DNA Topoisomerases: Structure, Function, and Mechanism

Annual Review of Biochemistry - Tập 70 Số 1 - Trang 369-413 - 2001
James J. Champoux1
1Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington 98195-7242, USA.

Tóm tắt

▪ Abstract  DNA topoisomerases solve the topological problems associated with DNA replication, transcription, recombination, and chromatin remodeling by introducing temporary single- or double-strand breaks in the DNA. In addition, these enzymes fine-tune the steady-state level of DNA supercoiling both to facilitate protein interactions with the DNA and to prevent excessive supercoiling that is deleterious. In recent years, the crystal structures of a number of topoisomerase fragments, representing nearly all the known classes of enzymes, have been solved. These structures provide remarkable insights into the mechanisms of these enzymes and complement previous conclusions based on biochemical analyses. Surprisingly, despite little or no sequence homology, both type IA and type IIA topoisomerases from prokaryotes and the type IIA enzymes from eukaryotes share structural folds that appear to reflect functional motifs within critical regions of the enzymes. The type IB enzymes are structurally distinct from all other known topoisomerases but are similar to a class of enzymes referred to as tyrosine recombinases. The structural themes common to all topoisomerases include hinged clamps that open and close to bind DNA, the presence of DNA binding cavities for temporary storage of DNA segments, and the coupling of protein conformational changes to DNA rotation or DNA movement. For the type II topoisomerases, the binding and hydrolysis of ATP further modulate conformational changes in the enzymes to effect changes in DNA topology.

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Tài liệu tham khảo

10.1017/S0033583598003424

10.1016/0092-8674(88)90163-8

Kaguni JM, 1984, Biol. Chem., 259, 8578, 10.1016/S0021-9258(17)39769-7

10.1074/jbc.274.23.16659

10.1016/0092-8674(89)90855-6

10.1016/0092-8674(90)90002-V

10.1023/A:1008270717294

10.1016/S0300-9084(98)80008-4

10.1002/(SICI)1098-1128(199707)17:4<367::AID-MED3>3.0.CO;2-U

10.1042/bst0270048

10.1016/S0966-842X(96)10085-8

10.1016/S0959-440X(96)80099-6

10.1016/S0959-440X(98)80006-7

10.1016/S0167-4781(98)00124-9

10.1016/S0969-2126(96)00014-7

10.1146/annurev.bi.65.070196.003223

10.1016/S0167-4781(99)00020-2

10.1016/S1054-3589(08)61143-6

10.1093/nar/26.22.5157

10.1038/386414a0

10.1073/pnas.93.1.106

10.1038/281456a0

10.1016/0042-6822(92)90558-7

10.1074/jbc.275.10.6915

10.1046/j.1365-2958.1998.00862.x

10.1016/S0167-4781(98)00128-6

10.1016/S0167-4781(98)00125-0

10.1016/S0167-4781(98)00126-2

10.1073/pnas.040576797

10.1073/pnas.030528397

Deleted in proof.

10.1074/jbc.275.11.8103

Champoux JJ, Been MD. 1980. InMechanistic Studies of DNA Replication and Genetic Recombination, ed. B Alberts, pp. 809–15. New York: Academic

10.1016/S0092-8674(00)81740-7

10.1074/jbc.271.35.21529

10.1074/jbc.271.49.31549

10.1101/gad.9.22.2859

Hiasa H, 1994, J. Biol. Chem., 269, 32655, 10.1016/S0021-9258(18)31684-3

DiGate RJ, 1988, J. Biol. Chem., 263, 13366, 10.1016/S0021-9258(18)37713-5

Hiasa H, 1994, J. Biol. Chem., 269, 2093, 10.1016/S0021-9258(17)42140-5

10.1016/S1097-2765(00)80354-8

10.1016/0168-6445(96)00015-0

10.1073/pnas.94.20.10606

10.1016/0167-4781(96)83596-2

de la Tour CB, 1998, J. Bacteriol., 180, 274, 10.1128/JB.180.2.274-281.1998

Slesarev AI, 1994, J. Biol. Chem., 269, 3295, 10.1016/S0021-9258(17)41862-X

10.1038/364735a0

10.1038/386329a0

10.1128/jb.172.12.6803-6808.1990

10.1016/S0092-8674(85)80028-3

10.1016/0092-8674(87)90518-6

10.1093/emboj/18.6.1701

10.1093/nar/27.20.4050

10.1093/nar/27.24.4715

10.1128/MCB.14.12.8391

Bennett RJ, 2000, J. Biol. Chem., 275, 26898, 10.1016/S0021-9258(19)61459-6

10.1073/pnas.92.7.2667

10.1073/pnas.90.14.6656

10.1128/MCB.16.12.6804

10.1016/S0092-8674(00)81018-1

Chen M, 1995, Oncol. Res., 7, 103

10.1016/0167-4781(95)00164-C

10.1126/science.287.5450.131

10.1073/pnas.95.3.1010

10.1074/jbc.275.3.1533

10.1126/science.272.5259.258

10.1016/0092-8674(95)90105-1

10.1093/nar/28.7.1647

10.1016/0022-2836(85)90075-0

10.1073/pnas.93.8.3653

10.1006/jmbi.1993.1474

Zhu CX, 1994, Biochem. Mol. Biol. Int., 33, 195

10.1006/bbrc.1998.9500

Tse-Dinh YC, 1991, J. Biol. Chem., 266, 14317, 10.1016/S0021-9258(18)98686-2

10.1016/0022-2836(86)90130-0

10.1002/prot.340060307

Zhu CX, 1995, Biochem. Mol. Biol. Int., 35, 375

10.1074/jbc.271.15.9039

10.1006/jmbi.2000.3841

10.1073/pnas.90.10.4753

10.1038/367138a0

10.1016/0022-2836(81)90516-7

10.1093/emboj/18.21.6177

Tse YC, 1980, J. Biol. Chem., 255, 5560, 10.1016/S0021-9258(19)70666-8

Dean FB, 1985, J. Biol. Chem., 260, 4984, 10.1016/S0021-9258(18)89169-4

10.1002/elps.1150181505

10.1021/bi00023a008

10.1073/pnas.78.2.843

10.1016/0092-8674(80)90174-9

Champoux JJ. 1990. InDNA Topology and Its Biological Effects, ed. JC Wang, NR Cozzarelli, pp. 217–42. Cold Spring Harbor, NY: Cold Spring Harbor Lab. Press

10.1038/13333

10.1038/13283

10.1074/jbc.272.26.16206

10.1074/jbc.275.8.5318

10.1074/jbc.273.11.6050

DiGate RJ, 1992, J. Biol. Chem., 267, 20532, 10.1016/S0021-9258(19)36714-6

10.1016/S0969-2126(00)80027-1

10.1046/j.1365-2958.2000.01763.x

10.1038/309677a0

10.1128/jb.173.12.3921-3923.1991

10.1002/j.1460-2075.1985.tb03902.x

10.1002/j.1460-2075.1985.tb03990.x

10.1002/j.1460-2075.1989.tb08466.x

Nadal M, 1994, J. Biol. Chem., 269, 5255, 10.1016/S0021-9258(17)37682-2

10.1046/j.1432-1327.1999.00128.x

10.1093/nar/18.9.2801

10.1126/science.227059

10.1074/jbc.M910091199

10.1016/S0092-8674(00)81566-4

10.1074/jbc.271.13.7602

10.1074/jbc.271.13.7593

10.1006/jmbi.1997.1056

10.1016/S0079-6603(08)60891-0

10.1074/jbc.271.4.1993

Albor A, 1998, Cancer Res., 58, 2091

10.1073/pnas.96.18.10355

10.1021/bi952327w

10.1006/viro.1996.0433

10.1074/jbc.274.53.37795

10.1093/nar/26.7.1841

Shaiu WL, 1999, Pac. Symp. Biocomput.,, 578

10.1038/365227a0

10.1073/pnas.90.24.11508

10.1101/gad.11.3.397

10.1016/S1097-2765(00)80074-X

10.1126/science.279.5356.1504

10.1021/bi992690t

10.1126/science.279.5356.1534

10.1016/S0959-440X(99)80005-0

10.1016/S0969-2126(01)00269-6

10.1093/emboj/16.17.5178

10.1038/37925

10.1126/science.276.5309.126

10.1016/S0092-8674(00)80202-0

10.1093/nar/21.22.5157

10.1016/S0092-8674(85)80027-1

10.1093/nar/12.7.3097

10.1093/nar/13.5.1543

10.1016/0167-4781(85)90057-0

10.1073/pnas.86.9.3080

10.1002/j.1460-2075.1995.tb00224.x

10.1002/j.1460-2075.1990.tb07908.x

10.1016/0092-8674(94)90231-3

10.1021/bi00255a027

10.1093/nar/25.15.3001

10.1074/jbc.M007593200

10.1074/jbc.272.7.3891

10.1021/bi000184u

10.1021/bi992429c

10.1016/S1097-2765(00)80268-3

10.1021/bi980757r

Christiansen K, 1994, J. Biol. Chem., 269, 11367, 10.1016/S0021-9258(19)78134-4

10.1093/nar/25.11.2091

10.1093/nar/26.2.490

10.1021/bi962880t

10.1093/nar/28.14.2658

10.1073/pnas.93.2.785

10.1016/S0969-2126(94)00077-8

10.1016/S0092-8674(00)81411-7

10.1073/pnas.77.4.1847

10.1016/S0092-8674(80)80046-8

10.1016/0092-8674(94)90222-4

10.1073/pnas.75.10.4838

Osheroff N, 1983, J. Biol. Chem., 258, 9536, 10.1016/S0021-9258(17)44700-4

10.1073/pnas.95.14.7876

10.1073/pnas.96.3.881

10.1093/nar/26.18.4205

10.1038/379225a0

10.1093/nar/25.15.3135

10.1006/excr.1999.4587

10.1074/jbc.275.17.13041

10.1074/jbc.M001047200

10.1073/pnas.93.25.14416

10.1093/nar/19.7.1399

10.1038/351624a0

10.1038/42294

10.1074/jbc.275.13.9468

10.1038/7556

10.1073/pnas.93.12.5936

10.1074/jbc.272.18.12132

10.1073/pnas.76.12.6110

10.1073/pnas.76.12.6289

10.1016/S0092-8674(85)80074-X

10.1073/pnas.96.24.13685

10.1073/pnas.93.9.4057

10.1021/bi9912488

10.1021/bi991478m

10.1074/jbc.274.43.30690

10.1074/jbc.274.6.3446

Lindsley JE, 1993, J. Biol. Chem., 268, 8096, 10.1016/S0021-9258(18)53067-2

10.1021/bi00030a018

Maxwell A, 1984, J. Biol. Chem., 259, 14472, 10.1016/S0021-9258(17)42623-8

10.1016/0092-8674(92)90558-T

10.1073/pnas.96.15.8414

Bergerat A, 1994, J. Biol. Chem., 269, 27663, 10.1016/S0021-9258(18)47037-8

10.1073/pnas.92.24.11274

10.1016/S0092-8674(00)81876-0

10.1016/S0092-8674(00)80194-4

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Annual Review of Biochemistry

Tập 70 Số 1

369-413

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