral Maxillofac Implants. 2012;27(6):1494–500.

Montebugnoli L, Venturi M, Cervellati F, Servidio D, Vocale C, Pagan F, et al. Peri-implant response and microflora in organ transplant patients 1 year after prosthetic loading: a prospective controlled study. Clin Implant Dent Relat Res. 2014;17(5):972–82.

Gu L, Wang Q, Yu Y-C. Eleven dental implants placed in a liver transplantation patient: a case report and 5-year clinical evaluation. Chin Med J. 2011;124(3):472–5.

Heckmann SM, Heckmann JG, Linke JJ, Hohenberger W, Mombelli A. Implant therapy following liver transplantation: clinical and microbiological results after 10 years. J Periodontol. 2004;75(6):909–13.

Nakagawa A, Shitara N, Ayukawa Y, Koyano K, Nishimura K. Implant treatment followed by living donor lung transplant: a follow-up case report. J Prosthodont Res. 2014;58(2):127–31.

Gu L, Yu Y-C. Clinical outcome of dental implants placed in liver transplant recipients after 3 years: a case series. Transplant Proc. 2011;43(7):2678–82.

Campo J, Cano J, del Romero J, Hernando V, Rodríguez C, Bascones A. Oral complication risks after invasive and non-invasive dental procedures in HIV-positive patients. Oral Dis. 2007;13(1):110–116. Wiley/Blackwell (10.1111).

Kolhatkar S, Mason SA, Janic A, Bhola M, Haque S, Winkler JR. Surgical crown lengthening in a population with human immunodeficiency virus: a retrospective analysis. J Periodontol. 2012;83(3):344–53.

Lin CA, Takemoto S, Kandemir U, Kuo AC. Mid-term outcomes in HIV-positive patients after primary total hip or knee arthroplasty. J Arthroplast. 2014;29(2):277–82.

Ata-Ali J, Ata-Ali F, Di-Benedetto N, Bagan L, Bagan JV. Does HIV infection have an impact upon dental implant osseointegration? A systematic review. Med Oral Patol Oral Cir Bucal. 2015;20(3):e347–56.

Ata-Ali J, Ata-Ali F. Do antibiotics decrease implant failure and postoperative infections? A systematic review and meta-analysis. Int J Oral Maxillofac Surg. 2014;43(1):68–74.

Keenan JR, Veitz-Keenan A. Antibiotic prophylaxis for dental implant placement? Evid Based Dent. 2015;16(2):52–53. Nature Publishing Group.

Friedlaender GE, Tross RB, Doganis AC, Kirkwood JM, Baron R. Effects of chemotherapeutic agents on bone. I. Short-term methotrexate and doxorubicin (adriamycin) treatment in a rat model. J Bone Joint Surg Am. 1984;66(4):602–7.

Young DR, Virolainen P, Inoue N, Frassica FJ, Chao EYS. The short-term effects of cisplatin chemotherapy on bone turnover. J Bone Miner Res 1997;12(11):1874–1882. Wiley-Blackwell.

Karr RA, Kramer DC, Toth BB. Dental implants and chemotherapy complications. J Prosthet Dent. 1992;67(5):683–7.

Chrcanovic BR, Albrektsson T, Wennerberg A. Dental implants in patients receiving chemotherapy: a meta-analysis. Implant Dent. 2016;25(2):261–71.

Smith DA, Germolec DR. Introduction to immunology and autoimmunity. Environ Health Perspect. 1999;107:661.

Cooper GS, Bynum MLK, Somers EC. Recent insights in the epidemiology of autoimmune diseases: improved prevalence estimates and understanding of clustering of diseases. J Autoimmun. 2009;33(3–4):197–207.

Weng X, Liu L, Barcellos LF, Allison JE, Herrinton LJ. Clustering of inflammatory bowel disease with immune mediated diseases among members of a northern california-managed care organization. Am J Gastroenterol. 2007;102(7):1429–35 15th ed. Nature Publishing Group.

Quirynen M, De Soete M, van Steenberghe D. Infectious risks for oral implants: a review of the literature. Clin Oral Implants Res. 2002;13(1):1–19.

Esposito M, Hirsch JM, Lekholm U, Thomsen P. Biological factors contributing to failures of osseointegrated oral implants. (I). Success criteria and epidemiology. Eur J Oral Sci. 1998;106(1):527–51.

Rustemeyer J, Bremerich A. Necessity of surgical dental foci treatment prior to organ transplantation and heart valve replacement. Clin Oral Investig. 2007;11(2):171–4.

Perdigão JPV, de Almeida PC, Rocha TDS, Mota MRL, Soares ECS, Alves APNN, et al. Postoperative bleeding after dental extraction in liver pretransplant patients. J Oral Maxillofac Surg. 2012;70(3):e177–84.