Defenses against Oxidative Stress inNeisseria gonorrhoeae: a System Tailored for a Challenging Environment

Microbiology and Molecular Biology Reviews - Tập 70 Số 2 - Trang 344-361 - 2006
Kate L. Seib1, Hsing‐Ju Wu2, Stephen P. Kidd1, Michael A. Apicella3, Michael P. Jennings1, Alastair G. McEwan1
1The School of Molecular and Microbial Sciences & Centre for Metals in Biology, The University of Queensland, Brisbane 4072, Australia
2Core Facilities for Proteomics Research, Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan
3Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa 52242

Tóm tắt

SUMMARYNeisseria gonorrhoeaeis a host-adapted pathogen that colonizes primarily the human genitourinary tract. This bacterium encounters reactive oxygen and reactive nitrogen species as a consequence of localized inflammatory responses in the urethra of males and endocervix of females and also of the activity of commensal lactobacilli in the vaginal flora. This review describes recent advances in the understanding of defense systems against oxidative stress inN. gonorrhoeaeand shows that while some of its defenses have similarities to the paradigm established withEscherichia coli, there are also some key differences. These differences include the presence of a defense system against superoxide based on manganese ions and a glutathione-dependent system for defense against nitric oxide which is under the control of a novel MerR-like transcriptional regulator. An understanding of the defenses against oxidative stress inN. gonorrhoeaeand their regulation may provide new insights into the ways in which this bacterium survives challenges from polymorphonuclear leukocytes and urogenital epithelial cells.

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Microbiology and Molecular Biology Reviews

Tập 70 Số 2

344-361

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