Phân loại dựa trên methyl hóa DNA và xác định các nhóm liên quan đến tiên lượng ung thư bàng quang

Cancer Cell International - Tập 20 - Trang 1-11 - 2020
Zijian Tian1,2, Lingfeng Meng1,2, Xingbo Long1, Tongxiang Diao1, Maolin Hu1, Miao Wang1, Ming Liu1, Jianye Wang1,2
1Department of Urology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China
2Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China

Tóm tắt

Ung thư bàng quang (BCA) là khối u đường tiết niệu phổ biến nhất, nhưng cơ chế bệnh sinh của nó chưa rõ ràng, và chiến lược điều trị liên quan hiếm khi được cập nhật. Trong những năm gần đây, việc hiểu biết sâu hơn về di truyền học biểu sinh của khối u đã đạt được, mang lại cơ hội mới cho việc phát hiện và điều trị ung thư. Chúng tôi đã xác định các địa điểm methyl hóa dự đoán dựa trên hồ sơ methyl hóa DNA của BCA trong cơ sở dữ liệu TCGA và xây dựng một nhóm tiên lượng đặc hiệu. Dựa trên sự phân cụm đồng nhất của 402 CpG, chúng tôi xác định bảy nhóm có liên quan đáng kể đến tỷ lệ sống sót. Sự khác biệt về mức độ methyl hóa DNA có liên quan đến giai đoạn T, giai đoạn N, giai đoạn M, độ ác tính, giới tính, tuổi, giai đoạn và tiên lượng. Cuối cùng, mô hình dự đoán đã được xây dựng bằng cách sử dụng mô hình hồi quy Cox và được xác minh bằng bộ dữ liệu kiểm tra; tiên lượng nhất quán với bộ dữ liệu đào tạo. Phân loại dựa trên methyl hóa DNA có liên quan chặt chẽ đến các đặc điểm lâm sàng và bệnh lý của BCA và xác định giá trị tiên lượng của từng loại biểu sinh. Do đó, những phát hiện của chúng tôi cung cấp cơ sở cho sự phát triển của các chiến lược điều trị đặc hiệu theo loại methyl hóa DNA cho ung thư bàng quang ở người.

Từ khóa

#ung thư bàng quang #methyl hóa DNA #tiên lượng #biểu sinh học #đặc điểm lâm sàng

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