Tác động bảo vệ tế bào của Acetyl-l-Carnitine được chứng minh qua phân tích biểu hiện gen trong não chuột

Molecular Neurobiology - Tập 39 - Trang 101-106 - 2009
Giovanna Traina1, Giuseppe Federighi2, Marcello Brunelli2, Rossana Scuri2
1Department of Internal Medicine, University of Perugia, Perugia, Italy
2Department of Biology, Unit of General Physiology, University of Pisa, Pisa, Italy

Tóm tắt

Acetyl-l-carnitine (ALC), este acetyl của l-carnitine, là một chất tự nhiên tồn tại trong cơ thể. Khi được sử dụng ở nồng độ cao hơn mức sinh lý, ALC có tác dụng bảo vệ thần kinh. ALC đóng vai trò quan trọng trong chuyển hóa trung gian và chuyển hóa ti thể. Nó cũng có tác dụng nuôi dưỡng thần kinh và chống oxy hóa. ALC đã thể hiện hiệu quả và tính dung nạp cao trong điều trị các bệnh lý thần kinh có nguồn gốc khác nhau, và là một phân tử rất được quan tâm cho ứng dụng lâm sàng trong các rối loạn thần kinh khác nhau, chẳng hạn như bệnh Alzheimer và bệnh lý thần kinh đau đớn, mặc dù còn rất ít thông tin về ảnh hưởng của ALC đến biểu hiện gen. Phương pháp hybrid hóa trừ mẫu đã được sử dụng để tạo ra các thư viện DNA bổ sung trừ và xác định các bản sao biểu hiện khác nhau trong não chuột sau khi điều trị ALC kéo dài. Trong bài báo này, chúng tôi cung cấp bằng chứng cho việc tăng cường biểu hiện của synthase prostaglandin D2, transporter photphat vô cơ Na+-phụ thuộc đặc hiệu cho não và cytochrome b oxidase, phức hợp bc1 được kích thích trong não chuột bởi ALC. Ngược lại, việc điều trị ALC đã giảm cường độ biểu hiện của gen ferritin-H. Tất cả những kết quả này gợi ý rằng ALC có thể đóng vai trò bảo vệ tế bào chống lại nhiều tác nhân gây stress trong não.

Từ khóa

#Acetyl-l-carnitine #bảo vệ tế bào #não chuột #biểu hiện gen #stress não.

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