DIABETIC NEUROPATHY: ABNORMALITIES OF SCHWANN CELL AND PERINEURIAL BASAL LAMINAE. IMPLICATIONS FOR DIABETIC VASCULOPATHY
Tóm tắt
During Wallerian degeneration, the Schwann cell basal laminal ensheathment around myelinated nerve fibres remains after the removal of myelin and axonal debris, forming a corrugated tube within which Schwann cell proliferation takes place. In nerve biopsies from patients with diabetic neuropathy, such residual basal laminal tubes tend to be circular rather than corrugated and appear to be more persistent during regeneration; this suggests increased rigidity and durability. These changes could be the result of increased cross–linkage of type IV collagen or alterations to other components of the basal lamina. A similar mechanism may be responsible for the thickening of perineurial basal laminae and the reduplication of basal laminae around endoneurial capillaries in diabetic patients; such reduplication may lead to reduced compliance of the vessel walls and impaired vascular perfusion.
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Tài liệu tham khảo
BISCHOFF A., 1965, Die diabetische neuropathic, Praxis, 24, 723
CHANG K., 1980, Increased collagen cross–linkages in experimental diabetes. Reversal by βnoproprionitrile and D–penicillamine, Diabetes, 29, 778, 10.2337/diacare.20.10.778
FAGEBERG S.E., 1959, Diabetic neuropathy: a clinical and histological study on the significance of vascular affections, Acta Medica Scandinavica, 164, 1
FOIDART J.M., 1980, Distribution and immunoelectron microscopic localization of laminin, a noncollagenous basement membrane glycoprotein, Laboratory Investigation, 42, 336
JOHNSON P.C., 1981, Human diabetic perineurial cell basement membrane thickening, Laboratory Investigation, 44, 265
JOHNSON P. C., 1984, Dermal nerves in human diabetic subjects, Diabetes, 33, 244, 10.2337/diab.33.3.244
LUBEC G., 1980, Reduced susceptibility of nonenzymatically glucosylated glomerular basement membrane to proteases, Renal Physiology, 3, 4
LUNDBORG G., 1988, Nerve Injury and Repair
PATTERSON P.H., 1985, On the role of proteases, their inhibitors and the extracellular matrix in stimulating neurite outgrowth, Journal of Neurochemistry, 44, S9
PETROL S., 1984, Collagen heterogeneity of thickened basement membranes of human diabetic dermis: tissular immunolabelling of collagen types I, III and IV by light and electron microscopy, Cellular and Molecular Biology, 30, 43
PIHLAJANIEMI T., 1982, Effects of streptozotocin diabetes, glucose, and insulin on the metabolism of type IV collagen and proteoglycan in murine basement membrane–forming EHS tumor tissue, Journal of Biological Chemistry, 257, 14914, 10.1016/S0021-9258(18)33370-2
ROHRBACH D. H., 1982, Alterations in the basement membrane (heparan sulfate) proteoglycan in diabetic mice, Diabetes, 31, 185, 10.2337/diab.31.2.185
SEEDS N. W., 1985, Extracellular proteases and their inhibitors influence neural development, Journal of Neurochemistry, 44, S37
STERNBERG M., 1985, Connective tissue in diabetes mellitus: biochemical alterations of the intercellular matrix with special reference to proteoglycans, collagens and basement membranes, Diabete et Metabolisme (Paris), 11, 27
TARSIO J. F., 1985, Nonenzymatic glycation of fibronectin and alterations in the molecular association of cell matrix and basement membrane components in diabetes mellitus, Diabetes, 34, 477, 10.2337/diab.34.5.477
THOMAS P.K., 1964, Changes in the endoneurial sheaths of peripheral myelinated nerve fibres during Wallerian degeneration, Journal of Anatomy, 98, 175
THOMAS P. K., 1984, Peripheral Neuropathy, 1773