Decade-Long Safety and Function of Retroviral-Modified Chimeric Antigen Receptor T Cells

American Association for the Advancement of Science (AAAS) - Tập 4 Số 132 - 2012
John Scholler1, Troy Brady2, Gwendolyn Binder-Scholl1, Wei‐Ting Hwang3, Gabriela Plesa1, Kristen Hege4, Ashley N. Vogel1, Michael Kalos1, James L. Riley2, Steven G. Deeks5, Ronald T. Mitsuyasu6, Wendy B. Bernstein7, Naomi Aronson8,7, Bruce L. Levine1, Frederic D. Bushman2, Carl H. June1
1Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104–6076, USA.
2Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104–6076, USA.
3Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104–6076, USA.
4Celgene Corporation, 1500 Owens Street, Suite 600, San Francisco, CA 94158, USA.
5Department of Medicine, University of California San Francisco, San Francisco, CA 94143, USA
6Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90035, USA.
7Walter Reed National Military Medical Center, Bethesda, MD, 20889, USA
8Uniformed Services University of the Health Sciences, Bethesda, MD 20814 USA

Tóm tắt

Adoptively transferred chimeric antigen receptor T cells have stable stem cell–like persistence for at least a decade and more than 500 years of patient safety.

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American Association for the Advancement of Science (AAAS)

Tập 4 Số 132

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