Dementia and mortality in persons with Down’s syndrome

Journal of Intellectual Disability Research - Tập 50 Số 10 - Trang 768-777 - 2006
Antonia Coppus1, Heleen M. Evenhuis2, Gert‐Jan Verberne3, Frank E. Visser4, Willem A. van Gool5, Piet Eikelenboom5, Cornelia van Duijin1
1Department of Epidemiology & Biostatistics, Erasmus MC, Rotterdam, The Netherlands
2Department of General Practice, Erasmus MC, Rotterdam, The Netherlands
3Centre for Intellectually Disabled, De Wendel, Venray, the Netherlands
4Centre for Intellectually Disabled, ’s-Heerenloo, Ermelo, the Netherlands
5Department of Neurology, Academic Medical Centre, Amsterdam, The Netherlands

Tóm tắt

AbstractBackground  Numerous studies have documented that persons with Down’s syndrome (DS) are at an increased risk of Alzheimer’s disease (AD). However, at present it is still not clear whether or not all persons with DS will develop dementia as they reach old age.Methods  We studied 506 people with DS, aged 45 years and above. A standardized assessment of cognitive, functional and physical status was repeated annually. If deterioration occurred, the patients were examined and the differential diagnosis of dementia was made according to the revised Dutch consensus protocol and according to the ICD‐10 Symptom Checklist for Mental Disorders. We compared our findings with those reported in the literature.Results  The overall prevalence of dementia was 16.8%. Up to the age of 60, the prevalence of dementia doubled with each 5‐year interval. Up to the age of 49, the prevalence is 8.9%, from 50 to 54, it is 17.7%, and from 55 to 59, it is 32.1%. In the age category of 60 and above, there is a small decrease in prevalence of dementia to 25.6%. The lack of increase after the age of 60 may be explained by the increased mortality among elderly demented DS patients (44.4%) in comparison with non‐demented patients (10.7%) who we observed during a 3.3‐year follow‐up. There was no decrease in incidence of dementia in the age group of 60 and above. Our findings are very similar to those published in the literature. Patients with dementia were more frequently treated with antiepileptic, antipsychotic and antidepressant drugs. The history of depression was strongly associated with dementia.Conclusions  Our study is one of the largest population‐based studies to date. We found that despite the exponential increase in prevalence with age, the prevalence of dementia in the oldest persons with DS was not higher than 25.6%.

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Journal of Intellectual Disability Research

Tập 50 Số 10

768-777

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