DNA Methylation, Smooth Muscle Cells, and Atherogenesis

Arteriosclerosis, Thrombosis, and Vascular Biology - Tập 23 Số 10 - Trang 1750-1753 - 2003
Mikko Hiltunen1, Seppo Ylä‐Herttuala1
1From the A.I. Virtanen Institute (M.O.H., S.Y.-H.) and Department of Medicine (S.Y.-H.), University of Kuopio, and Gene Therapy Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.

Tóm tắt

DNA methylation is a form of epigenetic modification of the genome that can regulate gene expression. Hypermethylation of CpG islands in the promoter areas leads to decreased gene expression, whereas promoters of actively transcribed genes remain nonmethylated. Because of cellular proliferation and monoclonality of at least some of the lesion cells, atherosclerotic lesions have been compared with benign vascular tumors. 1,2 However, although genetic and epigenetic background favors neoplastic transformation, atherosclerotic plaques never develop to malignant tumors. Among cancer cells, common features are genome-wide hypomethylation, which correlates with transformation and tumor progression. Recent studies have shown that DNA methylation changes occur also during atherogenesis and may contribute to the lesion development.

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Tài liệu tham khảo

10.1073/pnas.70.6.1753

10.1073/pnas.83.20.7951

10.1161/01.ATV.6.2.230

Haust MD. The natural history of human atherosclerotic lesions. In: Moore S ed. Vascular Injury and Atherosclerosis. New York: Dekker; 1981: 1–23.

10.1016/0306-9877(81)90084-0

10.1191/1358863x02vm418oa

10.1016/0021-9150(96)05807-8

10.1038/ng0496-363

10.1016/S0268-960X(96)90009-0

10.1093/hmg/4.suppl_1.1751

10.1007/BF00286709

10.1038/nrg816

10.1038/35000656

10.1126/science.2579435

10.1093/nar/11.19.6883

10.1038/ng0693-110

10.1016/0092-8674(95)90228-7

10.1126/science.1083558

2000, Curr Top Microbiol Immunol, 249, 119

10.1038/sj.onc.1205651

10.1161/atvb.19.9.2171

10.1016/S0008-6363(99)00153-4

10.1093/jn/132.8.2406S

10.1016/S0008-6363(00)00004-3

1993, J Vasc Surg, 18, 170

10.1172/JCI113671

10.1161/circ.88.3.8353880

10.1016/0163-7258(94)00053-6

10.1093/hmg/3.suppl_1.1487

10.1073/pnas.93.19.10366

10.1093/jnci/85.15.1235

10.1016/0092-8674(92)90586-2

10.1006/bbrc.1996.0370

10.1006/bbrc.1996.1151

1972, Nat New Biol, 239, 197

10.1002/j.1460-2075.1992.tb05245.x

10.1136/hrt.80.2.110

10.4049/jimmunol.168.6.2820

1993, J Biol Chem, 268, 17334, 10.1016/S0021-9258(19)85339-5

10.1093/jnci/95.4.327

10.1210/jc.2002-021027

10.1002/ijc.2910600421

10.1006/bbrc.1997.6796

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Arteriosclerosis, Thrombosis, and Vascular Biology

Tập 23 Số 10

1750-1753

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