Daughter‐specific repression of <i>Saccharomyces cerevisiae HO</i>: Ash1 is the commander

EMBO Reports - Tập 5 Số 10 - Trang 953-957 - 2004
Maria Pia Cosma1
1Telethon Institute of Genetics and Medicine, Via P. Castellino 111, 80131 Naples, Italy

Tóm tắt

The GATA‐1‐like factor Ash1 is a repressor of the HO gene, which encodes an endonuclease that is responsible for mating‐type switching in the yeast Saccharomyces cerevisiae. A multi‐step programme, which involves a macromolecular protein complex, the secondary structure of ASH1 mRNA and the cell cytoskeleton, enables Ash1 to asymmetrically localize to the daughter cell nucleus in late anaphase and to repress HO transcription. The resulting Ash1 activity prevents the daughter cell from switching mating type. How does Ash1 inhibit transcription of HO exclusively in the daughter cell? In this review, a speculative model is proposed and discussed. Through its action as a daughter‐specific repressor, Ash1 can be considered to be an ancestral regulator of cell fate in eukaryotes.

Từ khóa


Tài liệu tham khảo

10.1091/mbc.12.9.2567

10.1016/S0960-9822(99)80260-7

10.1016/S1097-2765(00)80143-4

10.1016/S0092-8674(00)81048-X

10.1093/emboj/19.20.5514

10.1128/MCB.18.5.2884

10.1016/S1097-2765(02)00694-9

10.1016/S0960-9822(99)80144-4

10.1016/S1097-2765(02)00604-4

10.1016/S0092-8674(00)80740-0

10.1261/rna.5120803

10.1016/S0960-9822(99)80145-6

10.1128/mr.52.4.536-553.1988

10.1093/emboj/21.5.1158

10.1016/S0092-8674(00)81047-8

10.1016/S0092-8674(02)00905-4

10.1016/S0092-8674(02)00651-7

10.1016/S0092-8674(00)00081-7

10.1101/gad.13.11.1412

10.1083/jcb.200207101

10.1093/emboj/19.23.6592

10.1083/jcb.153.2.307

10.1126/science.277.5324.383

10.1073/pnas.98.4.1495

10.1242/jcs.112.10.1511

10.1016/0959-437X(93)90036-O

10.1146/annurev.ge.16.120182.002255

10.1016/S1097-2765(00)80216-6

10.1182/blood.V80.3.575.575

10.1002/bies.10362

10.1016/S0092-8674(00)81049-1

10.1038/38015

10.1073/pnas.080585897

10.1091/mbc.e02-09-0616

10.1016/S1097-2765(00)80286-5

10.1083/jcb.135.6.1485

10.1016/S0960-9822(03)00264-1

Thông tin
Thông tin xuất bản

EMBO Reports

Tập 5 Số 10

953-957

Thông tin tác giả