Deciphering the Human Gut Microbiome of Urolithin Metabotypes: Association with Enterotypes and Potential Cardiometabolic Health Implications

Molecular Nutrition and Food Research - Tập 63 Số 4 - 2019
María Romo‐Vaquero1, Adrián Cortés‐Martín1, Viviana Loria‐Kohen2, Ana Ramírez de Molina2, Izaskun García‐Mantrana3, María Carmen Collado3, Juan Carlos Espı́n1, María V. Selma1
1Laboratory of Food & Health Research Group on Quality Safety and Bioactivity of Plant Foods, CEBAS‐CSIC 30100 Murcia Spain
2GENYAL Platform on Nutrition and Health, IMDEA Food Institute, CEI UAM + CSIC, 28049 Madrid, Spain
3Group of Lactic Bacteria and Probiotics, Department of Biotechnology, IATA-CSIC, 46980 Valencia, Spain

Tóm tắt

ScopeThe gut microbiota ellagitannin‐metabolizing phenotypes (i.e., urolithin metabotypes [UMs]) are proposed as potential cardiovascular disease (CVD) risk biomarkers because the host blood lipid profile is reported to be associated with specific UMs. However, the link for this association remains unknown so far.Methods and ResultsThe gut microbiome of 249 healthy individuals is analyzed using 16S rDNA sequencing analysis. Individuals are also stratified by UMs (UM‐A, UM‐B, and UM‐0) and enterotypes (Bacteroides, Prevotella, and Ruminococcus). Associations of UMs discriminating bacteria with CVD risk markers are investigated. Distribution and gut microbiota composition of UMs and enterotypes are not coincident. Almost half of the discriminating genera between UM‐A and UM‐B belongs to the Coriobacteriaceae family. UM‐B individuals present higher blood cholesterol levels and higher alpha‐diversity, including Coriobacteriaceae family, than those of UM‐A. Coriobacteriaceae, whose abundance is the highest in UM‐B, is positively correlated with total cholesterol, LDL cholesterol, and body mass index.ConclusionsResults herein suggest that the family Coriobacteriaceae could be a link between individuals’ UMs and their blood cholesterol levels. Further research is needed to explore the mechanisms of the host metabolic phenotype, including cholesterol excretion products, to modulate this bacterial family.

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Molecular Nutrition and Food Research

Tập 63 Số 4

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