Delivery of Insulin via Skin Route for the Management of Diabetes Mellitus: Approaches for Breaching the Obstacles

Tabish, 2007, Is Diabetes Becoming the Biggest Epidemic of the Twenty-first Century?, Int. J. Health Sci. (Qassim), 1, V

Lin, 2020, Global, regional, and national burden and trend of diabetes in 195 countries and territories: An analysis from 1990 to 2025, Sci. Rep., 10, 14790, 10.1038/s41598-020-71908-9

Zhao, 2020, Drug Delivery System in the Treatment of Diabetes Mellitus, Front. Bioeng. Biotechnol., 8, 880, 10.3389/fbioe.2020.00880

Rai, 2016, Novel drug delivery system: An immense hope for diabetics, Drug Deliv., 23, 2371, 10.3109/10717544.2014.991001

Saeedi, 2019, Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9(th) edition, Diabetes Res. Clin. Pract., 157, 107843, 10.1016/j.diabres.2019.107843

Cheng, 2019, Prevalence of Diabetes by Race and Ethnicity in the United States, 2011–2016, JAMA, 322, 2389, 10.1001/jama.2019.19365

Rosenfeld, 2002, Insulin: Discovery and controversy, Clin. Chem., 48, 2270, 10.1093/clinchem/48.12.2270

Verma, 2014, Emerging Trends in Noninvasive Insulin Delivery, J. Pharm. (Cairo), 2014, 378048

Mo, 2014, Emerging micro- and nanotechnology based synthetic approaches for insulin delivery, Chem. Soc. Rev., 43, 3595, 10.1039/c3cs60436e

Arida, 2008, Recent challenges in insulin delivery systems: A review, Indian J. Pharm. Sci., 70, 278, 10.4103/0250-474X.42968

Kesavadev, 2020, Evolution of Insulin Delivery Devices: From Syringes, Pens, and Pumps to DIY Artificial Pancreas, Diabetes Ther., 11, 1251, 10.1007/s13300-020-00831-z

Selam, 2010, Evolution of diabetes insulin delivery devices, J. Diabetes Sci. Technol., 4, 505, 10.1177/193229681000400302

Penfornis, 2011, Evolution of devices in diabetes management, Diabetes Technol. Ther., 13, S93, 10.1089/dia.2011.0058

Yaturu, 2013, Insulin therapies: Current and future trends at dawn, World J. Diabetes, 4, 1, 10.4239/wjd.v4.i1.1

Gradel, 2018, Factors Affecting the Absorption of Subcutaneously Administered Insulin: Effect on Variability, J. Diabetes Res., 2018, 1205121, 10.1155/2018/1205121

Khan, 2019, Transdermal patches: Design and current approaches to painless drug delivery, Acta Pharm., 69, 197, 10.2478/acph-2019-0016

Morishita, 2007, Current challenges in non-invasive insulin delivery systems: A comparative review, Adv. Drug Deliv. Rev., 59, 1521, 10.1016/j.addr.2007.08.019

Ng, 2020, Transdermal drug delivery systems in diabetes management: A review, Asian J. Pharm. Sci., 15, 13, 10.1016/j.ajps.2019.04.006

Hadebe, S.I., Ngubane, P.S., Serumula, M.R., and Musabayane, C.T. (2014). Transdermal delivery of insulin by amidated pectin hydrogel matrix patch in streptozotocin-induced diabetic rats: Effects on some selected metabolic parameters. PLoS ONE, 9.

Antunes, 2020, Stratum corneum lipid matrix with unusual packing: A molecular dynamics study, Colloids Surf. B Biointerfaces, 190, 110928, 10.1016/j.colsurfb.2020.110928

Opatha, S.A.T., Titapiwatanakun, V., and Chutoprapat, R. (2020). Transfersomes: A Promising Nanoencapsulation Technique for Transdermal Drug Delivery. Pharmaceutics, 12.

Lalatsa, 2020, Transferosomes as nanocarriers for drugs across the skin: Quality by design from lab to industrial scale, Int. J. Pharm., 573, 118817, 10.1016/j.ijpharm.2019.118817

Mitragotri, 2000, Determination of threshold energy dose for ultrasound-induced transdermal drug transport, J. Control. Release, 63, 41, 10.1016/S0168-3659(99)00178-9

Prausnitz, 2008, Transdermal drug delivery, Nat. Biotechnol., 26, 1261, 10.1038/nbt.1504

Sen, 2002, Transdermal insulin delivery using lipid enhanced electroporation, Biochim. Biophys. Acta, 1564, 5, 10.1016/S0005-2736(02)00453-4

Pillai, 2003, Transdermal iontophoresis of insulin. II. Physicochemical considerations, Int. J. Pharm., 254, 271, 10.1016/S0378-5173(03)00034-6

Sintov, 2007, Topical iodine facilitates transdermal delivery of insulin, J. Control. Release, 118, 185, 10.1016/j.jconrel.2006.12.006

Cevc, 1998, Ultraflexible vesicles, Transfersomes, have an extremely low pore penetration resistance and transport therapeutic amounts of insulin across the intact mammalian skin, Biochim. Biophys. Acta, 1368, 201, 10.1016/S0005-2736(97)00177-6

King, 2002, Transdermal delivery of insulin from a novel biphasic lipid system in diabetic rats, Diabetes Technol. Ther., 4, 479, 10.1089/152091502760306562

Zhang, 2019, Advances in transdermal insulin delivery, Adv. Drug Deliv. Rev., 139, 51, 10.1016/j.addr.2018.12.006

Jin, 2018, Insulin delivery systems combined with microneedle technology, Adv. Drug Deliv. Rev., 127, 119, 10.1016/j.addr.2018.03.011

Gill, 2008, Effect of microneedle design on pain in human volunteers, Clin. J. Pain, 24, 585, 10.1097/AJP.0b013e31816778f9

Sivamani, 2005, Clinical microneedle injection of methyl nicotinate: Stratum corneum penetration, Skin Res. Technol., 11, 152, 10.1111/j.1600-0846.2005.00107.x

McAllister, 2003, Microfabricated needles for transdermal delivery of macromolecules and nanoparticles: Fabrication methods and transport studies, Proc. Natl. Acad. Sci. USA, 100, 13755, 10.1073/pnas.2331316100

Coulman, 2009, Microneedle mediated delivery of nanoparticles into human skin, Int. J. Pharm., 366, 190, 10.1016/j.ijpharm.2008.08.040

Martanto, 2006, Microinfusion using hollow microneedles, Pharm. Res., 23, 104, 10.1007/s11095-005-8498-8

Kaushik, 2001, Lack of pain associated with microfabricated microneedles, Anesth. Analg., 92, 502, 10.1213/00000539-200102000-00041

Prausnitz, 2004, Microneedles for transdermal drug delivery, Adv. Drug Deliv. Rev., 56, 581, 10.1016/j.addr.2003.10.023

Wu, 2010, Sustained release of insulin through skin by intradermal microdelivery system, Biomed. Microdevices, 12, 665, 10.1007/s10544-010-9419-0

Sullivan, 2010, Dissolving polymer microneedle patches for influenza vaccination, Nat. Med., 16, 915, 10.1038/nm.2182

Lee, 2008, Dissolving microneedles for transdermal drug delivery, Biomaterials, 29, 2113, 10.1016/j.biomaterials.2007.12.048

Ling, 2013, Dissolving polymer microneedle patches for rapid and efficient transdermal delivery of insulin to diabetic rats, Acta Biomater., 9, 8952, 10.1016/j.actbio.2013.06.029

Chen, 2015, Poly-gamma-glutamic acid microneedles with a supporting structure design as a potential tool for transdermal delivery of insulin, Acta Biomater., 24, 106, 10.1016/j.actbio.2015.06.021

Ito, 2012, Transdermal insulin application system with dissolving microneedles, Diabetes Technol. Ther., 14, 891, 10.1089/dia.2012.0096

Liu, 2012, The development and characteristics of novel microneedle arrays fabricated from hyaluronic acid, and their application in the transdermal delivery of insulin, J. Control. Release, 161, 933, 10.1016/j.jconrel.2012.05.030

Zhou, 2010, Transdermal delivery of insulin using microneedle rollers in vivo, Int. J. Pharm., 392, 127, 10.1016/j.ijpharm.2010.03.041

Chen, 2018, Preparation, properties and challenges of the microneedles-based insulin delivery system, J. Control. Release, 288, 173, 10.1016/j.jconrel.2018.08.042

Liu, 2020, Microneedles for transdermal diagnostics: Recent advances and new horizons, Biomaterials, 232, 119740, 10.1016/j.biomaterials.2019.119740

Wang, 2020, Smart microneedle patches for rapid, and painless transdermal insulin delivery, J. Mater. Chem. B, 8, 9335, 10.1039/D0TB01822H

Zhang, Y., Wu, M., Tan, D., Liu, Q., Xia, R., Chen, M., Liu, Y., Xue, L., and Lei, Y. (2020). A dissolving and glucose-responsive insulin-releasing microneedle patch for type 1 diabetes therapy. J. Mater. Chem. B.

Kim, 2020, Implantable powder-carrying microneedles for transdermal delivery of high-dose insulin with enhanced activity, Biomaterials, 232, 119733, 10.1016/j.biomaterials.2019.119733

Gupta, 2011, Kinetics of skin resealing after insertion of microneedles in human subjects, J. Control. Release, 154, 148, 10.1016/j.jconrel.2011.05.021

Haq, 2009, Clinical administration of microneedles: Skin puncture, pain and sensation, Biomed. Microdevices, 11, 35, 10.1007/s10544-008-9208-1

Burton, 2011, Rapid intradermal delivery of liquid formulations using a hollow microstructured array, Pharm. Res., 28, 31, 10.1007/s11095-010-0177-8

Bariya, 2012, Microneedles: An emerging transdermal drug delivery system, J. Pharm. Pharmacol., 64, 11, 10.1111/j.2042-7158.2011.01369.x

Kovacik, 2020, Permeation enhancers in transdermal drug delivery: Benefits and limitations, Expert Opin. Drug Deliv., 17, 145, 10.1080/17425247.2020.1713087

Sinha, 2000, Permeation enhancers for transdermal drug delivery, Drug Dev. Ind. Pharm., 26, 1131, 10.1081/DDC-100100984

Karande, 2009, Enhancement of transdermal drug delivery via synergistic action of chemicals, Biochim. Biophys. Acta, 1788, 2362, 10.1016/j.bbamem.2009.08.015

Krishnaiah, 2006, Effect of nerodilol and carvone on in vitro permeation of nicorandil across rat epidermal membrane, Drug Dev. Ind. Pharm., 32, 423, 10.1080/03639040500528939

Ita, 2015, Chemical Penetration Enhancers for Transdermal Drug Delivery—Success and Challenges, Curr. Drug Deliv., 12, 645, 10.2174/1567201812666150804104600

Williams, 2004, Penetration enhancers, Adv. Drug Deliv. Rev., 56, 603, 10.1016/j.addr.2003.10.025

Harjoh, 2020, Transdermal insulin delivery with microwave and fatty acids as permeation enhancers, Int. J. Pharm., 584, 119416, 10.1016/j.ijpharm.2020.119416

Yerramsetty, 2010, Effect of different enhancers on the transdermal permeation of insulin analog, Int. J. Pharm., 398, 83, 10.1016/j.ijpharm.2010.07.029

Rastogi, 2010, Investigation on the synergistic effect of a combination of chemical enhancers and modulated iontophoresis for transdermal delivery of insulin, Drug Dev. Ind. Pharm., 36, 993, 10.3109/03639041003682012

Rastogi, 2005, Effect of chemical penetration enhancer and iontophoresis on the in vitro percutaneous absorption enhancement of insulin through porcine epidermis, Pharm. Dev. Technol., 10, 97, 10.1081/PDT-49679

Li, 2008, Transdermal delivery of insulin using trypsin as a biochemical enhancer, Biol. Pharm. Bull., 31, 1574, 10.1248/bpb.31.1574

Li, 2009, Trypsin as a novel potential absorption enhancer for improving the transdermal delivery of macromolecules, J. Pharm. Pharmacol., 61, 1005, 10.1211/jpp.61.08.0003

Priborsky, 1987, Combination effect of penetration enhancers and propylene glycol on in vitro transdermal absorption of insulin, Drug Des. Deliv., 2, 91

Pillai, 2003, Transdermal iontophoresis of insulin. V. Effect of terpenes, J. Control. Release, 88, 287, 10.1016/S0168-3659(03)00065-8

Pillai, 2003, Transdermal delivery of insulin from poloxamer gel: Ex vivo and in vivo skin permeation studies in rat using iontophoresis and chemical enhancers, J. Control. Release, 89, 127, 10.1016/S0168-3659(03)00094-4

Isaac, 2012, Transdermal patches: The emerging mode of drug delivery system in psychiatry, Ther. Adv. Psychopharmacol., 2, 255, 10.1177/2045125312458311

Kurmi, 2017, Transdermal Drug Delivery: Opportunities and Challenges for Controlled Delivery of Therapeutic Agents Using Nanocarriers, Curr. Drug Metab., 18, 481, 10.2174/1389200218666170222150555

Gandhi, 2012, Transdermal drug delivery—A review, Int. J. Res. Pharm. Sci., 3, 379

Sudam, 2016, A Comprehensive Review on: Transdermal drug delivery systems, Int. J. Biomed. Adv. Res., 7, 147, 10.7439/ijbar.v7i4.3131

Pagneux, 2020, Electrothermal patches driving the transdermal delivery of insulin, Nanoscale Horiz., 5, 663, 10.1039/C9NH00576E

King, 2003, Evidence for lymphatic transport of insulin by topically applied biphasic vesicles, J. Pharm. Pharmacol., 55, 1339, 10.1211/0022357021918

Mbaye, 2009, Development of Ethylcellulose/Eudragit matrix for controlled and continuous release of insulin, Mali. Med., 24, 11

Bohannon, 2011, Comparison of a novel insulin bolus-patch with pen/syringe injection to deliver mealtime insulin for efficacy, preference, and quality of life in adults with diabetes: A randomized, crossover, multicenter study, Diabetes Technol. Ther., 13, 1031, 10.1089/dia.2011.0047

Qiu, 2012, Novel lyophilized hydrogel patches for convenient and effective administration of microneedle-mediated insulin delivery, Int. J. Pharm., 437, 51, 10.1016/j.ijpharm.2012.07.035

Fukushima, 2010, Pharmacokinetic and pharmacodynamic evaluation of insulin dissolving microneedles in dogs, Diabetes Technol. Ther., 12, 465, 10.1089/dia.2009.0176

Sibiya, 2017, Cardioprotective effects of pectin-insulin patch in streptozotocin-induced diabetic rats, J. Diabetes, 9, 1073, 10.1111/1753-0407.12538

Seah, 2018, Recent advances in ultrasound-based transdermal drug delivery, Int. J. Nanomed., 13, 7749, 10.2147/IJN.S174759

Oberli, 2014, Ultrasound-enhanced transdermal delivery: Recent advances and future challenges, Ther. Deliv., 5, 843, 10.4155/tde.14.32

Alkilani, 2015, Transdermal Drug Delivery: Innovative Pharmaceutical Developments Based on Disruption of the Barrier Properties of the stratum corneum, Pharmaceutics, 7, 438, 10.3390/pharmaceutics7040438

Merino, 2003, Skin permeability enhancement by low frequency sonophoresis: Lipid extraction and transport pathways, J. Pharm. Sci., 92, 1138, 10.1002/jps.10370

Jabbari, 2015, Developing a Commercial Air Ultrasonic Ceramic Transducer to Transdermal Insulin Delivery, J. Med. Signals Sens., 5, 117, 10.4103/2228-7477.157618

Feiszthuber, 2015, Cavitation-enhanced delivery of insulin in agar and porcine models of human skin, Phys. Med. Biol., 60, 2421, 10.1088/0031-9155/60/6/2421

Park, 2008, Dose comparison of ultrasonic transdermal insulin delivery to subcutaneous insulin injection, Int. J. Nanomed., 3, 335

Murthy, 2004, Temperature influences the postelectroporation permeability state of the skin, J. Pharm. Sci., 93, 908, 10.1002/jps.20016

Mohammad, 2016, Electroporation Parameters for Successful Transdermal Delivery of Insulin, Am. J. Ther., 23, e1560, 10.1097/MJT.0000000000000198

Tokumoto, 2006, Effect of electroporation and pH on the iontophoretic transdermal delivery of human insulin, Int. J. Pharm., 326, 13, 10.1016/j.ijpharm.2006.07.002

Murthy, 2006, Lipid and electroosmosis enhanced transdermal delivery of insulin by electroporation, J. Pharm. Sci., 95, 2041, 10.1002/jps.20682

Rawat, 2008, Transdermal delivery by iontophoresis, Indian J. Pharm. Sci., 70, 5, 10.4103/0250-474X.40324

Vranic, 2003, Iontophoresis: Fundamentals, developments and application, Bosn. J. Basic Med. Sci., 3, 54, 10.17305/bjbms.2003.3530

Dhote, 2012, Iontophoresis: A potential emergence of a transdermal drug delivery system, Sci. Pharm., 80, 1, 10.3797/scipharm.1108-20

Hao, 1995, Transdermal iontophoresis of insulin: Effect of penetration enhancers on blood glucose level in diabetic rats, Yao Xue Xue Bao, 30, 776

Pan, 2002, The enhancing effect of electroporation and iontophoresis on the permeation of insulin through human skin, Yao Xue Xue Bao, 37, 649

Langkjaer, 1998, Iontophoresis of monomeric insulin analogues in vitro: Effects of insulin charge and skin pretreatment, J. Control. Release, 51, 47, 10.1016/S0168-3659(97)00155-7

Kajimoto, 2011, Noninvasive and persistent transfollicular drug delivery system using a combination of liposomes and iontophoresis, Int. J. Pharm., 403, 57, 10.1016/j.ijpharm.2010.10.021

Chen, 2009, Iontophoresis-driven penetration of nanovesicles through microneedle-induced skin microchannels for enhancing transdermal delivery of insulin, J. Control. Release, 139, 63, 10.1016/j.jconrel.2009.05.031

Akbarzadeh, 2013, Liposome: Classification, preparation, and applications, Nanoscale Res. Lett., 8, 102, 10.1186/1556-276X-8-102

Biju, 2006, Vesicular systems: An overview, Indian J. Pharm. Sci., 68, 141, 10.4103/0250-474X.25707

Ogiso, 1996, Dissociation of insulin oligomers and enhancement of percutaneous absorption of insulin, Biol. Pharm. Bull., 19, 1049, 10.1248/bpb.19.1049

Cevc, 2003, Transdermal drug delivery of insulin with ultradeformable carriers, Clin. Pharmacokinet., 42, 461, 10.2165/00003088-200342050-00004

Marwah, 2016, Development of transferosomal gel for trans-dermal delivery of insulin using iodine complex, Drug Deliv., 23, 1636, 10.3109/10717544.2016.1155243

Malakar, 2012, Formulation, optimization and evaluation of transferosomal gel for transdermal insulin delivery, Saudi Pharm. J., 20, 355, 10.1016/j.jsps.2012.02.001

Date, 2007, Microemulsions: Applications in transdermal and dermal delivery, Crit. Rev. Ther. Drug Carr. Syst., 24, 547, 10.1615/CritRevTherDrugCarrierSyst.v24.i6.20

Shukla, 2018, Biomedical applications of microemulsion through dermal and transdermal route, Biomed. Pharmacother., 108, 1477, 10.1016/j.biopha.2018.10.021

Santos, 2008, Application of microemulsions in dermal and transdermal drug delivery, Skin Pharmacol. Physiol., 21, 246, 10.1159/000140228

Akram, 2013, Design and development of insulin emulgel formulation for transdermal drug delivery and its evaluation, Pak. J. Pharm. Sci., 26, 323

Malakar, 2011, Development and evaluation of microemulsions for transdermal delivery of insulin, ISRN Pharm., 2011, 780150

Ghasemiyeh, 2020, Potential of Nanoparticles as Permeation Enhancers and Targeted Delivery Options for Skin: Advantages and Disadvantages, Drug Des. Dev. Ther., 14, 3271, 10.2147/DDDT.S264648

Lauterbach, 2015, Applications and limitations of lipid nanoparticles in dermal and transdermal drug delivery via the follicular route, Eur. J. Pharm. Biopharm., 97, 152, 10.1016/j.ejpb.2015.06.020

Kakadia, 2015, Lipid nanoparticles for dermal drug delivery, Curr. Pharm. Des., 21, 2823, 10.2174/1381612821666150428143730

Zhao, 2010, Insulin nanoparticles for transdermal delivery: Preparation and physicochemical characterization and in vitro evaluation, Drug Dev. Ind. Pharm., 36, 1177, 10.3109/03639041003695089

Andrews, 2011, Transdermal insulin delivery using microdermabrasion, Pharm. Res., 28, 2110, 10.1007/s11095-011-0435-4

Marwah, 2016, Permeation enhancer strategies in transdermal drug delivery, Drug Deliv., 23, 564, 10.3109/10717544.2014.935532

Mitragotri, 1996, Transdermal drug delivery using low-frequency sonophoresis, Pharm. Res., 13, 411, 10.1023/A:1016096626810

Lavon, 2004, Ultrasound and transdermal drug delivery, Drug Discov. Today, 9, 670, 10.1016/S1359-6446(04)03170-8

Boucaud, 2002, Effect of sonication parameters on transdermal delivery of insulin to hairless rats, J. Control. Release, 81, 113, 10.1016/S0168-3659(02)00054-8

Schlicher, 2006, Mechanism of intracellular delivery by acoustic cavitation, Ultrasound Med. Biol., 32, 915, 10.1016/j.ultrasmedbio.2006.02.1416

Park, 2014, Sonophoresis in transdermal drug deliverys, Ultrasonics, 54, 56, 10.1016/j.ultras.2013.07.007

Ita, K. (2016). Perspectives on Transdermal Electroporation. Pharmaceutics, 8.

Chen, 2020, Electroporation-enhanced transdermal drug delivery: Effects of logP, pKa, solubility and penetration time, Eur. J. Pharm. Sci., 151, 105410, 10.1016/j.ejps.2020.105410

Akhtar, 2020, Non-invasive drug delivery technology: Development and current status of transdermal drug delivery devices, techniques and biomedical applications, Biomed. Tech. Eng., 65, 243, 10.1515/bmt-2019-0019

Pirc, 2020, Mechanistic view of skin electroporation—models and dosimetry for successful applications: An expert review, Expert Opin. Drug Deliv., 17, 689, 10.1080/17425247.2020.1745772

Rastogi, 2010, Electroporation of polymeric nanoparticles: An alternative technique for transdermal delivery of insulin, Drug Dev. Ind. Pharm., 36, 1303, 10.3109/03639041003786193

Batheja, 2006, Transdermal iontophoresis, Expert Opin. Drug Deliv., 3, 127, 10.1517/17425247.3.1.127

Panchagnula, 2000, Transdermal iontophoresis revisited, Curr. Opin. Chem. Biol., 4, 468, 10.1016/S1367-5931(00)00111-3

Pillai, 2003, Transdermal iontophoresis of insulin. Part 1: A study on the issues associated with the use of platinum electrodes on rat skin, J. Pharm. Pharmacol., 55, 1505, 10.1211/0022357022197

Pillai, 2004, Transdermal iontophoresis of insulin: III. Influence of electronic parameters, Methods Find. Exp. Clin. Pharmacol., 26, 399, 10.1358/mf.2004.26.6.831314

Pillai, 2004, Transdermal iontophoresis of insulin: IV. Influence of chemical enhancers, Int. J. Pharm., 269, 109, 10.1016/j.ijpharm.2003.09.032

Pillai, 2004, Transdermal iontophoresis of insulin. VI. Influence of pretreatment with fatty acids on permeation across rat skin, Skin Pharmacol. Physiol., 17, 289, 10.1159/000081114

Li, 2020, Liposomes modified with bio-substances for cancer treatment, Biomater. Sci., 23, 6442, 10.1039/D0BM01531H

Shah, 2020, Liposomes: Advancements and innovation in the manufacturing process, Adv. Drug Deliv. Rev., 154–155, 102, 10.1016/j.addr.2020.07.002

Pace, 2020, Formulation and evaluation of itraconazole liposomes for Hedgehog pathway inhibition, J. Liposome Res., 30, 305, 10.1080/08982104.2019.1668011

Rai, 2017, Transfersomes as versatile and flexible nano-vesicular carriers in skin cancer therapy: The state of the art, Nano Rev. Exp., 8, 1325708, 10.1080/20022727.2017.1325708

Ita, 2016, Current Status of Ethosomes and Elastic Liposomes in Dermal and Transdermal Drug Delivery, Curr. Pharm. Des., 22, 5120, 10.2174/1381612822666160511150228

Kumar, 2012, Ultra-adaptable nanovesicular systems: A carrier for systemic delivery of therapeutic agents, Drug Discov. Today, 17, 1233, 10.1016/j.drudis.2012.06.013

Peltola, 2003, Microemulsions for topical delivery of estradiol, Int. J. Pharm., 254, 99, 10.1016/S0378-5173(02)00632-4

2010, Self-microemulsifying and microemulsion systems for transdermal delivery of indomethacin: Effect of phase transition, Colloids Surf. B Biointerfaces, 75, 595, 10.1016/j.colsurfb.2009.10.003

Sintov, 2006, Transdermal drug delivery using microemulsion and aqueous systems: Influence of skin storage conditions on the in vitro permeability of diclofenac from aqueous vehicle systems, Int. J. Pharm., 311, 55, 10.1016/j.ijpharm.2005.12.019

2008, Transdermal delivery of hydrocortisone from eucalyptus oil microemulsion: Effects of cosurfactants, Int. J. Pharm., 355, 285, 10.1016/j.ijpharm.2007.12.022

Zhu, 2020, Applications and delivery mechanisms of hyaluronic acid used for topical/transdermal delivery—A review, Int. J. Pharm., 578, 119127, 10.1016/j.ijpharm.2020.119127

Himes, 2011, Water-in-oil microemulsions for effective transdermal delivery of proteins, Expert Opin. Drug Deliv., 8, 537, 10.1517/17425247.2011.559458

Ferreira, 2020, Investigation of a Microemulsion Containing Clotrimazole and Itraconazole for Transdermal Delivery for the Treatment of Sporotrichosis, J. Pharm. Sci., 109, 1026, 10.1016/j.xphs.2019.10.009

Zhang, 2020, Enhancement of transdermal delivery of artemisinin using microemulsion vehicle based on ionic liquid and lidocaine ibuprofen, Colloids Surf. B Biointerfaces, 189, 110886, 10.1016/j.colsurfb.2020.110886

Laothaweerungsawat, 2020, Transdermal delivery enhancement of carvacrol from Origanum vulgare L. essential oil by microemulsion, Int. J. Pharm., 579, 119052, 10.1016/j.ijpharm.2020.119052

Bhalla, 2006, Microdermabrasion: Reappraisal and brief review of literature, Dermatol. Surg., 32, 809

Fujimoto, 2005, Effect of microdermabrasion on barrier capacity of stratum corneum, Chem. Pharm. Bull. (Tokyo), 53, 1014, 10.1248/cpb.53.1014

Freedman, 2001, The epidermal and dermal changes associated with microdermabrasion, Dermatol. Surg., 27, 1031

Lee, 2003, Lasers and microdermabrasion enhance and control topical delivery of vitamin C, J. Investig. Dermatol., 121, 1118, 10.1046/j.1523-1747.2003.12537.x

Fang, 2004, Enhancement of topical 5-aminolaevulinic acid delivery by erbium:YAG laser and microdermabrasion: A comparison with iontophoresis and electroporation, Br. J. Dermatol., 151, 132, 10.1111/j.1365-2133.2004.06051.x

Lee, 2006, Microdermabrasion as a novel tool to enhance drug delivery via the skin: An animal study, Dermatol. Surg., 32, 1013, 10.1097/00042728-200608000-00006

Gill, 2009, Selective removal of stratum corneum by microdermabrasion to increase skin permeability, Eur. J. Pharm. Sci., 38, 95, 10.1016/j.ejps.2009.06.004