Liệu pháp tế bào giết tế bào do cytokine (CIK) cho bệnh nhân ung thư biểu mô tế bào gan: hiệu quả và an toàn

Experimental Hematology & Oncology - Tập 1 Số 1 - 2012
Yue Ma1, Yingchun Xu1, Lei Tang1, Zan Zhang1, Jian Wang2, Hongxia Wang1
1Department of Oncology, Shanghai Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China
2Department of Surgery, Shanghai Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200127, China

Tóm tắt

Tóm tắt Mục đích

Đánh giá hiệu quả của liệu pháp tế bào giết tế bào do cytokine (CIK) trong điều trị ung thư biểu mô tế bào gan.

Nguyên liệu và phương pháp

Các thử nghiệm ngẫu nhiên pha II và III về liệu pháp dựa trên tế bào CIK đã được xác định thông qua tìm kiếm điện tử với sự kết hợp của các từ khóa "ung thư biểu mô tế bào gan" và "tế bào giết tế bào do cytokine".

Kết quả

Phân tích cho thấy lợi ích sống sót đáng kể (tỉ lệ sống một năm, p < 0.001; tỉ lệ sống hai năm, p < 0.001; tỉ lệ sống trung bình, p < 0.001) ủng hộ cho liệu pháp dựa trên CIK. So sánh nhóm CIK với nhóm không CIK cho thấy thời gian sống không bệnh kéo dài đáng kể (PFS) (p < 0.01). Tỉ lệ kiểm soát bệnh (DCR) và tỉ lệ đáp ứng tổng thể (ORR) cũng được quan sát thấy cao hơn ở những bệnh nhân nhận liệu pháp tế bào CIK (p < 0.01). Trong khi đó, bệnh nhân trong nhóm CIK cho thấy chất lượng cuộc sống (QoL) tốt hơn, giảm nồng độ DNA virus viêm gan B (HBV-DNA) và mức AFP (p < 0.01). So sánh các phân nhóm tế bào T trong máu ngoại vi, phân tích cho thấy tỉ lệ các tế bào T CD3+, CD4+, CD4+CD8+ và CD3+CD4+ tăng đáng kể ở nhóm CIK, so với nhóm không CIK (p < 0.01).

Kết luận

Liệu pháp tế bào CIK cho thấy sự vượt trội đáng kể trong việc kéo dài tỉ lệ sống trung bình, PFS, DCR, ORR và QoL của bệnh nhân ung thư biểu mô tế bào gan. Những kết quả này khuyến khích thực hiện các thử nghiệm ngẫu nhiên kiểm soát quy mô lớn hơn cho các bệnh nhân ung thư biểu mô tế bào gan có hoặc không phối hợp với các phương pháp điều trị khác.

Từ khóa


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